A study on the adsorption characteristics of an amphiphilic phenothiazine drug on activated charcoal in the presence of surfactants

Erdinç, Neşe; Göktürk, Sinem; Tunçay, Melda

doi:10.1016/j.colsurfb.2009.08.031

Cited by 52 publications

(14 citation statements)

References 41 publications

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“…[16][17][18] Tabak et al 13 investigated the characteristics of binding of chlorpromazine and trifluoperazine with SDS by changing the pH. [16][17][18] Tabak et al 13 investigated the characteristics of binding of chlorpromazine and trifluoperazine with SDS by changing the pH.…”

Section: Introductionmentioning

confidence: 99%

An investigation of binding ability of ionic surfactants with trifluoperazine dihydrochloride: insights from surface tension, electronic absorption and fluorescence measurements

Sharma

Mahajan

2012

RSC Adv.

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This work deals with the effect of the ionic surfactants, sodium dodecylsulphate (SDS), dioctylsulphosuccinate sodium salt (AOT), dodecyltrimethylammonium bromide (DTAB) and didodecyldimethylammonium bromide (DDAB), on the physicochemical properties of the antidepressant phenothiazine drug, trifluoperazine dihydrochloride (TFP). Surface tension, fluorescence and electronic absorption measurements have been done in order to study the nature of interactions between drug-ionic surfactant mixtures. Various interfacial, micellar, spectroscopic and corresponding thermodynamic parameters have been calculated from these techniques. The values of the interaction parameter (b) suggest that cationic surfactants exhibit less synergistic interactions with TFP compared to anionic surfactants. To confirm this we further performed fluorescence quenching and electronic absorption titrations of ionic surfactants with TFP. Anionic surfactants (SDS, AOT) have been observed to bind preferentially with TFP over cationic surfactants (DTAB, DDAB), which supports the presence of a cationic charge on the head group of the drug and signifies that anionic surfactants can act as better drug-carriers than cationic surfactants even at very low concentrations. The blue shift and decrease in fluorescence intensity observed in fluorescence quenching methods for TFP + SDS/AOT mixtures confirms the formation of a new complex between interacting species. Also the number of binding sites for drug molecule has been estimated, which helps to give an insight into the mechanism of the drug-surfactant complexes formed. The results indicate that among electrostatic, hydrophobic and van der Waals forces, the former ones are the predominant intermolecular forces between TFP and ionic surfactants.

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Section: Introductionmentioning

confidence: 99%

An investigation of binding ability of ionic surfactants with trifluoperazine dihydrochloride: insights from surface tension, electronic absorption and fluorescence measurements

Sharma

Mahajan

2012

RSC Adv.

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“…The constant of the conductivity cell was calibrated using standard KCl solutions and checked a minimum of three times during the course of the working shift. Specific conductivities of C 12 TAB, C 14 TAB, C 16 TAB, C 16 PC and C 16 PB in the absence and presence of 5.0x10 -6 mol/L EOY were measured at 298 K. The CMC values for each surfactant-EOY system were measured both spectrophotometrically and conductometrically as described previously [27][28][29] . It was found that the values of CMC obtained from two different measurements are in good agreement.…”

Section: Methodsmentioning

confidence: 99%

Spectrophotometric and Conductometric Studies on the Interaction of Anionic Dye Eosin-Y with Cationic Micelles

Erdinç¹,

Göktürk²

2014

Analytical Chemistry Letters

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In this paper, spectrophotometric and conductometric methods were used to study the interaction phenomenon between oppositely charged anionic Eosin-Y and cationic surfactants; dodecyltrimethylammonium bromide, tetradecyltrimethylammonium bromide, cetyltrimethylammonium bromide, cetylpyridinium bromide and cetylpyridinium chloride. Conductivity measurements of surfactants were performed and the degree of micellar ionization was determined in the absence and presence of Eosin-Y. The ionization degree and counterion binding parameter obtained from conductivity data are used to evaluate the interaction mechanism of Eosin-Y in wide range of different hydrophobic cationic microenvironments as well. The absorption spectra were used to quantify the binding constants by means of Benesi-Hildebrand equation. Comparison of the binding degree of Eosin-Y to micelles indicates a direct correlation between binding constant and hydrophobicity. The micellar properties of cationic surfactants at levels below and above their CMCs in aqueous and in the presence of Eosin-Y were also studied using conductivity and spectrophotometry. It was observed that the CMC values of cationic surfactants decreased in the presence of Eosin-Y. The spectrophotometric behavior of Eosin-Y in water-EOH mixture of varying composition was also monitored in order to gain more information about the localization of Eosin-Y in cationic micelles.

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“…These include oxidized cellulose [97], goethite [98], biofilms [99], activated sludge [100], aluminum oxide [101][102][103], organic materials (compost, humic acid, and manure) [104], iron oxides [102,103,105], manganese oxides [105], zero valent iron nano-particles [106], activated charcoal [53] nickel(II) grafted MCM-41 [107], and chitosan particles [108]. Adsorption capacity of these adsorbents is given in Table 6.…”

Section: Miscellaneous Sorbentsmentioning

confidence: 99%

A review on removal of pharmaceuticals from water by adsorption

Akhtar

Amin

Shahzad

2016

Desalination and Water Treatment

254

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A B S T R A C TPharmaceuticals and personal care products are recognized as emerging pollutants in water resources. Various treatment options have been investigated for the removal of pharmaceuticals that include both conventional (e.g., biodegradation, adsorption, activated sludge) and advanced (e.g., membrane, microfiltration, ozonation) processes. This article reviews literature for adsorptive removal of pharmaceuticals from water sources. Adsorbents from various origins were reviewed for their capacity to remove pharmaceuticals from water. These adsorbents include carbonaceous materials, clay minerals, siliceous adsorbents, and polymeric materials. The adsorption capacity of adsorbents to adsorb pharmaceuticals from water is discussed in this study. The review discusses the mechanism for adsorption of pharmaceuticals onto adsorbents as well. Finally, effectiveness of processing parameters during adsorption processes is presented.

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A study on the adsorption characteristics of an amphiphilic phenothiazine drug on activated charcoal in the presence of surfactants

Cited by 52 publications

References 41 publications

An investigation of binding ability of ionic surfactants with trifluoperazine dihydrochloride: insights from surface tension, electronic absorption and fluorescence measurements

An investigation of binding ability of ionic surfactants with trifluoperazine dihydrochloride: insights from surface tension, electronic absorption and fluorescence measurements

Spectrophotometric and Conductometric Studies on the Interaction of Anionic Dye Eosin-Y with Cationic Micelles

A review on removal of pharmaceuticals from water by adsorption

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