A Study on the Clinical and Hormonal Profile of  Polycystic Ovarian Syndrome Patients Attending a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Yadav, Sweta; Vaidya, Achala

doi:10.31729/jnma.5694

Cited by 6 publications

(11 citation statements)

References 9 publications

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“…Lifestyle improvements such as weight loss can improve PCOS symptoms in all patients (adolescents and the elderly) 15 . Reducing BMI is a challenge for patients with PCOS-associated insulin resistance.…”

Section: Resultsmentioning

confidence: 99%

Association Of Acne Vulgaris With Polycystic Ovarian Syndrome In Patients Visiting UOL Teaching Hospital

Malik¹,

Kazmi²

2021

PJMHS

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Background: Polycystic syndrome (PCOS) is the most common endocrine disorder in the world affecting 8% of women. The main characters of PCOS are enlarged ovaries, chronic ovulation, menstrual cycles disturbance, androgen overdose, and insulin resistance leading to acne, hirsutism, and reproductive problems. Acne is a quite common dermatological condition in daily practice. Aim: To determine the association of acne vulgaris with polycystic ovarian syndrome in patients visiting the University of Lahore Teaching Hospital. Study design: Descriptive cross-sectional study. Place and duration of study: Dermatology Outpatient Department, University of Lahore Teaching Hospital Lahore from March 2019 to March 2020. Methodology: It was a descriptive cross-sectional study from March 2019 to March 2020 conducted at the Dermatology Out-patient Department, University of Lahore Teaching Hospital. All patients between the ages of 18 and 40, with acne vulgaris were included in the study. After obtaining informed consent, 101 women with acne vulgaris in I-IV (Indian stages), between the ages of 18-40 years, presented in the Department of Dermatology, University of Lahore Teaching Hospital, from March 2019 to March 2020, were selected for the study. Pregnant females, lactating mothers, and women on hormonal treatment (oral contraceptives or injections) were excluded from the study. A history of acne, oligomenorrhea, hirsutism, seborrhea, alopecia, acanthosis nigricans infertility, obesity and amenorrhea were taken. Weight and height were measured to calculate BMI. Data were collected in a special statistically tool and analyzed using SPSS-25. Results: A total of 101 women were examined having acne vulgaris issue. A total of 101 female were assessed and having history of acne vulgaris. Out of this, 33 were 18–23 years old, while 24 (23.4%) have ages 24–28 years. There were 18 (17.8%) patients who have 29–33 years old. while 38–40 years were 10 (9.9%) years old. Irregular menstrualcycle was reported 34.6% of the study population. As Perth WHO criteria, only 17% of the participants had BMI in normal weight range. The proportion of women, who were overweight and obese were 50.4% and 32.6% in the study population. Conclusion: Acne vulgaris has been identified as a serious skin disease found in all age groups. PCOS is more common among women with acne and obesity is a major risk factor for PCOS.

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Section: Resultsmentioning

confidence: 99%

Association Of Acne Vulgaris With Polycystic Ovarian Syndrome In Patients Visiting UOL Teaching Hospital

Malik¹,

Kazmi²

2021

PJMHS

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“…Prevalence of hirsutism in PCOs generally ranges from 40% to 90% among European and American women. It is common in dark skinned people, and rare in Japanese and Asian females 16 . Another explanation for this discrepancy is the genetically determined differences in skin 5αreductase activator maybe because of diet and environment 16 .…”

Section: Resultsmentioning

confidence: 99%

“…It is common in dark skinned people, and rare in Japanese and Asian females 16 . Another explanation for this discrepancy is the genetically determined differences in skin 5αreductase activator maybe because of diet and environment 16 . Therefore, acne is common in PCOs; in current study, 40% from the PCOs patients had acne.…”

Section: Resultsmentioning

confidence: 99%

Reproductive Hormone Levels and Metabolic Syndrome in Women With Polycystic Ovary Syndrome in Sana'a, Yemen

et al. 2021

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Background and Objectives: Polycystic ovary syndromes (PCOs) are the most complex endocrine disorders of the female reproductive system with metabolic and psychiatric manifestations. It affects 5%-10% of women of childbearing age. There are paucity of information on PCOs. Therefore the present study aimed at the effect of reproductive hormones, metabolic syndromes, smoking and khat chewing on the PCOs among women in Sana'a Subjects and Methods: The study included 45 Yemeni women of the age group 18-45 years with PCOS classified into two groups regarding age: Group I 18-29 years old, Group II 30-45 years old and underwent clinical assessment (waist, BMI and sex hormones, blood pressure, glucose, lipids, and insulin), and transvaginal ultrasound. Clinical data, history of other diseases and data of chewing and smoking also collected.” Also the study included 45 healthy control women matched in age with the cases. Results: The prevalence of MS among PCOs patients was 35% and the most prevalent MS risk factors among PCOs patients were waist circumference (WC) 64.4%, and HDL-C 64.4% respectively, while prevalence of triglycerides (TG), hypertension and fasting blood sugar (FBS) were 28.9%, 20% and 13.3%, respectively. PCOs patients had significant increase in serum levels of luteinizing hormone (LH) (p<0.001), Insulin (p<0.001), HOMA-IR (p<0.001), T testosterone (TT) (p<0.001), DHEA-S (p<0.001) and FBS (p<0.016). Lean PCOs patients had a significant increase in TT than overweight/obese PCOs (p < 0.045) and dehydroepiandrosterone sulfate (DHEA-S) was found to be significantly higher in PCOs women with MS (p<0.011). Insulin resistance was significantly higher in PCOs women with hypertension as compared to PCOs women without hypertension (p<0.023). Conclusion: There is a relationship between PCOS and reproductive hormone disorder. Patients had significant increases in serum levels of LH, LH/Follicle Stimulating Hormone (FSH), Insulin, TT, and DHEA-S. Also, a relationship was found between the syndrome and infertility, hirsutism, irregular menstruation, polycystic ovaries and multiple sclerosis. Peer Review History: Received: 10 July 2021; Revised: 12 August; Accepted: 6 September, Available online: 15 September 2021 Academic Editor: Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com Similar Articles: A RETROSPECTIVE STUDY OF THE TREATMENT RESULTS OF 40 DIVERSE PATIENTS OF ANEMIA

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“…The pathognomonic feature of PCOS that causes irregular menstrual cycles is anovulation. In contrast to biochemical variables, chronic irregular periods (due to anovulation) appear to be a stronger predictor [13][14] . One of the diagnostic criteria for PCOS is oligomenorrhoea 15 .…”

Section: Discussionmentioning

confidence: 99%

Clinical Profile of Patients with Polycystic Ovary Syndrome at Tertiary Care Hospital

Rafiq¹,

Shah²,

Asghar³

2023

PJMHS

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Polycystic ovary syndrome, with an incidence of up to 10%, is one of the communal causes of anovulation in females of reproductive age. Diagnostic criteria for PCOS include enlarged polycystic ovaries, obesity, hirsutism, and oligomenorrhea. These women are more susceptible to endometrial cancer, type II diabetes, dyslipidemia and premature atherosclerosis. Objective: The aim of this study was to determine the different clinical profiles of PCOS patients and to educate patients about the long-term outcomes related with this condition. Methods: This cross-sectional study was conducted at the obstetrics and gynaecology department of Ayub Teaching Hospital, Abbottabad for the duration from 1st January 2019 to 31st December 2019. The study included 110 people with oligomenorrhea, obesity, acne, infertility and hirsutism. Young women who had their menarche less than two years ago, women over 45 years of age, and patients receiving exogenous estrogen or progesterone therapy were excluded from the study. For the social sciences, data was entered and analyzed with SPSS 25.0. The percentages and mean values were determined for several parameters. Results: Of the 110 patients selected for this study, 46 (41.8%) were married and 64 (58.2%) were unmarried. In contrast to rural areas, there were more patients from urban areas (63.6% vs 36.4%). 6.4% of patients were underweight, 20% and 59.1% were overweight and obese. Most patients (71.8%) had oligomenorrhea or amenorrhea. 70% of patients gained weight, many of whom attributed this to menstrual problems. Infertility affected 30% of married patients. Hirsutism and acne were found in 21.8% and 25.5%, respectively. Acanthosis Nigricans, a manifestation of insulin resistance, was found in 31.8% of patients. Eight patients were taking medication for hyperprolactinemia, ten women (10%) had type 2 diabetes taking oral hypoglycemics for glycemic control, and six had hypertension. All patients underwent USG and 85 (77.3%) of them showed a characteristic necklace pattern of follicular arrangement. Conclusion: Using clinical features and ultrasonography in women, PCOS can be accurately diagnosed using the Rotterdam criteria. The two main findings we observed in our patients were weight gain and amenorrhea or oligomenorrhea. It is very important to inform and educate unmarried patients with PCOS about the relationship of this condition with infertility and chronic health problems. Keywords: Oligomenorrhea, PCOS, Anovulation and obesity

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A Study on the Clinical and Hormonal Profile of Polycystic Ovarian Syndrome Patients Attending a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Cited by 6 publications

References 9 publications

Association Of Acne Vulgaris With Polycystic Ovarian Syndrome In Patients Visiting UOL Teaching Hospital

Association Of Acne Vulgaris With Polycystic Ovarian Syndrome In Patients Visiting UOL Teaching Hospital

Reproductive Hormone Levels and Metabolic Syndrome in Women With Polycystic Ovary Syndrome in Sana'a, Yemen

Clinical Profile of Patients with Polycystic Ovary Syndrome at Tertiary Care Hospital

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