A study on the correlation between spleen volume estimated via cavalieri principle on computed tomography images with basic hemogram and biochemical blood parameters

Abstract

Considering its hematological and immunological functions, spleen is a very important organ. A change occurs in its size as the spleen performs these functions. This study aims to examine the possible relationships between spleen volume and the basic hemogram and biochemical parameters in serum. Multidetector computed tomography images and basic hemogram and biochemical parameters of 74 adult individuals, 34 male and 40 female, who were found to be healthy, were used in the study. Spleen volume was estimated using the Cavalieri method on multidetector computed tomography images and the correlations between the volume value with basic hemogram and biochemistry parameters were researched. While negative significant correlations were found between the estimated spleen volume and lymphocyte percentage (r=-0.224) and platelet level (r=-0.271); positive significant correlations were found between hemoglobin level (r=0.228), hematocrit level (r=0.237), alanine aminotransferase (r=0.345), and erythrocyte level (r=0.375). As a result of this study, a relationship was found between spleen volume and lymphocyte percentage, hematocrit level, erythrocyte level, platelet level, and alanine aminotransferase level in serum. We believe that the results of the study will provide a larger perspective to clinicians in the diagnosis of diseases associated with spleen.

Associations of spleen volume with markers of blood count and lipid profile in a large population-based study

“…Similar to our findings, a previous study conducted in small group of healthy individuals also found positive associations of spleen volume with hemoglobin and RBC as well as inverse associations of spleen volume with platelet count and lymphocytes percentage ( 6 ). A comparable result was also obtained from a small group of patients where an inverse association of spleen volume with WBC was observed ( 8 ).…”

“…However, compared to the aforementioned studies, which were conducted on small groups of patients and healthy individuals or using experimental animal models, we used a large sample size of individuals selected from a general population. Although one of the previous studies used CT for spleen volume assessment ( 6 ), we used MRI for spleen volume measurement, which is a more accurate and sensitive marker than CT or ultrasonography ( 16 ).…”

“…Spleen function regulates the abundance of circulating platelets, and it has been shown that splenectomized individuals are prone to thromboembolism ( 5 ). One study reported that a larger spleen volume measured by computed tomography was related with a lower platelet count, while a positive association between spleen volume and hemoglobin levels was found ( 6 ). Similarly, a previous longitudinal study showed that increased splenic metabolic activity after an acute coronary syndrome is associated with pro-inflammatory remodeling of circulating leukocytes and arterial inflammation and is an independent predictor of subsequent cardiovascular events ( 7 ).…”

Comparison of immunophenotypes between Rag2 knockout mice derived from two different sources

“…The spleen is considered a critical immune organ because it helps regulate red blood cells and the immune system [ 14 ]. In this organ, old red blood cells are removed, and the protein portion of hemoglobin is metabolized to maintain the homeostasis of the body [ 15 ]. The spleen consists of two main sections: white pulp (25%) and red pulp (76–79%).…”

Organic and Inorganic Selenium Compounds Affected Lipidomic Profile of Spleen of Lambs Fed with Diets Enriched in Carnosic Acid and Fish Oil

“…The spleen, derived from mesenchymal tissue, is the largest lymphatic organ found in all vertebrates [ 1 ]. The spleen (the multipurpose internal organ) has very important physiological roles in regard to red blood cells, storage of blood, the centre of the blood defence system, the immune system, as well as the formation of lymphocytes and eliminating senescent erythrocyte cells [ 2 , 3 , 4 ]. Moreover, the spleen controls physiologically essential processes, e.g., metabolism of metals, albuminoids, and, what is recently gaining increasing attention, the metabolism of lipids.…”