A study on thyroid, lipid profile and eGFR, protein-creatinine ratio, on assessing risk factor for renal failure

Abstract

Aim: To assess the risk factors for renal dysfunction in a heterogeneous population. To determine the age and sex wise distribution of eGFR and Urinary spot Protein- Creatinine ratio (UPCR) in a heterogeneous population. To estimate the lipid profile and thyroid profile and assess their role as risk factor in renal dysfunction. Introduction: Chronic Kidney Disease (CKD), is a major health problem in India. As per the Kidney Diseases Improving Global Outcomes (KDIGO) 2012, CKD is defined1 as abnormalities of kidney structure or function present for more than three months. Thyroid hormones were also found to influence GFR, tubular secretion and absorption.16,17One study has shown that normal to high levels of Thyroid Stimulating Hormone (TSH) and normal to low levels of free triiodothyronine (FT3) were associated with increased risk of CKD in euthyroid subjects.18 It is also said that high level of serum free thyroxine (FT4) was associated with increased risk of CKD rather than TSH and FT3.There was also associated rapid decline in eGFR.19Many studies have found that hypothyroidism is associated with dyslipidemia and renal dysfunction.