A study to compare the efficacy of platelet-rich plasma and minoxidil therapy for the treatment of androgenetic alopecia

Verma, Kuldeep Chand; Tegta, Geeta Ram; Verma, Ghanshyam; Gupta, Mrinal; Negi, Ashish; Sharma, Reena

doi:10.4103/ijt.ijt_64_18

Cited by 37 publications

(42 citation statements)

References 17 publications

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“…In a very recently published study VermaK. and co-authors also noted that PRP therapy was superior to minoxidil and could be a valuable alternative to topical minoxidil therapy for AGA treatment [15].…”

Section: Discussionmentioning

confidence: 95%

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Pakhomova

Smirnova

2020

IJMS

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Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, and their combination in the treatment of men with AGA and to evaluate the effects of PRP on the proliferation of hair follicle (HF) cells in skin biopsy. Materials and Methods: The study involved 69 men who were divided into 3 groups who received PRP therapy, minoxidil, and their combination. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric of hairs. To assess cell proliferation antibodies to β-catenin, CD34, Ki67, and to Dkk-1 were used. Results. PRP treatment was more effective than minoxidil therapy (p = 0.005). Complex therapy turned out to be more effective than minoxidil monotherapy (p < 0.0001) and PRP monotherapy (p = 0.007). After applying PRP the absolute and relative values of the β-catenin and CD34 expression area increased; an increase in Ki67+ index was also significant. Conclusions: PRP can be considered as a treatment option for AGA. Combined PRP and minoxidil use seems promising for the treatment of AGA. PRP increase in the proliferative activity of HF cells and improves hair morphology in patients with AGA.

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Section: Discussionmentioning

confidence: 95%

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Pakhomova

Smirnova

2020

IJMS

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“…Treatment of AGA remains to be very challenging with only minoxidil and finasteride being the only approved medications by the United States Food and Drug Administration (US‐FDA) and European Medicines Agency (EMA) 7 …”

Section: Discussionmentioning

confidence: 99%

Therapeutic implications of topical cetirizine 1% in treatment of male androgenetic alopecia: A case‐controlled study

Zaky

Khodeir

Ahmed

et al. 2021

J of Cosmetic Dermatology

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Background Androgenetic alopecia (AGA) is the most common form of alopecia in men. Cetirizine, a second‐generation H1 blocker, is known for its anti‐inflammatory properties and its ability to decrease prostaglandin D2 (PGD2) production. Aim To evaluate the efficacy and tolerability of topical cetirizine in male patients with AGA. Methods Two groups of 30 patients each (healthy males aged between 22 and 55 years) with different grades of AGA classified according to the Hamilton‐Norwood classification were recruited for this study. Group A subjects applied 1 mL of 1% topical cetirizine daily, while group B subjects served as controls and were instructed to apply 1 mL of a placebo solution for 6 months. Results Dermoscopic assessment revealed significantly higher hair regrowth among the cetirizine‐treated group (P < .001). The patients’ satisfaction was significantly higher among the cetirizine‐treated group (P < .001). Conclusion The current study highlights a potential role cetirizine might have in treating AGA. It should be noted that studies are lacking in this regard and more randomized and controlled trials are warranted in order to confirm or refute such early findings.

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“…The various studies with their data and limitations are discussed in Table 8 . [ 13 14 15 16 17 18 19 20 21 22 23 ]…”

Section: Discussionmentioning

confidence: 99%

Dermoscopic assessment of microneedling alone versus microneedling with platelet-rich plasma in cases of male pattern alopecia: A split-head comparative study

Aggarwal

Gupta

Jangra³

et al. 2020

Int J Trichol

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Introduction: Male pattern alopecia (MPA) is a common disorder hugely impacting the quality of life of affected individuals. The meager number of options available for treatment has their own limitations. Novel therapies are continuously being researched for. Materials and Methods: The present study included thirty male patients with Hamilton Grade II to Grade V. All patients received four sequential treatments with microneedling (MN) on one half of the scalp and platelet-rich plasma (PRP) with MN (MN + PRP) on the other half for 4 months. Three months following the last session, evaluation was done from the vertex and temporal sites in both the groups by dermoscopic microphotographs by a blinded evaluator. In addition, the patients were asked about their satisfaction score on the basis of treatment outcome. Results: Overall hair thickness showed significant increase in both MN and MN + PRP group. Furthermore, the increase in thickness was almost double in the MN group as compared to MN + PRP group (0.006 and 0.003 mm, respectively). Overall hair density also increased significantly in both the study groups but more in MN + PRP group (14.6 hair/cm 2 ) than the MN group (10.8 hair/cm 2 ). However, the difference between the results of both the groups was not statistically significant. Conclusion: To the best of our knowledge, this is the first split scalp study for MPA. We conclude that MN and PRP are both effective in treatment of androgenetic alopecia and improve the hair parameters and patient satisfaction. However, no additional effect of PRP over MN was observed. Both these therapies are safe and well tolerated without any major side effects. Limitations of our study were small sample size and lack of long-term follow-up.

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A study to compare the efficacy of platelet-rich plasma and minoxidil therapy for the treatment of androgenetic alopecia

Cited by 37 publications

References 17 publications

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

Therapeutic implications of topical cetirizine 1% in treatment of male androgenetic alopecia: A case‐controlled study

Dermoscopic assessment of microneedling alone versus microneedling with platelet-rich plasma in cases of male pattern alopecia: A split-head comparative study

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