A study to compare the therapeutic efficacy of aerobic exercise and paroxetine in fibromyalgia syndrome

Sencan, Sureyya; Ak, Semih; Karan, Ayşe; Müslümanoğlu, Lütfiye; Özcan, Emel; Berker, Ender

doi:10.3233/bmr-2004-17204

Cited by 38 publications

(65 citation statements)

References 21 publications

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“…With each study deleted from the model once, reductions remained statistically significant, ranging from −0.52 to −0.60. With three outliers deleted from the model [14,26,27], results remained statistically significant (, −0.52, 95% CI, −0.67 to −0.36; Q = 66.6, P <0.001; I 2 = 61.0%). Results were similar when data were collapsed so that only one result represented each study (, −0.63, 95% CI, −0.83 to −0.44; Q = 98.2, P <0.001; I 2 = 75.6%).…”

Section: Resultsmentioning

confidence: 99%

Effects of exercise on depression in adults with arthritis: a systematic review with meta-analysis of randomized controlled trials

Kelley¹,

Kelley²,

Hootman³

2015

Arthritis Res Ther

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IntroductionPrevious randomized controlled trials have led to conflicting findings regarding the effects of exercise on depressive symptoms in adults with arthritis and other rheumatic conditions (AORC). The purpose of this study was to use the meta-analytic approach to resolve these discrepancies.MethodsThe inclusion criteria were: (1) randomized controlled trials, (2) exercise (aerobic, strength training, or both) ≥4 weeks, (3) comparative control group, (4) adults with osteoarthritis, rheumatoid arthritis, fibromyalgia or systemic lupus erythematosus, (5) published studies in any language since January 1, 1981 and (6) depressive symptoms assessed. Studies were located by searching 10 electronic databases, cross-referencing, hand searching and expert review. Dual-selection of studies and data abstraction was performed. Hedge’s standardized mean difference effect size (g) was calculated for each result and pooled using random-effects models, an approach that accounts for heterogeneity. Non-overlapping 95% confidence intervals (CI) were considered statistically significant. Heterogeneity based on fixed-effect models was estimated using Q and I2 with alpha values ≤0.10 for Q considered statistically significant.ResultsOf the 500 citations reviewed, 2,449 participants (1,470 exercise, 979 control) nested within 29 studies were included. Length of training, reported as mean ± standard deviation (±SD) was 19 ± 16 weeks, frequency 4 ± 2 times per week and duration 34 ± 17 minutes per session. Overall, statistically significant exercise minus control group reductions were found for depressive symptoms (g = −0.42, 95% CI, −0.58, −0.26, Q = 126.9, P <0.0001, I2 = 73.2%). The number needed-to-treat was 7 (95% CI, 6 to 11) with an estimated 3.1 million (95% CI, 2.0 to 3.7) United States adults not currently meeting physical activity guidelines improving their depressive symptoms if they began and maintained a regular exercise program. Using Cohen’s U3 Index, the percentile reduction was 16.4% (95% CI, 10.4% to 21.9%). All studies were considered to be at high risk of bias with respect to blinding of participants and personnel to group assignment.ConclusionsExercise is associated with reductions in depressive symptoms among selected adults with AORC. A need exists for additional, well-designed and reported studies on this topic.Electronic supplementary materialThe online version of this article (doi:10.1186/s13075-015-0533-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Effects of exercise on depression in adults with arthritis: a systematic review with meta-analysis of randomized controlled trials

Kelley¹,

Kelley²,

Hootman³

2015

Arthritis Res Ther

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“…Die Literatursuche ergab 285 Treffer. Es wurden 2 Studien von der Analyse ausgeschlossen, da die berichteten klinischen Endpunkte nicht die Einschlusskriterien erfüllten [102,112]; 42 Studien [1,4,10,15,19,22,27,28,29,33,36,40,44,45,49,53,55,58,60,66,67,70,72,74,76,77,81,82,84,87,89,90,91,93,95,100,101,105,109,111,112,116] Lebensqualität waren gering (Evidenzbericht, . Tab.…”

Section: El1a Starke Empfehlung Starker Konsensunclassified

Physiotherapie und physikalische Verfahren beim Fibromyalgiesyndrom

Winkelmann

Haüser

Friedel

et al. 2012

Schmerz

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“…EL 2a, open recommendation, consensus.Goldenberg, D. et al 1996 [29]Randomised double blind cross-over study, ( n = 19) AMT 25 mg and Fluoxetine 20 mg. Both drugs are effective in FM and work better in combination.Wolf, F. et al 1994 [30]Double blind placebo controlled trial, n = 42, fluoxetine 20 mg did not improve FM.Nørregaard, J. et al 1995 [82]Double blind control trial, ( n = 22)citalopram 20–40 mg. No benefit reportedSencan, S. et al 2004 [83]Randomised control study, ( n = 60) paroxetine 20 mg vs. aerobic exercise. Both modalities improve pain compared to placebo with no significant difference between the two interventions.Anderberg, U.M.…”

Section: Table A1mentioning

confidence: 99%

Update on Treatment Guideline in Fibromyalgia Syndrome with Focus on Pharmacology

2017

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Fibromyalgia syndrome (FMS) is a chronic condition with unknown aetiology. The pathophysiology of the disease is incompletely understood; despite advances in our knowledge with regards to abnormal central and peripheral pain processing, and hypothalamo–pituitary–adrenal dysfunction, there is no clear specific pathophysiological therapeutic target. The management of this complex condition has thus perplexed the medical community for many years, and several national and international guidelines have aimed to address this complexity. The most recent guidelines from European League Against Rheumatism (EULAR) (2016), Canadian Pain Society (2012), and The Association of the Scientific Medical Societies in Germany (AWMF) (2012) highlight the change in attitudes regarding the overall approach to FMS, but offer varying advice with regards to the use of pharmacological agents. Amitriptyline, Pregabalin and Duloxetine are used most commonly in FMS and though modestly effective, are useful adjunctive treatment to non-pharmaceutical measures.

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A study to compare the therapeutic efficacy of aerobic exercise and paroxetine in fibromyalgia syndrome

Cited by 38 publications

References 21 publications

Effects of exercise on depression in adults with arthritis: a systematic review with meta-analysis of randomized controlled trials

Effects of exercise on depression in adults with arthritis: a systematic review with meta-analysis of randomized controlled trials

Physiotherapie und physikalische Verfahren beim Fibromyalgiesyndrom

Update on Treatment Guideline in Fibromyalgia Syndrome with Focus on Pharmacology

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