A study to evaluate the relationship between periodontitis, cardiovascular disease and serum lipid levels

Sridhar, Raja; Byakod, Girish; Pudakalkatti, Pushpa S; Patil, Rahul

doi:10.1111/j.1601-5037.2008.00318.x

Cited by 24 publications

(24 citation statements)

References 19 publications

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“…HolmPedersen et al [9] investigated the correlations among dental caries, periodontal disease, and cardiac arrhythmia in community-dwelling elderly individuals who were aged 80 or older and showed that there was no association between periodontal disease and arrhythmia. In line with this result, a case-control study by Sridhar et al [10] found that coronary heart disease did not exacerbate the destruction of periodontal tissue. The inconsistencies between these studies might have been due to differences in study design, the adjustments made for confounding variables, and other methodological details.…”

Section: Introductionsupporting

confidence: 67%

The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

Hanindriyo

Yoshihara²,

Hirotomi³

et al. 2013

OJST

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Periodontal disease is recognized as a risk factor for cardiovascular disease (CVD). Some studies have suggested that serum lipids might play a role in the association between periodontal disease and CVD. However, this hypothesis remains unproven. Present study evaluated the association between periodontal disease and CVD-related parameters including electrocardiographic (ECG) parameters and serum lipid levels in the elderly. This study was a prospective cohort study. A total of 107 subjects (57 males and 50 females) from Niigata City's community-dwelling elderly (all aged 75 years old) who possessed at least 20 teeth and did not exhibit ECG abnormalities at the baseline underwent annual examinations for 5 years. Logistic regression analysis was used to assess the relationship between periodontal condition and the presence of ECG abnormalities, after adjusting for confounding factors including serum lipid levels. Logistic regression analysis showed that the subjects who exhibited a poor periodontal condition at the baseline had a 2.97 times greater risk of suffering from ECG abnormalities than the subjects who displayed a good periodontal condition at the baseline (p = 0.019). Furthermore, the subjects who displayed a poor periodontal condition and an unfavorable serum lipid profile at the baseline showed a significantly higher frequency of ECG abnormalities (63.6%) than those who exhibited a healthy periodontal condition and a favorable serum lipid profile (21.6%, p = 0.008) as well as those who displayed a healthy periodontal condition and an unfavorable serum lipid profile (21.4%, p = 0.010). As a conclusion, periodontal condition could be a marker of CVD, even in the healthy elderly.

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Section: Introductionsupporting

confidence: 67%

The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

Hanindriyo

Yoshihara²,

Hirotomi³

et al. 2013

OJST

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“…However, this relationship was not observed between the mild form of periodontal disease as well as the risk of hyperlipidemia in patients with severe chronic periodontitis; risk of hyperlipidemia was 30% higher than those of the normal subjects (19,20). Observations of Sridhar et al indicated that TG levels were not correlated with attachment loss increase in patients with periodontitis (5).…”

Section: Discussionmentioning

confidence: 68%

“…In periodontal disease, cytokines secretion increase is observed, which results in impaired fat metabolism and hyperlipidemia. On the other hand, hyperlipidemia is known as a risk factor for cardiovascular diseases (5,15).…”

Section: Discussionmentioning

confidence: 99%

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Triglyceride and Cholesterol Levels in Patients With Chronic Periodontitis

et al. 2015

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Background: Many studies show that periodontitis is a risk factor for serum lipid levels increase. On the other hand, the increase of serum lipids is clearly a risk factor for cardiovascular diseases. Objectives: The current study aimed to assess the amount of triglycerides and total cholesterol in patients with severe chronic periodontitis. It also evaluated the relationship between the extent of periodontal disease, triglycerides and total cholesterol levels. Patients and Methods:This case-control study included 61 patients with severe chronic periodontitis and 60 healthy subjects aged 20 -50 years. The study samples were selected from individuals who referred to periodontics department of dentistry faculty, zahedan university of medical scoences, Iran, from November 2012 to October 2013. The subjects in both groups were matched in terms of age and gender. The extent of periodontal disease, total cholesterol and triglyceride (TG) levels of the subjects were evaluated. Data were analyzed using Pearson Correlation Coefficient and independent sample T-Test. Results: Triglyceride level in patients with severe chronic periodontitis (121.67 ± 67) and healthy controls (121.78 ± 64) was almost the same and the difference was not statistically significant (P = 0.99). Although total cholesterol level was higher in patients with severe chronic periodontitis (170 ± 40) than the normal subjects (164. 38 ± 30), the difference was not statistically significant (P = 0.41). There was a positive and significant correlation between the extent of periodontal disease and TG level (P = 0.03); while the relationship between the extent of periodontal disease with cholesterol was not statistically significant (P= 0.4). Conclusions: It seems that cohort studies with larger sample sizes on the relationship between periodontitis and cholesterol level (Total, HDL, LDL) are necessary.

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“…These outcomes show that both periodontal tissue breakdown (PD) and level of inflammation (bPP) impinge on the lipid serum level. The results of scientific research on LDL-C concentration in the blood of patients with CVD depending on the state of periodontal tissues are ambiguous [16,17]. However, the majority of reports on patients without cardiovascular burden indicate an impact of periodontitis on lipid disorders expressed by elevated levels of LDL-C, TC and TG, and a reduced level of HDL-C [3,[18][19][20].…”

Section: Discussionmentioning

confidence: 99%

The Association Between Dental Status and Systemic Lipid Profile and Inflammatory Mediators in Patients After Myocardial Infarction

Górski¹,

Nargiełło²,

Opolski³

et al. 2016

Adv Clin Exp Med

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A study to evaluate the relationship between periodontitis, cardiovascular disease and serum lipid levels

Cited by 24 publications

References 19 publications

The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

Triglyceride and Cholesterol Levels in Patients With Chronic Periodontitis

The Association Between Dental Status and Systemic Lipid Profile and Inflammatory Mediators in Patients After Myocardial Infarction

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