A sub-micron CMOS-based ISFET array for biomolecular sensing

Sun, Yuhan; Chen, Guan-Yin; Lin, Chih‐Ting; Huang, Jui Chien; Huang, Yu-Jen; Wen, Chin-Hua

doi:10.1109/nems.2016.7758306

Cited by 1 publication

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Before detection, anti-HbA1c antibodies are coupled with ion field effect transistors [61]. The detection mechanism of the potentiometric HbA1c sensor is that on the gate of the field effect transistor, the biofilm is deposited to form a double electric layer, and its potential changes along with the concentration of HbA1c [62,63].…”

Section: Potentiometric Sensorsmentioning

confidence: 99%

A Review of Electrochemical Sensors for the Detection of Glycated Hemoglobin

Zhan

Zhao

et al. 2022

Biosensors

View full text Add to dashboard Cite

Glycated hemoglobin (HbA1c) is the gold standard for measuring glucose levels in the diagnosis of diabetes due to the excellent stability and reliability of this biomarker. HbA1c is a stable glycated protein formed by the reaction of glucose with hemoglobin (Hb) in red blood cells, which reflects average glucose levels over a period of two to three months without suffering from the disturbance of the outside environment. A number of simple, high-efficiency, and sensitive electrochemical sensors have been developed for the detection of HbA1c. This review aims to highlight current methods and trends in electrochemistry for HbA1c monitoring. The target analytes of electrochemical HbA1c sensors are usually HbA1c or fructosyl valine/fructosyl valine histidine (FV/FVH, the hydrolyzed product of HbA1c). When HbA1c is the target analyte, a sensor works to selectively bind to specific HbA1c regions and then determines the concentration of HbA1c through the quantitative transformation of weak electrical signals such as current, potential, and impedance. When FV/FVH is the target analyte, a sensor is used to indirectly determine HbA1c by detecting FV/FVH when it is hydrolyzed by fructosyl amino acid oxidase (FAO), fructosyl peptide oxidase (FPOX), or a molecularly imprinted catalyst (MIC). Then, a current proportional to the concentration of HbA1c can be produced. In this paper, we review a variety of representative electrochemical HbA1c sensors developed in recent years and elaborate on their operational principles, performance, and promising future clinical applications.

show abstract

Section: Potentiometric Sensorsmentioning

confidence: 99%