A Subpopulation of Mesencephalic Dopamine Neurons Interfaces the Shell of Nucleus Accumbens and the Dorsolateral Striatum in Rats

Dongen, Yvette C. van; Kolomiets, B. P.; Groenewegen, Henk J.; Thierry, Anne‐Marie; Deniau, Jean-Michel

doi:10.1007/978-1-4419-0340-2_10

Cited by 8 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(a) Spiralling projections that ascend from ventral striatal areas to dorsal striatal areas through the VTA and SNc (Nauta et al, 1978;Haber et al, 2000). (b) The NAcc shell projects through the medial SNc directly to the DLS (Van Dongen et al, 2009). (c) The NAcc shell projects to the VTA, which in turn projects to the SNc, which finally projects to the DLS (Ferreira et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, it has also been shown that the NAcc shell may influence DLS function through shorter pathways. Anterograde tracing from the NAcc shell combined with retrograde tracing from the DLS has shown an overlap in labeled neurons in the medial SNc and lateral VTA (Van Dongen et al, 2009). Furthermore, stimulation of neurons in the NAcc shell induced an inhibition of dopaminergic neurons located in the medial SNc and lateral VTA that project to the DLS (Van Dongen et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…In this experiment, dopaminergic neurotransmission was blocked in the NAcc shell in one hemisphere, and in the DLS in the contralateral hemisphere. We hypothesized that, if a serial dopaminergic connection between the NAcc shell and the DLS (Nauta et al, 1978;Haber et al, 2000;Ferreira et al, 2008;Van Dongen et al, 2009) mediates cocaine reinforcement, then unilateral suppression of dopaminergic neurotransmission in the NAcc shell combined with suppression of dopaminergic neurotransmission in the contralateral DLS would result in a response pattern that is similar to a bilateral suppression of dopaminergic neurotransmission in the DLS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The nucleus accumbens shell and the dorsolateral striatum mediate the reinforcing effects of cocaine through a serial connection

Veeneman

Damsteegt

Vanderschuren

2015

Behavioural Pharmacology

View full text Add to dashboard Cite

The reinforcing and addictive properties of cocaine are thought to rely on the dopaminergic innervation of the striatum. The ventromedial [i.e. nucleus accumbens shell (NAcc) shell] and dorsolateral [dorsolateral striatum (DLS)] regions of the striatum are serially connected, and it is thought that slowly developing neuroadaptations are responsible for the recruitment of the DLS in mediating habitual drug use after extended drug experience. Remarkably, we have recently shown that the DLS is also involved in cocaine self-administration after limited use, to modulate the reinforcing properties of the drug, a function usually ascribed to the NAcc shell. Here, we investigated whether the involvement of the DLS in cocaine reinforcement requires dopaminergic activity within the NAcc shell, by performing a pharmacological disconnection study. We infused the dopamine receptor antagonist α-flupenthixol unilaterally into the NAcc shell and infused this same antagonist into the contralateral DLS, thereby disrupting dopaminergic interconnectivity within the striatum. We show that this disconnection results in increased responding for cocaine under a fixed ratio-1 schedule of reinforcement in rats with limited cocaine experience. These data suggest that a functional dopaminergic interaction between the NAcc shell and the DLS mediates cocaine reinforcement during the early stages of drug use.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The nucleus accumbens shell and the dorsolateral striatum mediate the reinforcing effects of cocaine through a serial connection

Veeneman

Damsteegt

Vanderschuren

2015

Behavioural Pharmacology

View full text Add to dashboard Cite

show abstract

“…Clearly, the neural network that becomes engaged during the descent from drug use to full-blown addiction is far more extensive than this. Thus, neuroplastic changes in the nucleus accumbens core contribute to a loss of control over cocaine self-administration (Kasanetz et al, 2010), and these may be conveyed to dorsal striatal substrates of compulsive drug seeking, perhaps through spiraling striato-nigro-striatal loops (Nauta et al, 1978;Haber et al, 2000) or other pathways that indirectly connect the dorsal and ventral striatum (Ferreira et al, 2008;van Dongen et al, 2009). Furthermore, there are several neural mechanisms of compulsive drug seeking and taking that have not been discussed in depth here, but that may contribute to such a network.…”

Section: Discussionmentioning

confidence: 99%

Compulsive drug use and its neural substrates

Lesscher

Vanderschuren²

2012

Reviews in the Neurosciences

View full text Add to dashboard Cite

Drug addiction is a chronic relapsing brain disease, characterized by compulsive drug use. Despite the fact that drug addiction affects millions of people worldwide, treatments for this disorder are limited in number and efficacy. In our opinion, understanding the neural underpinnings of drug addiction would open new avenues for the development of innovative treatments for this disorder. Based on an awareness that drug use and drug reward do not equal drug addiction, there has been increasing interest in developing animal models of addiction that mimick the loss of control over drug use more closely than existing models aimed at studying drug reward. The present review provides an overview of animal studies of compulsive drug use and the neural mechanisms involved. First, the employed models are summarized, with a particular emphasis on models of escalation of drug use and resistance to punishment. Next, we discuss mechanisms within the (ventral and dorsal) striatum and (central) amygdala that have recently been implicated in the compulsive seeking and taking of alcohol and cocaine. The studies discussed here provide a promising line of research that will advance our knowledge of the neural circuits involved in the self-destructive behavior that characterizes drug addiction.

show abstract

“…In parallel, we conducted a series of neurophysiological experiments to study the effects of electrical stimulation of the Acb shell on dopaminergic nigrostriatal neurons projecting to the orofacial, ventrolateral striatum. Preliminary neuroanatomical tracing and neurophysiological results have been published previously (Thierry et al, 2002;van Dongen, Kolomiets, Groenewegen, Thierry, & Deniau, 2009).…”

Section: Significancementioning

confidence: 92%

Mesencephalic dopamine neurons interfacing the shell of nucleus accumbens and the dorsolateral striatum in the rat

Wouterlood

Engel

Daal

et al. 2018

J of Neuroscience Research

Self Cite

View full text Add to dashboard Cite

Parallel corticostriatonigral circuits have been proposed that separately process motor, cognitive, and emotional‐motivational information. Functional integration requires that interactions exist between neurons participating in these circuits. This makes it imperative to study the complex anatomical substrate underlying corticostriatonigral circuits. It has previously been proposed that dopaminergic neurons in the ventral mesencephalon may play a role in this circuit interaction. Therefore, we studied in rats convergence of basal ganglia circuits by depositing an anterograde neuroanatomical tracer into the ventral striatum together with a retrograde fluorescent tracer ipsilaterally in the dorsolateral striatum. In the mesencephalon, using confocal microscopy, we looked for possible appositions of anterogradely labeled fibers and retrogradely labeled neurons, “enhancing” the latter via intracellular injection of Lucifer Yellow. Tyrosine hydroxylase (TH) immunofluorescence served to identify dopaminergic neurons. In neurophysiological experiments, we combined orthodromic stimulation in the medial ventral striatum with recording from ventral mesencephalic neurons characterized by antidromic stimulation from the dorsal striatum. We observed terminal fields of anterogradely labeled fibers that overlap populations of retrogradely labeled nigrostriatal cell bodies in the substantia nigra pars compacta and lateral ventral tegmental area (VTA), with numerous close appositions between boutons of anterogradely labeled fibers and nigrostriatal, TH‐immunopositive neurons. Neurophysiological stimulation in the medial ventral striatum caused inhibition of dopaminergic nigrostriatal neurons projecting to the ventrolateral striatal territory. Responding nigrostriatal neurons were located in the medial substantia nigra and adjacent VTA. Our results strongly suggest a functional link between ventromedial, emotional‐motivational striatum, and the sensorimotor dorsal striatum via dopaminergic nigrostriatal neurons.

show abstract

A Subpopulation of Mesencephalic Dopamine Neurons Interfaces the Shell of Nucleus Accumbens and the Dorsolateral Striatum in Rats

Cited by 8 publications

References 21 publications

The nucleus accumbens shell and the dorsolateral striatum mediate the reinforcing effects of cocaine through a serial connection

The nucleus accumbens shell and the dorsolateral striatum mediate the reinforcing effects of cocaine through a serial connection

Compulsive drug use and its neural substrates

Mesencephalic dopamine neurons interfacing the shell of nucleus accumbens and the dorsolateral striatum in the rat

Contact Info

Product

Resources

About