A subset of enteroendocrine cells is activated by amino acids in the <i>Drosophila</i> midgut

Park, Jeong-Ho; Chen, Ji; Jang, Sungwoo; Ahn, Tae Jung; Kang, Kyung-In; Choi, Min Sung; Kwon, Jae Young

doi:10.1002/1873-3468.12073

Cited by 43 publications

(45 citation statements)

References 37 publications

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“…Alternatively, EEs could be plastic and change their peptide hormone expression profiles with age. Recent studies demonstrate that the mammalian EEs are plastic and can switch their hormone profiles as they differentiate and migrate upward along the crypt-villus axis (Beumer et al, 2018;Park et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

et al. 2019

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Section: Discussionmentioning

confidence: 99%

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

et al. 2019

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“…In larvae, AKH cells of the corpora cardiaca are glucose sensing and autonomously regulate hormone release, which in turn can affect DILP release [594]. Nutrient sensing cells are also present in the intestine and fat body [see [595,596]; summarized in [232]] (Fig. 16) The larval IPC regulation is by the peptides AKH [597], CCHamide2 [327,328], DILP6 [598] and proteins TNF Eiger [599], adiponectin [600] and stunted [601] acting on their receptors (AKHR, CCHa2R, dInR, Grindelwald, AdipoR, and Methusaleh).…”

Section: 1 Control Of Production and Release Of Dilps In Ipcsmentioning

confidence: 99%

“…The IPCs release DILPs that act on different targets to maintain metabolic homeostasis, and in females to ensure that oocytes mature in the ovaries. The brain IPCs are glucose sensing [592,593] and receive modulatory inputs from AKH producing cells [597], other nutrient sensors in fat body [595,604] and probably from the intestine [596] and nutrient sensing brain neurons [350,622,623]. Drosophila females mutated in the dInR are infertile, non-vitellogenic and display impaired JH production [233].…”

Section: 3 Insulin Signaling In Adult Physiology and Reproductionmentioning

confidence: 99%

Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

Nässel

Zandawala

2019

Preprint

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This review focuses on neuropeptides and peptide hormones, the largest and most diverse class of neuroactive substances, known in Drosophila and other animals to play roles in almost all aspects of daily life, as well as in developmental processes. We provide an update on novel neuropeptides and receptors identified in the last decade, and highlight progress in analysis of neuropeptide signaling in Drosophila. Especially exciting is the huge amount of work published on novel functions of neuropeptides and peptide hormones in Drosophila, largely due to the rapid developments of powerful genetic methods, imaging techniques and innovative assays. We critically discuss the roles of peptides in olfaction, taste, foraging, feeding, clock function/sleep, aggression, mating/reproduction, learning and other behaviors, as well as in regulation of development, growth, metabolic and water homeostasis, stress responses, fecundity, and lifespan. We furthermore provide novel information on neuropeptide distribution and organization of peptidergic systems, as well as the phylogenetic relations between Drosophila neuropeptides and those of other phyla, including mammals. As will be shown, neuropeptide signaling is phylogenetically ancient, and not only are the structures of the peptides, precursors and receptors conserved over evolution, but also many functions of neuropeptide signaling in physiology and behavior.

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“…These neurons also express a receptor for the neuropeptide diuretic hormone 31 (DH31) [66]. DH31 is expressed in nutrient-sensing enteroendocrine cells in the gut, which could transmit information about the internal nutritional status to Crz neurons [67]. Thus, any imbalance in internal nutritional and osmotic status could either be sensed directly by Crz neurons or relayed to them via other messengers.…”

Section: How Does Systemic Crz Signaling To the Capa-expressing Va Nementioning

confidence: 99%

A neuroendocrine pathway modulating osmotic stress inDrosophila

Zandawala

Nguyen

Segura

et al. 2019

Preprint

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Environmental factors challenge the physiological homeostasis in animals, thereby evoking stress responses. Various mechanisms have evolved to counter stress at the organism level, including regulation by neuropeptides. Corazonin (Crz) is a neuropeptide known to regulate stress-associated physiology in Drosophila. However, the neural circuits and hormonal pathways underlying this regulation are poorly known. To unveil targets of Crz, we mapped the Crz receptor (CrzR) expression in Drosophila central nervous system (CNS).The CrzR is expressed in peptidergic neurons in the adult CNS, including the median neurosecretory cells and certain clock neurons in the brain, Hugin neurons in the subesophageal zone (SEZ) and CAPA-expressing neurosecretory cells in the SEZ and abdominal neuromeres (Va neurons). We focused on the Va neurons since they produce osmoregulatory peptides (CAPA-1 and CAPA-2), which mediate recovery from desiccation and cold stress. Trans-Tango labeling to determine synaptic partners failed to reveal connections between Crz and Va neurons, suggesting hormonal interactions. To validate the signaling between Crz and Va neurons, we show that knockdown of Crz in Crzproducing neurons and CrzR in Va neurons increases survival under desiccation and delays chill coma recovery. Moreover, immunolabeling data suggests that Crz is released under nutritional and osmotic stress, and in vivo Crz peptide injections influence responses to desiccation and chill coma. Thus, Crz modulates Va neurons to maintain osmotic/ionic homeostasis, which in turn influences stress tolerance. Taken together with previous data, we propose that Crz acts via both the fat body and peptidergic neurons in the CNS to regulate stress-associated physiology.

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A subset of enteroendocrine cells is activated by amino acids in the Drosophila midgut

Cited by 43 publications

References 37 publications

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior

A neuroendocrine pathway modulating osmotic stress inDrosophila

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