A subset of IL-17+ mesenchymal stem cells possesses anti-Candida albicans effect

Yang, Ruili; Liu, Yi; Kelk, Peyman; Qu, Cunye; Akiyama, Kentaro; Chen, Chider; Atsuta, Ikiru; Chen, Wanjun; Zhou, Yanheng; Shi, Songtao

doi:10.1038/cr.2012.179

Cited by 81 publications

(98 citation statements)

References 48 publications

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“…It has been reported that the downstream signaling of IL-17 involves several pathways, including NFκB, MAPK (p38/JNK/ERK) and C/EBP [30]. In addition, Yang et al have found that IL-17 produced by a subset of IL-17 + MSCs could down-regulate the level of TGF-β in MSCs via NFκB pathway [31]. Nevertheless, further studies are warranted to elucidate the molecular mechanism underlying the regulatory effect of IL-17 on the suppressive ability of OE-MSCs.…”

Section: Discussionmentioning

confidence: 99%

IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis

et al. 2016

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Olfactory ecto-mesenchymal stem cells (OE-MSCs) are a population of cells which has been recognized as a new resident stem cell type in the olfactory lamina propria. OE-MSCs have been shown to exert their immunosuppressive capacity by modulating T cell responses, including up-regulation of regulatory T cells (Tregs) and down-regulation of Th1/Th17 cells. As an inflammatory cytokine, IL-17 plays a critical role in orchestrating the inflammatory response during the development of collagen-induced arthritis (CIA). However, it is unclear whether the increased level of IL-17 may affect the immunosuppressive function of OE-MSCs under inflammatory condition. In this study, we found that IL-17 could significantly reduce the suppressive capacity of OE-MSCs on CD4+ T cells and down-regulate the suppressive factors produced by OE-MSCs. Notably, IL-17 treatment abolished the capacity of OE-MSCs in inducing Treg expansion. In addition, knockdown of IL-17R in OE-MSCs significantly enhanced their therapeutic effect in ameliorating CIA upon adoptive transfer. Moreover, IL-17R knockdown-OE-MSCs could efficiently induce Tregs expansion and reduce Th1 and Th17 responses. Taken together, all these data suggest that IL-17R knockdown in OE-MSCs may provide a novel strategy in maintaining their immunosuppressive properties for the treatment of autoimmune diseases.

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Section: Discussionmentioning

confidence: 99%

IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis

et al. 2016

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“…The cells seem to have potent anti-fungal properties. IL-17 positive MSCs inhibited the growth of Candida albicans, in vitro and in vivo in a mouse model [63].…”

Section: Msc and Fungal And Parasitic Infectionsmentioning

confidence: 99%

Mesenchymal stem cells and infectious diseases: Smarter than drugs

Mezey

Nemeth

2015

Immunology Letters

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“…Additionally, recent studies have reported that interleukin 17 (IL-17) family members and their receptors are closely correlated to tumor malignancy and progression [32][33][34] . As a pro-inflammatory cytokine, IL-17B is mainly produced by helper T (Th) 17 cells, innate and adaptive immune cells, and BMSCs [35][36][37][38] , and its receptor (IL-17BR) is present on tumor cells. Activated IL-17B/IL-17BR signaling can increase the tumorigenic and metastatic abilities of tumor cells via stimulating the secretion of chemokines or enhancing inflammatory activities [34,39] .…”

Section: Discussionmentioning

confidence: 99%

Wenshen Zhuanggu formula effectively suppresses breast cancer bone metastases in a mouse Xenograft model

Chen

Wang

et al. 2017

Acta Pharmacol Sin

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Wenshen Zhuanggu formula (WSZG) is a traditional Chinese medicine used as an adjuvant for the prevention of bone metastases in breast cancer patients. In this study we investigated the efficacy of WSZG in preventing bone metastases and the potential mechanisms in a mouse xenograft model of breast cancer bone metastases. This model was established by injection of human MDA-MB-231BO-Luc breast cancer cells alone or a mixture of the cancer cells with bone marrow-derived mesenchymal stem cells (BMSCs) into left ventricle of the heart in female nude mice. Then the mice were treated with WSZG (3.25, 6.5 or 13.0 mg·kg -1 ·d -1, ig) for four weeks, whereas zoledronic acid (100 µg/kg per week, ig) was used as a positive control. The occurrence and development of bone metastases were monitored via bioluminescent imaging, and bone lesions were assessed using micro-CT. Intracardiac injection of the mixture of MDA-MB-231BO-Luc breast cancer cells with BMSCs significantly facilitated the bone metastatic capacity of the breast cancer cells, and aggravated bone lesions in the mouse xenograft model of breast cancer bone metastases. Administration of WSZG dose-dependently inhibited the incidence and intensity of bone metastases and protected against bone lesions by suppressing osteoclast formation and tumor cell infiltration. Furthermore, administration of WSZG caused a marked reduction in the expression of CCL5/CCR5 and IL-17B/IL-17BR in bone metastatic tissues. The results demonstrate that WSZG exerts potential therapeutic effects in a mouse xenograft model of breast cancer bone metastases, which are partially mediated by weakening the interaction between BMSCs and breast cancer cells in the tumor microenvironment.

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A subset of IL-17+ mesenchymal stem cells possesses anti-Candida albicans effect

Cited by 81 publications

References 48 publications

IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis

IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis

Mesenchymal stem cells and infectious diseases: Smarter than drugs

Wenshen Zhuanggu formula effectively suppresses breast cancer bone metastases in a mouse Xenograft model

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