A supramolecular near-infrared nanophotosensitizer from host-guest complex of lactose-capped pillar[5]arene with aza-BODIPY derivative for tumor eradication

Abstract

A supramolecular NIR nanophotosensitizer for dual-modal imaging and ablation of tumors was constructed by loading disulfiram (DSF) into the vesicle from host–guest complex of lactose-capped pillar[5]arene (LacP5) with aza-BODIPY derivative (BSTA).

The design strategy for pillararene based active targeted drug delivery systems

“…10c). 84 The targeted ability of these vesicles was confirmed from the fluorescence images of different cells after incubation with these vesicles (Fig. 10d).…”

“…77 After this, a series of lactose, galactose, and mannose functionalized pillararenes were employed to construct various targeted drug delivery systems. 78–84 All these pillararenes were constructed through the copper( i )-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. These targeted group modified pillararenes were then used in cancer chemotherapy, phototherapy and their synergistic therapy (Fig.…”

A cyclophane-based host–guest charge transfer complex for NIR-II photothermal conversion

“…Organic near-infrared (NIR) photothermal agents (PTAs), which could convert NIR light into heat energy, have attracted considerable attention due to their great potential applications in photothermal therapy (PTT), 1 photoacoustic imaging, 2 seawater desalination 3 and so on. However, the sophisticated design and laborious synthesis process have greatly limited their development, 4 particularly for that in the NIR-II biowindow (1000–1700 nm), 5 which has deeper tissue penetration for phototheranostics 6 and wider spectrum for solar absorption.…”

A mannose-functionalized pillar[5]arene-based supramolecular fluorescent probe for real-time monitoring of gemcitabine delivery to cancer cells

“…In recent years, many glycosylated pillararenes (lactose, galactose, or mannose functionalized pillararenes) with tumour-targeting properties have demonstrated great advantages in the construction of anticancer drugs targeted delivery systems. 12 Multifunctional targeted drug delivery systems based on pillararenes are playing an increasingly significant role in cancer treatment. 13 Meanwhile, pillararene-based fluorescent sensors and probes have been rapidly developed.…”