A surprising effect of paternal alcohol treatment on rat fetuses

Abel, Ernest L.

doi:10.1016/0741-8329(94)00058-l

Cited by 26 publications

(6 citation statements)

References 27 publications

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“…This is reflected in the difficulty of conducting much‐needed large‐scale epidemiological studies, which in turn prevents researchers from conducting systematic reviews and meta‐analyses. Evidence‐based practice involves integrating the best available knowledge by means of a systematic, comprehensive review and synthesis of the research literature 208 ; however, the small number of studies satisfying the criteria for inclusion in systematic reviews, the heterogeneity in terms of the outcomes measured and child ages submitted to meta‐analysis, and the frequent lack of information regarding drinking patterns and timing of drinking necessitate prudence in interpreting the results of meta‐analytic studies 6,55,71–73,209 . For this reason, in agreement with the World Health Organization, 210 a cautionary approach that emphasizes abstinence during pregnancy and the early stages of childhood is recommended, particularly since a safe limit of ethanol intake has not been yet identified.…”

Section: Resultsmentioning

confidence: 99%

Effect of alcohol consumption in prenatal life, childhood, and adolescence on child development

et al. 2011

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The effects of alcohol consumption in adults are well described in the literature, while knowledge about the effects of alcohol consumption in children is more limited and less systematic. The present review shows how alcohol consumption may negatively influence the neurobiological and neurobehavioral development of humans. Three different periods of life have been considered: the prenatal term, childhood, and adolescence. For each period, evidence of the short-term and long-term effects of alcohol consumption, including neurodevelopmental effects and associations with subsequent alcohol abuse or dependence, is presented.

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Section: Resultsmentioning

confidence: 99%

Effect of alcohol consumption in prenatal life, childhood, and adolescence on child development

et al. 2011

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“…There are many studies describing the effects of alcohol on placental function and fetus growth. [5][6][7][8] However, data regarding ECM and growth factors of placenta after alcohol exposure are rather rare. This lack of information stimulated the present study to define the changes in placental extracellular matrix components and growth factors caused by alcohol consumption in rats.…”

Section: Introductionmentioning

confidence: 97%

The effects of alcohol on rat placenta

Akay

Koçkaya

2005

Cell Biochem. Funct.

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In this study, daily food and water consumption and body weights, histopathology of placenta, tenascin (TN), type IV collagen and EGF and its receptor immunolocalization in the placenta of albino rats treated with two doses of alcohol (1 and 5 g kg(-1) day(-1)) were determined. Alcohol was administered in three different periods i.e. the whole 4 weeks before the pregnancy, during the pregnancy, and during the 4 weeks before the pregnancy plus pregnancy itself. The samples of placenta obtained from control and treated rats on days 10, 12, 14, 16, 18, 20 and 21 of gestation were evaluated morphologically and fixed for histology and immunohistochemistry. Some differences in food and water consumption between the groups were determined. The placental weight, especially in the groups receiving 1 and 5 g kg(-1) day(-1) alcohol during the pregnancy, showed increases. The changes in placental histology such as increases in the number and the size of trophoblastic giant cells, cytoplasmic dissolution and nuclear polymorphism, degenerations in spongiotrophoblasts, hyperemia at the basal zone and labyrinth, hyperplasia at the labyrinth and irregular vascularization were seen particularly in the groups receiving alcohol during the pregnancy, and during the 4 weeks before the pregnancy plus pregnancy itself. Increases in the immunolocalization of TN and type IV collagen and decreases in the immunolocalization of EGF and EGFR in the placentas of alcohol-receiving rats were found. In conclusion, ethanol treatment during pregnancy in rats affected placentation and the immunolocalization of TN, type IV collagen, EGF and EGFR in the placentas.

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“…There are many reports of studies of the effects of alcohol on fetus growth and development, [7][8][9][10] but data regarding liver ECM of offspring after alcohol exposure are rather rare. The aim of this study is to evaluate whether dose-dependent effects of alcohol during the gestation period is capable of affecting body weight, liver weight and histology and the immunolocalization of TN and type IV collagen in the liver of fetuses.…”

Section: Introductionmentioning

confidence: 98%

Histological changes in the liver of fetuses of alcohol-treated pregnant rats

Koçkaya

Akay

2006

Cell Biochem. Funct.

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In this study, immunolocalization of tenascin (TN), type IV collagen and histopathological changes in the liver of fetuses of pregnant Wistar albino rats treated with two doses of alcohol (1 and 5 g kg(-1) day(-1)) were determined. The samples of liver obtained from fetuses of rats on day 21 of gestation were evaluated morphologically and fixed for histology and immunohistochemistry. The sections stained with H&E and peroxidase-antiperoxidase (PAP) method for TN and type IV collagen were evaluated and immunohistochemical staining results were examined by the intensity of labelling. Statistical evaluation of data showed that there were no differences in liver weights between the control and calorie control groups; but some differences in relative liver weight between the control and alcohol treatment groups were determined. The changes in the liver histology such as degeneration of the cytoplasm of hepatocytes and increases in the number of megakaryocytes were seen in the fetuses of groups receiving alcohol during pregnancy. Increases in the immunolocalization of TN and type IV collagen in the liver of fetuses of alcohol-receiving rats were also found.

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A surprising effect of paternal alcohol treatment on rat fetuses

Cited by 26 publications

References 27 publications

Effect of alcohol consumption in prenatal life, childhood, and adolescence on child development

Effect of alcohol consumption in prenatal life, childhood, and adolescence on child development

The effects of alcohol on rat placenta

Histological changes in the liver of fetuses of alcohol-treated pregnant rats

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