A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2012

Abstract

Although considerable effort and progress has been made in the search for new anticancer drugs and treatments in the last several decades, cancer remains a major public health problem and one of the major causes of death worldwide. Many sources, including plants, animals, and minerals, are of interest in cancer research because of the possibility of identifying novel molecular therapeutics. Moreover, structure-activity-relationship (SAR) investigations have become a common way to develop naturally derived or semi-synthetic molecular analogues with improved efficacy and decreased toxicity. In 2012, approximately 138 molecules from marine sources, including isolated compounds and their associated analogues, were shown to be promising anticancer drugs. Among these, 62% are novel compounds. In this report, we review the marine compounds identified in 2012 that may serve as novel anticancer drugs.

5-Episinuleptolide Decreases the Expression of the Extracellular Matrix in Early Biofilm Formation of Multi-Drug Resistant Acinetobacter baumannii

“…Marine environments are unlike terrestrial environments, and the abundant biodiversity of marine organisms produce novel and bioactive natural products. In the past decade, more than 3000 newly identified marine-derived compounds have been reported having novel therapeutic uses [ 27 ]. Peach et al found that auromomycin inhibits biofilm formation by Vibrio cholerae with an IC 50 of 60.1 μM [ 39 ].…”

“…Marine natural products have demonstrated pharmaceutical potential, particularly for the development of anticancer [ 27 ], antiviral [ 28 ] and antibacterial drugs [ 29 ]. The soft corals of the Sinularia genus are well known for producing bioactive and structurally versatile natural compounds [ 30 ].…”

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

“…Used empirically in traditional medicine for thousands of years without fully knowing their mechanisms of action, natural products from marine or terrestrial organisms feature a wide variability of chemical structures that modulate a wide range of biological effects (Cerella et al 2014;Morceau et al 2015;Schnekenburger et al 2014Schnekenburger et al , 2015Schumacher et al 2011). These compounds act on a number of therapeutic targets, including processes involved in cancer development and progression (Gaascht et al 2010;Lee et al 2015;Muller et al 2015;Sawadogo et al 2012Sawadogo et al , 2015Teiten et al 2013). Among the vast natural chemical library, we can note isolated plant substances, such as curcumin (Teiten et al 2010(Teiten et al , 2011, aurones (Zwergel et al 2012), plumbagin (Gaascht et al 2014) and fungal secondary metabolites embellicines (Ebrahim et al 2013), which were recently investigated for their chemopreventive and anticancer properties.…”

Synthesis, Characterization and Biological Evaluation of Some Quinoxaline Derivatives: A Promising and Potent New Class of Antitumor and Antimicrobial Agents

“…Compound 11 was furnished via treatment of the 2,3-dichloroquinoxaline derivative 1 with two moles of sodium azide in ethanol as shown in Scheme 3. Compound 11 was found to be in tautomeric equilibrium with the 2,3-diazido derivative 11 1 . Its IR spectrum revealed the absence of the characteristic HNNH 2 group band and its mass spectrum showed a molecular ion peak at m/z 290 (M + ; 7%).…”

“…According to the World Health Organization (WHO), the incidence of this disease is about 6 million cases per year [1][2][3]. Cancer cannot be defined as a single disease, but rather a collection of diseases [4].…”