Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

Gaascht, François; Dicato, Mario; Diederich, Marc

doi:10.1007/s12263-015-0501-3

Cited by 83 publications

(76 citation statements)

References 145 publications

(163 reference statements)

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“…Darker roasts contain a smaller amount of chlorogenic acids [16]. Hydroxyhydroquinone is a compound that is generated from the roasting of coffee beans [28]. Direct measurements of commercially available brewed coffee showed that less than 200 mg chlorogenic acids is generally contained in one serving [37].…”

Section: Test Beveragesmentioning

confidence: 99%

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Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

et al. 2018

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Purpose The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. Methods This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake. Results Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels. Conclusions These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction.

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Section: Test Beveragesmentioning

confidence: 99%

“…Coffee has a complex chemical mixture with hundreds of compounds. Roasting coffee results in the loss of chlorogenic acids and generation of hydroxyhydroquinone [28]. A previous study showed that hydroxyhydroquinone inhibits the chlorogenic acid-induced restoration of endothelial function in a rat model of hypertension [29].…”

Section: Introductionmentioning

confidence: 99%

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

et al. 2018

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“…Natural products originated in marine and terrestrial organisms feature numerous chemical structures that modulate a wide range of biological effects. They have been used in traditional medicine for thousands of years without having a complete understanding of their mechanism of action [30]. Phytochemicals or phytonutrients are bioactive food constituents derived from a plant source; they intervene as inducers of important mechanisms related to antioxidant defense, longevity, cell maintenance, gene expression modulation and DNA repair [31].…”

Section: Chemoprevention In Lung Cancermentioning

confidence: 99%

“…A cup of coffee is a complex mixture containing more than a thousand molecules, heterogeneous bioactive compounds able to act on different cancer hallmarks, helping to prevent its appearance and development [30]. It has been demonstrated that daily drinking of 4-6 cups of regular black coffee, meaning up to 750 mL, is sufficient to prevent carcinogenesis and slow the progression of different types of cancer [33].…”

Section: Chemoprevention In Lung Cancermentioning

confidence: 99%

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Diet in lung cancer: back to natural and healthy food

Ciobanu¹

2017

Lung Breath J

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Lung cancer is a complex and multifactorial disease involving genetic, environmental and lifestyle factors. Amongst the latter, nutritional factors are of critical importance, including diet, alcohol consumption, body weight and physical activity. Because of being the most common cancer worldwide in both men and women, preventive measures should be strongly emphasized. The most important risk factor in lung cancer etiology is cigarette smoking, thus preventing the smoking onset and smoking cessation strategies are crucial. Moreover, there are ten nutritional factors to be addressed, like in any other cancer site prevention: alcoholic beverages, overweight and obesity, physical activity, red and processed meat, salt and salted foods, fruits and vegetables, dietary fibers, dairy products, beta-carotene supplements and breastfeeding. People should be more health-conscious, as lean as possible within the normal range of body weight, daily physically active, limit consumption of energy-dense food, of red meat, especially processed meat, salt, and eat mostly foods of plant origin. Avoiding sugary drinks and limiting alcohol intake is strongly advisable. Cancer survivors should follow recommendations for cancer prevention. As proven already, about one third of lung cancer cases are preventable through a healthy, balanced and diversified diet, maintaining a normal weight and practicing regular physical activity.

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An insight towards anticancer potential of major coffee constituents

et al. 2018

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Cancer is a complex disease that transforms a normal cell into a malignant cell by disturbing different molecular mechanisms. Lately, plant‐derived bioactive products have gained prominent attention to serve as anti‐cancer agents. These natural anti‐neoplastic agents are believed to act as alternatives for the synthetic drugs or could be used to enhance the prospect of other drugs in reducing their dose, thus limiting their possible toxic effects. They could also counterbalance the other anti‐cancer drug‐induced adverse effects. Among natural plant‐derived products, coffee has been reported for its significant anti‐carcinogenic effects in the scientific literature. This article aims to highlight the anti‐cancer potential of different coffee components viz. caffeic acid, chlorogenic acids, caffeine (1,3,7‐trimethylxanthine), cafestol, ferulic acid, and kahweol together in a single article. Based on our article, it is quite clear that these bioactive components have important therapeutic potentials against cancerous cells. However, the lack of clinical data negates their use in humans. Therefore, more research is recommended to achieve the desired pharmaceutical value. We also implore assessing their safety and possible adverse effects prior to their progress into clinical trials. © 2018 BioFactors, 44(4):315–326, 2018

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Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

Cited by 83 publications

References 145 publications

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

Diet in lung cancer: back to natural and healthy food

An insight towards anticancer potential of major coffee constituents

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