A survey of oesophageal cancer: pathology, stage and clinical presentation

Schlansky, Barry; DiMarino, Anthony J.; Loren, David E.; Infantolino, Anthony; Kowalski, Thomas E.; Cohen, Sidney

doi:10.1111/j.1365-2036.2006.02782.x

Cited by 48 publications

(60 citation statements)

References 27 publications

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“…At initial presentation, the two most common symptoms of oesophageal cancer in our region are dysphagia and progressive weight loss, as reported in many other parts of the world [2,3] . Dysphagia usually results from advanced lesions that have led to substantial compromise in the caliber of the oesophageal lumen [3,4] .…”

Section: Discussionsupporting

confidence: 51%

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An uncommon pattern of oesophageal cancer presentation

Oluyemi

Adeyomoye²

2015

CRIM

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Introduction: Common morphological patterns of oesophageal cancer presentation include stricture formation, mucosal ulceration, or the presence of exophytic fungating masses, nodules, and fistulae. The varicoid type is, however, rare. Case presentation:The index case is a 74-year-old lady who had no classical complaints that are often associated with oesophageal cancer and had the varicoid type discovered on endoscopy screening. Conclusion:The purpose of this case report is to document such a pattern for the first time in the authors' environment and to highlight the utility of endoscopy in early detection of malignancy when commonly identified signs and symptoms are absent.

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Section: Discussionsupporting

confidence: 51%

“…Dysphagia usually results from advanced lesions that have led to substantial compromise in the caliber of the oesophageal lumen [3,4] . The oesophagus is not lined by a serosal layer, which allows the smooth muscles of other gastrointestinal components to stretch.…”

Section: Discussionmentioning

confidence: 99%

An uncommon pattern of oesophageal cancer presentation

Oluyemi

Adeyomoye²

2015

CRIM

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“…Unfortunately, in EAC, the majority of tumors have invaded through the esophageal wall at the time of diagnosis. In a cohort of 93 patients, Schlansky and colleagues showed that 79% and 10% of symptomatic new diagnoses of EAC were T3 (tumor invades adventitia) or T4 (invasion of local structures) tumors, respectively [42]. In this setting, cure is rare.…”

Section: The Challenge Of Early Diagnosismentioning

confidence: 99%

“…Unfortunately, the number of tumors detected at this stage is low (<1%) [42]. The challenge we face is how to detect EAC at an earlier stage, which would allow a better chance of survival and potentially more localized and less invasive endoscopic treatment.…”

Section: The Challenge Of Early Diagnosismentioning

confidence: 99%

Strategies to improve outcomes in esophageal adenocarcinoma

Cowie

Noble

Underwood

2014

Expert Review of Anticancer Therapy

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“…Unfortunately the majority of esophageal adenocarcinoma has invaded through the esophageal wall at the time of diagnosis. 7 Surgery remains the main stay of the treatment for resectable diseases but most patients in western countries present with locally advanced disease and 5 year survival rate with surgery alone are dismal at approximately 25%. 8 Outcomes for esophageal adenocarcinoma are poor because 60-70% of patients present with late stage disease, too advanced for treatment with curative intent.…”

Section: Introductionmentioning

confidence: 99%