A survey of the influence of EEDQ on efficient post-functionalization of an Anderson-type polyoxomolybdate towards construction of organic-inorganic hybrids

Fine-tuning non-covalent interactions between hybrid metal-oxo clusters and proteins

“…Furthermore, AE-NH 2 is typically used as a platform for post-functionalisation reactions to form more complex HPOMs. 36 One such example is AE-Biot , which can be synthesised via post-functionalisation of AE-NH 2 with biotin through an amidation reaction. 36 Biotin, also known as vitamin B7, is a biologically active molecule often used in biomedical applications with both hydrophobic and hydrophilic functionalities.…”

Sequential Two-Photon Delayed Fluorescence Anisotropy for Macromolecular Size Determination

“… 31 To extend this range, we tested OADFA on much larger nanoparticle and protein complexes and compared the OADFA-determined sizes with other size-measuring approaches. As rose bengal (Rb) exhibits strong OADF, 20 we synthesized a series of rose bengal-embedded silica nanoparticles (SNPs), 32 , 33 controlling nanoparticle size by adjusting the Rb to tetraethoxysilane ratio ( Figure S1 ). Particle sizes for each batch were determined both by TEM and by OADFA and compared ( Figure 4 ).…”

Solution Dynamics of Hybrid Anderson–Evans Polyoxometalates

“…This series involved the following AE−R HPOMs: an essential vitamin that also has one of the strongest known interactions with its binding proteins. 27,43 Furthermore, AE− Cl, synthesized by prefunctionalization of tris(hydroxymethyl)aminomethane ((HOCH 2 ) 3 CNH 2 ), has both polar and Hbonding functional groups and has been shown to serve as an excellent platform for further postfunctionalization with amines, carboxylic acids, and thiols by nucleophilic substitution or with alkynes by copper-catalyzed azide−alkyne cycloaddition upon replacement of the chlorines with azides. 28,29 In contrast, AE−CH 3 , one of the first reported AE HPOMs, has a similar size and molecular weight to AE−NH 2 but has a nonpolar hydrophobic methyl group instead.…”

“…AE–NH 2 can form H-bonds and can additionally serve as a platform for postfunctionalization by imine or amide bond formation. Such a postfunctionalization yields the aromatic AE–Pyr , functionalized with pyridine (Pyr), and the biologically relevant AE–Biot , functionalized with biotin (Biot), an essential vitamin that also has one of the strongest known interactions with its binding proteins. , Furthermore, AE–Cl , synthesized by prefunctionalization of tris­(hydroxymethyl)­aminomethane ((HOCH 2 ) 3 CNH 2 ), has both polar and H-bonding functional groups and has been shown to serve as an excellent platform for further postfunctionalization with amines, carboxylic acids, and thiols by nucleophilic substitution or with alkynes by copper-catalyzed azide–alkyne cycloaddition upon replacement of the chlorines with azides. , In contrast, AE–CH 3 , one of the first reported AE HPOMs, has a similar size and molecular weight to AE–NH 2 but has a nonpolar hydrophobic methyl group instead . Overall, these HPOMs cover a broad range of possible functional groups and therefore allow for a comprehensive study of the dynamics of HPOMs in solution.…”

“…The AE structure can also be grafted with many different types of organic molecules, which is generally achieved by replacing some of the oxo ligands (formally O 2– ) with tris­(alkoxo) ligands ((OCH 2 ) 3 C–R). Moreover, HPOMs can be further postfunctionalized by many different synthetic pathways , including amidation, nucleophilic substitution, and click chemistry, depending on the nature of the functional group (e.g., R = −NH 2 , −NHCOCH 2 Cl, −NHCOCH 2 N 3 , etc.). Hence, the large diversity and tailorability of AE HPOMs have attracted significant interest in recent years, and among the many reported structures, the bis-functionalized manganese hexamolybdate δ-[MnMo 6 O 18 {(OCH 2 ) 3 C–R} 2 ] 3– (denoted herein as AE–R) has been the most commonly investigated (Figure c). , …”