Assessing the integrity of industrial and civil appliances has become a priority worldwide. Noteworthy, this goal requires a strong synergy between multiple tools, disciplines, and approaches to be attained via a joint hardware-software co-design of the different Structural Health Monitoring (SHM) system components. This work proposes the MAC4PRO architecture, a sensor-tocloud monitoring platform that seamlessly integrates sensing and software technologies for accurate data measurement, transmission, and analysis. The developed solution stands out for its interoperability and versatility, making it a promising candidate for integration in the next generation of smart structures. Our platform was validated during extensive experimental campaigns targeted at various industrial scenarios. The results show that the MAC4PRO architecture can identify subtle changes, such as 1mm size leakage events in pipeline circuits, or less than 1% frequency