2014
DOI: 10.1016/j.jconrel.2014.08.014
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A survey on “Trojan Horse” peptides: Opportunities, issues and controlled entry to “Troy”

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Cited by 114 publications
(119 citation statements)
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“…Some preclinical and clinical developments of CPP conjugates demonstrate their potential as therapeutic agents for drug discovery. There is increasing evidence to suggest that CPPs have the potential to cross several biobarriers (e.g., blood-brain barriers, intestinal mucosa, nasal mucosa, and skin barriers) (Shi et al, 2014). Electroporation has recently been demonstrated as an effective approach for delivering cell-penetrating peptide conjugates of peptide nucleic acids (CPP-PNAs) into a complex cellular system for antisense application.…”
Section: Translocation Of Cpps Into Cellsmentioning
confidence: 99%
“…Some preclinical and clinical developments of CPP conjugates demonstrate their potential as therapeutic agents for drug discovery. There is increasing evidence to suggest that CPPs have the potential to cross several biobarriers (e.g., blood-brain barriers, intestinal mucosa, nasal mucosa, and skin barriers) (Shi et al, 2014). Electroporation has recently been demonstrated as an effective approach for delivering cell-penetrating peptide conjugates of peptide nucleic acids (CPP-PNAs) into a complex cellular system for antisense application.…”
Section: Translocation Of Cpps Into Cellsmentioning
confidence: 99%
“…Another goal of CPP usage in modern medicine is vaccination. Administration of vaccines or pharmaceutical agents in lower concentrations in assistance of (or fused with) CPPs, was noted as a promising opportunity [89]. Although none of the vaccines conjugated with CPPs have passed the FDA threshold into the clinics, there are numerous ongoing preclinical and clinical evaluations of them [90].…”
Section: In Vivo Studies Of Cppsmentioning
confidence: 99%
“…The modern CPP-vaccines were tested for myocardial infarction [92], spinal cord injury [93] and HIV vaccination. Other studies have been re performed in metastatic solid tumors [89] or in acute sensorineural hearing loss caused by cochlear injury [94]. Examples of CPPs conjugated with pharmaceutical agents in clinical development are shown in Table 4 [89].…”
Section: In Vivo Studies Of Cppsmentioning
confidence: 99%
“…Since then, other cell-penetrating peptide (CPP)-containing proteins have been described. In recent years, these peptides have been the focus of intense study aimed at the use of these sequences as tools to deliver a therapeutic cargo (35,36). Unfortunately, endosomal entrapment is often a limitation associated with CPPs, particularly for cationic Tat-like CPPs.…”
Section: Discussionmentioning
confidence: 99%