A Suspected Case of Malignant Hyperthermia After Tooth Extraction: Case Report

Pişkin, Bülent; Ataç, Mustafa Sancar; Konca, Ender; Avsever, Hakan; Sevketbeyoglu, Haldun

doi:10.1016/j.joms.2010.05.097

Cited by 5 publications

(8 citation statements)

References 15 publications

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“…Malignant hyperthermia (MH) is a rare genetic disorder that is characterized by hypermetabolic state of skeletal muscle following exposure to potent volatile or depolarizing muscle relaxants [6]. The earliest findings of malignant hyperthermia are increased ETCO 2 , muscle rigidity, tachycardia and tachypnoea [2].…”

Section: Discussionmentioning

confidence: 99%

“…MH is associated with hereditary disorder. It is an autosomal dominant condition and associated with mutation in a gene known as RYR1, coding for ryanodine receptor 1 [2,6]. The RYR1 gene encodes the key channel that mediates the calcium release in skeletal muscle during excitation-contraction coupling.…”

Section: Introductionmentioning

confidence: 99%

“…It reduces extracellular calcium by inhibiting calcium release from the sarcoplasmic reticulum [6]. Medical history revealed that he had allergic rhinitis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Malignant hyperthermia in a cleft lip and palate patient: A case report

Ramasamy

Lee

Nabil

et al. 2015

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Malignant hyperthermia in a cleft lip and palate patient: A case report

Ramasamy

Lee

Nabil

et al. 2015

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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“…During surgery, there are numerous factors that may induce fatal hyperthermia (6–9), including pyemia, thyroid storm, pheochromocytoma and MH. MH (25) refers to the anesthetic-induced abnormally high metabolic status of skeletal muscle and this causes rhabdomyolysis.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the effects of hyperthermia on the lung and its mechanism of action remain unclear at present. In the clinic, cases of fatal hyperthermia caused by various intraoperative factors are frequently reported (6–9), and a comprehensive treatment measure is the key to successful treatment.…”

Section: Introductionmentioning

confidence: 99%

Effects of ulinastatin administered at different time points on the pathological morphologies of the lung tissues of rats with hyperthermia

Qin

Tian

et al. 2014

Experimental and Therapeutic Medicine

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Hyperthermia not only directly induces cell injury of body tissues, but also causes the body to release large amounts of inflammatory mediators and cells with extensive biological activities to induce a systemic inflammatory response and immune dysfunction. Thus, hyperthermia causes systemic inflammatory response syndrome, aggravating injuries to various organs. This study aimed to observe the effects of ulinastatin (UTI) administered at different time points on the cellular morphologies of the lung tissues of rats with systemic hyperthermia. A total of 40 male Sprague Dawley rats were randomly divided into five groups: The normal control group (C group), the hyperthermia group without medication (H group), the hyperthermia and UTI pre-treatment group (HU group), the group treated with UTI at 1 h after hyperthermia (HU1 group), and the group treated with UTI at 2 h after hyperthermia (HU2 group). The systemic hyperthermia rat model was established in a heating chamber with a biological oxygen supply. For the HU, HU1 and HU2 groups, UTI (5×104 U/kg) was administered at different time points. For the C and H groups, an equivalent volume of normal saline was administered. During heating, the respiratory frequency and rectal temperature were measured and recorded once every 30 min. After 2.5 h of heating, the wet/dry weight (W/D) ratio of the lung tissues of the rats was measured. Additionally, the cellular morphologies of the lung tissues were observed under light and electron microscopes. The respiratory frequencies and lung tissue W/D ratios of the rats in the various hyperthermia groups were significantly higher than those of the rats in the C group (all P<0.05). The respiratory frequencies and lung tissue W/D values of the HU and HU1 groups were significantly lower than those of the H group (all P<0.05). Under the light microscope, the bronchial surrounding tissues of the HU and HU1 groups were loose, and the majority of the pulmonary alveolar structures were normal; the H and HU2 groups presented a number of changes, including pulmonary interstitial hyperemia, alveolar epithelial swelling and emphysema. Under the electron microscope, it was observed in the type II epithelial cells of the pulmonary alveoli of the H group that the mitochondria were swollen, the cell ridges were shortened, the microvilli were thin and increased, and the alveolar wall was thickened. Also, an increased number of infiltrating neutrophils were visible. In addition, the type II epithelial cells of the HU2 group also presented these changes to different extents and the changes in the HU and HU1 groups were the mildest. These results indicate that the early application of UTI relieves edema and the extent of cell injury of the lung tissue in rats with systemic hyperthermia.

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Delayed Onset of Malignant Hyperthermia in the Intensive Care Unit

Twine¹

2013

Critical Care Nursing Quarterly

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Malignant hyperthermia (MH) has been described as a rare inherited autosomal dominant metabolic syndrome triggered in patients after exposure to certain inhalation anesthetics and depolarizing muscle relaxants. Typically MH is seen within the operating room and postanesthesia care environment. This case study will discuss a patient with an atypical MH crisis in the intensive care unit. Pathophysiology, genetic basis of and testing for MH-susceptibility as well as the role of the critical care nurse in the management of this potentially fatal disorder will be discussed.

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A Suspected Case of Malignant Hyperthermia After Tooth Extraction: Case Report

Cited by 5 publications

References 15 publications

Malignant hyperthermia in a cleft lip and palate patient: A case report

Malignant hyperthermia in a cleft lip and palate patient: A case report

Effects of ulinastatin administered at different time points on the pathological morphologies of the lung tissues of rats with hyperthermia

Delayed Onset of Malignant Hyperthermia in the Intensive Care Unit

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