A symmetrical luminol based azo derivative for trimodal ratiometric Hg2+ sensing and its application to bioimaging in living cells

Development of a near infrared novel bioimaging agent via co-oligomerization of Congo red with aniline and o-phenylenediamine: experimental and theoretical studies

“… 26 Azo dyes have specific physico-chemical and biological properties which are widely utilized in cellullar staining to visualize cellular components and metabolic processes. 27–30 With the aim to study the influence of the multifunctional dye moiety on the structural properties of conventional conjugated polymers, the present work reports the chemical oxidative co-oligomerization of Congo red with aniline and o -phenylenediamine. The main aim of this investigation was to prepare a water soluble non-cytotoxic NIR emitting polymer which could be utilized as a bioimaging agent.…”

Mitochondria-targeted BODIPY dyes for small molecule recognition, bio-imaging and photodynamic therapy

“…When Hg 2+ ions accumulate to a certain level in the human body, it can seriously affect the function of kidneys, heart, brain, immune system, lungs, central nervous system and other tissues, and can even cause death. 154 Therefore, real-time accurate detection of Hg 2+ in living organisms is valuable for human health. In 2016, Das et al designed and synthesized a mitochondrial Hg 2+ NIR fluorescent probe 51 based on the intramolecular charge transfer (ICT) mechanism, using the dimethylpyridyl unit as the recognition group for Hg 2+ and N cations as the mitochondrial localization group (Fig.…”

Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives

“…A large number of chemosensors have been reported and investigated so far, recently, a versatile biphenyl-azo conjugated aldoxime ( 10a ) was found to be a selective probe for the detection of Hg 2+ and F − over a wide range of metal analytes in intracellular living system [ 74 ]. Another selective probe for the detection of Hg 2+ in the living cells, a C 2 symmetric azo derivative of luminol (Azolum) ( 10b ) that has the non-destructive cellular permeability and could quench the fluorescence only in the presence of Hg 2+ ions [ 75 ]. In a separate experiment, a selective and sensitive biomarker rhenium(I) carbonyl complex bearing azo-phenol ligand ( 10c ) for cancer cell bio-imaging was synthesized, the cytotoxicity of this complex was determined and found to be moderately toxic for the cells [ 76 ] ( Figure 10 ).…”