A Synthesis of Thalidomide

Chang, Meng‐Yang; Chang, Chung-Ho; Chen, Shui‐Tein; Chang, Nein-Chen

doi:10.1002/jccs.200200060

Cited by 12 publications

(1 citation statement)

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“…In fact, discovery of lenalidomide and pomalidomide had led scientists to explore the modification of thalidomide ( Figure 1) to improve its efficacy and decrease its teratogenic and neurotoxic effects. Although there are several synthetic methods for making thalidomide many of the reported syntheses are often multistep processes which use exotic or expensive reagents, maintain long reaction times, and produce very low yields [32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

A Novel Green Synthesis of Thalidomide and Analogs

Benjamin

2017

Journal of Chemistry

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Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.

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