A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats

Solbrig, Marylou V.; Fan, Yijun; Hermanowicz, Neal; Morgese, Maria Grazia; Giuffrida, Andrea

doi:10.1016/j.expneurol.2010.09.003

Cited by 31 publications

(23 citation statements)

References 89 publications

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“…These effects are mediated by the CB 1 R/CB 2 R-mediated activation of the ERK 120 and PI3K-Akt signaling pathways 119,126 in vitro . These data were corroborated by studies showing that CB 1 R/CB 2 R activation also promotes oligodendrogenesis in the subventricular zone of the postnatal rodent brain in vivo 118 , particularly upon hypoxic-ischemic damage in neonatal 127 and adult animals, and viral encephalitis-induced disease 128 . Although the above observations seem compelling, some investigators have been unable to reproduce these findings, at least when attempting to differentiate mouse neural progenitors to generate astroglia or oligodendroglia in vitro 129,130 .…”

Section: Endocannabinoids and Neuronal Developmentmentioning

confidence: 53%

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

Maccarrone¹,

et al. 2014

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Of the many signaling lipids, endocannabinoids are being increasingly recognized as having an important involvement in neuronal and glial development. Recent experimental evidence suggests that during neuronal differentiation, endocannabinoid signaling undergoes dynamic reorganization that results in a fundamental role-switch from the prenatal determination of cell fate to the homeostatic regulation of synaptic neurotransmission and bioenergetics in the mature nervous system. These studies also offer novel insights into neuropsychiatric disease mechanisms, and contribute to the public debate about the benefits and risks of cannabis use during pregnancy and in adolescence.

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Section: Endocannabinoids and Neuronal Developmentmentioning

confidence: 53%

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

Maccarrone¹,

et al. 2014

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“…Cannabinoid signaling has also been suggested to participate in postnatal myelination processes [131–133]. Postnatal myelination involves radial migration of astrocyte-like (type B) precursor cells from the SVZ to the overlying white matter, where these cells are differentiated into astrocytes and oligodendrocytes (reviewed in [134,135]).…”

Section: Involvement Of Endocannabinoid Signaling In Neural Developmentmentioning

confidence: 99%

“…Agonist stimulation of CB 1 R and CB 2 R increases the expression of myelin basic protein in subcortical white matter [132]. Furthermore, cannabinoid signaling has been suggested to participate in adult oligodendrogenesis after toxic or autoimmune demyelinating lesions, when precursor cells are recruited from the SVZ towards the injured area and give rise to oligodendrocytes [14,131,133]. …”

Section: Involvement Of Endocannabinoid Signaling In Neural Developmentmentioning

confidence: 99%

Lasting Impacts of Prenatal Cannabis Exposure and the Role of Endogenous Cannabinoids In the Developing Brain

2011

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Cannabis is the most commonly used illicit substance among pregnant women. Human epidemiological and animal studies have found that prenatal cannabis exposure influences brain development and can have long-lasting impacts on cognitive functions. Exploration of the therapeutic potential of cannabis-based medicines and synthetic cannabinoid compounds has given us much insight into the physiological roles of endogenous ligands (endocannabinoids) and their receptors. In this article, we examine human longitudinal cohort studies that document the long-term influence of prenatal exposure to cannabis, followed by an overview of the molecular composition of the endocannabinoid system and the temporal and spatial changes in their expression during brain development. How endocannabinoid signaling modulates fundamental developmental processes such as cell proliferation, neurogenesis, migration and axonal pathfinding are also summarized.

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“…The GFAP + region was used to delineate the penumbra surrounding the core of the infarct (Supplementary Figure 1) [18] . The number of cells in the penumbra and subventricular zone (SVZ) that were positive for various markers was quantified using digitized confocal images, captured from a minimum of five serial coronal sections spaced 250 μm apart, corresponding to the Bregma coordinates -0.8 mm through 2.5 mm [19] . The data are presented as the total number of positive cells within the specific region analyzed.…”

Section: Immunohistochemistry Stainingmentioning

confidence: 99%

WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats

Sun

Fang

et al. 2012

Acta Pharmacol Sin

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Aim: To explore whether the synthetic cannabinoid receptor agonist WIN55,212-2 could protect oligodendrocyte precursor cells (OPCs) in stroke penumbra, thereby providing neuroprotection following permanent focal cerebral ischemia in rats. Methods: Adult male SD rats were subjected to permanent middle cerebral artery occlusion (p-MCAO). The animals were administered WIN55,212-2 at 2 h, and sacrificed at 24 h after the ischemic insult. The infarct volumes and brain swelling were assessed. The expression of cannabinoid receptor type 1 (CB1) in the stroke penumbra was examined using Western blot assay. The pathological changes and proliferation of neural glial antigen 2-positive OPCs (NG2 + cells) in the stroke penumbra were studied using immunohistochemistry staining. Results: p-MCAO significantly increased the expression of CB1 within the stroke penumbra with the highest level appearing at 2 h following the ischemic insult. Administration of WIN55,212-2 (9 mg/kg, iv) significantly attenuated the brain swelling, and reduced the infarct volume as well as the number of tau-immunoreactive NG2 + cells (tau-1 + /NG2 + cells) in the stroke penumbra. Moreover, WIN55,212-2 significantly promoted the proliferation of NG2 + cells in the stroke penumbra and in the ipsilateral subventricular zone at 24 h following the ischemic insult. Administration of the selective CB1 antagonist rimonabant (1 mg/kg, iv) partially blocked the effects caused by WIN55,212-2. Conclusion: Tau-1 is expressed in NG2 + cells following permanent focal cerebral ischemic injury. Treatment with WIN55,212-2 reduces the number of tau-1 + /NG2 + cells and promotes NG2 + cell proliferation in the stroke penumbra, which are mediated partially via CB1 and may contribute to its neuroprotective effects.

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A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats

Cited by 31 publications

References 89 publications

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

Lasting Impacts of Prenatal Cannabis Exposure and the Role of Endogenous Cannabinoids In the Developing Brain

WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats

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