A system for the quantitative determination of hydrocarbons in human breath

Seabra, Laís Santos; Braganza, Joan M.; Jones, Martin

doi:10.1016/0731-7085(91)80208-q

Cited by 16 publications

(4 citation statements)

References 7 publications

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“…The direct sampling of airway cells and mediators can be achieved by invasive techniques, such as bronchoscopy with lavage and biopsy, or by the analysis of induced sputum. However, exhaled breath contains volatile mediators, such as NO (7), carbon monoxide (CO) (8)(9)(10), ethane and pentane (11)(12)(13), and nonvolatile substances in the liquid phase of exhalate, termed breath condensate (e.g., hydrogen peroxide) (14)(15)(16)(17). The noninvasive measurement of exhaled mediators makes them ideally suited for the serial monitoring of patients.…”

Section: Assessment Of Airway Inflammationmentioning

confidence: 99%

ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005

2005

Am J Respir Crit Care Med

2,817

979

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Section: Assessment Of Airway Inflammationmentioning

confidence: 99%

ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005

2005

Am J Respir Crit Care Med

2,817

979

View full text Add to dashboard Cite

“…The direct sampling of airway cells and mediators can be achieved by invasive techniques such as bronchoscopy with lavage and biopsy, or by the analysis of induced sputum. However, exhaled breath contains volatile mediators such as NO (2), CO (3)(4)(5), ethane, and pentane (6)(7)(8), but also nonvolatile substances in the liquid phase of exhalate, termed breath condensate, for example, hydrogen peroxide (9)(10)(11)(12). The noninvasive nature of the measurement of exhaled mediators makes them ideally suited for the serial monitoring of patients.…”

Section: Recommendations For Standardized Procedures For the Online Amentioning

confidence: 99%

Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children—1999

1999

Am J Respir Crit Care Med

739

127

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“…However, descriptions of these techniques often provide limited methodological detail and limited documentation of method validation and performance; various investigators have noted this fact [17][18][19][20]. As a result, most investigators have had to develop their own techniques.…”

Section: Introductionmentioning

confidence: 99%

Methods for Measuring Ethane and Pentane in Expired Air From Rats and Humans

KNUTSON¹,

HANDELMAN²

2001

Bio-Assays for Oxidative Stress Status

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Numerous studies in animals and humans provide evidence that ethane and pentane in expired air are useful markers of in vivo lipid peroxidation. The measurement of breath hydrocarbons, being noninvasive, is well suited for routine use in research and clinical settings. However, the lack of standardized methods for collecting, processing, and analyzing expired air has resulted in the use of a wide variety of different methods that have yielded highly disparate results among investigators. This review outlines the methods that we have developed and validated for measuring ethane and pentane in expired air from rats and humans. We describe the advantages of these methods, their performance, as well as potential errors that can be introduced during sample collection, concentration, and analysis. A main source of error involves contamination with ambient-air ethane and pentane, the concentrations of which are usually much greater and more variable than those in expired air. Thus, it appears that the effective removal of ambient-air hydrocarbons from the subject's lungs before collection is an important step in standardizing the collection procedure. Also discussed is whether ethane or pentane is a better marker of in vivo lipid peroxidation.

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A system for the quantitative determination of hydrocarbons in human breath

Cited by 16 publications

References 7 publications

ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005

ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005

Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide in Adults and Children—1999

Methods for Measuring Ethane and Pentane in Expired Air From Rats and Humans

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