A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment

Janbek, Janet; Sarki, Mahesh; Specht, Ina Olmer; Heitmann, Berit Lilienthal

doi:10.1038/s41430-019-0400-6

Cited by 57 publications

(48 citation statements)

References 52 publications

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“…However, it is not entirely clear that maternal iron supplementation during pregnancy can reverse effects of maternal ID during pregnancy on neurodevelopment [77,78]. Two recent systematic reviews found no evidence that iron supplementation during pregnancy improved neurodevelopment in offspring [76,79]. The specific frequency of ID in the populations studied may have contributed to the absence of a statistically significant effect: benefits may have been confined to patients who were iron deficient or had marginal iron stores at the time of treatment [79,80].…”

Section: Impact Of Id During Pregnancymentioning

confidence: 99%

“…ID can contribute to impaired cognitive development in early childhood [76], and the opportunity to intervene during pregnancy and avoid this complication is appealing from a public health perspective. However, it is not entirely clear that maternal iron supplementation during pregnancy can reverse effects of maternal ID during pregnancy on neurodevelopment [77,78].…”

Section: Impact Of Id During Pregnancymentioning

confidence: 99%

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Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters

2020

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A normal pregnancy consumes 500-800 mg of iron from the mother. Premenopausal women have a high incidence of marginal iron stores or iron deficiency (ID), with or without anemia, particularly in the less developed world. Although pregnancy is associated with a "physiologic" anemia largely related to maternal volume expansion; it is paradoxically associated with an increase in erythrocyte production and erythrocyte mass/kg. ID is a limiting factor for this erythrocyte mass expansion and can contribute to adverse pregnancy outcomes. This review summarizes erythrocyte and iron balance observed in pregnancy; its implications and impact on mother and child; and provides an overview of approaches to the recognition of ID in pregnancy and its management, including clinically relevant questions for further investigation.

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Section: Impact Of Id During Pregnancymentioning

confidence: 99%

Section: Impact Of Id During Pregnancymentioning

confidence: 99%

Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters

2020

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“…3,4 ID impairs the health and well-being of women and increases the risk of adverse maternal and neonatal outcomes. 5,6 Our research group has observed elevated bone remodeling in IDA young adult women that improved during iron recovery, suggesting that chronic ID may be a risk factor for future osteoporosis in women. [7][8][9] According to the Global Burden of Disease Study 2016, IDA is the first cause of years lived with disability burden in women.…”

Section: Introductionmentioning

confidence: 97%

Iron Deficiency in Menstruating Adult Women: Much More than Anemia

Fernández-Jiménez

Moreno

Wright

et al. 2020

Women's Health Reports

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Background: Iron deficiency anemia (IDA) is highly prevalent in women of child-bearing age. However, their nonhematological symptoms have been overlooked. This study aims to analyze the nonhematological features and symptoms of IDA in a group of women of reproductive age and the changes occurred during iron therapy. Materials and Methods: IDA women underwent dietary, physical activity, menstrual blood loss, and cognitive function assessment at baseline. Hematological and biochemical parameters were analyzed. Executive attention was tested by the flanker task and working memory by the 2-back task. Oral iron therapy (ferrous sulfate) was given to 35 women for 8 weeks and the changes in iron status, biochemical markers, cognitive function, and nonhematological symptoms were evaluated. Results: Patients presented nonhematological symptoms: pica, 32.4%; cheilitis, 20.6%; restless legs syndrome (RLS), 20.6%; diffuse hair loss, 55.9%; and ungual alterations, 38.2%. Two or more symptoms were present in 58.8% of women. Serum iron and working memory were correlated at baseline. Multivariate analyses show associations (odds ratio [OR], 95% confidence interval [CI]) between pica and reaction time in the working memory test (OR 2.14, 95% CI 1.19-3.87, p = 0.012); RLS with total serum protein (OR 0.08, 95% CI 0.06-0.92, p = 0.043); and cheilitis with mean corpuscular hemoglobin (OR 0.388, 95% CI 0.189-0.799, p = 0.01). Pica, cheilitis, and RLS completely resolved with iron therapy, and ungual alterations and hair loss improved in 92.3% and 84.2% of women, respectively. Better performance in executive attention and working memory was observed after iron therapy. Conclusions: More attention should be given to the nonhematological manifestations of IDA to improve the quality of life of menstruating women.

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“…Maternal and postpartum iron deficiency anemia (IDA) can lead to low birth weight, preterm birth, perinatal and neonatal mortality [1], lactation problems [2], postpartum depression [3,4], and early-childhood iron deficiency (ID) [5][6][7]. Preventive oral iron supplementation reduces the incidence of maternal ID or anemia by 57-70% [8] but is insufficient for severe IDA [9].…”

Section: Introductionmentioning

confidence: 99%

Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy

Wesström

2020

Arch Gynecol Obstet

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Purpose To evaluate the efficacy and safety for mother and child of using intravenous iron isomaltoside (IV-IIM) during pregnancy. Methods Using an appointment register, we retrospectively identified all pregnant women who received a single dose of 1000 or 1500 mg IV-IIM in the maternity ward of Falu Hospital and subsequently gave birth between August 6, 2013 and July 31, 2018. Women who received IV-IIM (case group) were individually matched with pregnant women who did not receive IV-IIM (control group) by delivery date, maternal age (± 2 years), and parity. Adverse drug reactions (ADRs), demographic characteristics, hemoglobin and s-ferritin counts, pregnancy and delivery complications, and infant data (APGAR score, pH at umbilical artery, birthweight, birth length, intrauterine growth restriction and neonatal ward admission). Data were obtained from electronic patient charts. SPSS was used for descriptive statistics. Results During the 5-year period, 213 women each received a single administration of IV-IIM. Ten (4.7%) ADRs occurred during IV-IIM administration. All ADRs were mild hypersensitivity reactions, abated spontaneously within a few minutes, and did not recur on rechallenge. No association between IIM dose and ADR frequency was noted. Maternal and fetal outcomes, including hemoglobin counts at delivery and postpartum, were similar in the case and control groups. Conclusion These results support the convenience, safety, and efficacy of a single high-dose (up to 1500 mg) infusion of IV-IIM for iron deficiency or iron deficiency anemia during pregnancy.

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A systematic literature review of the relation between iron status/anemia in pregnancy and offspring neurodevelopment

Cited by 57 publications

References 52 publications

Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters

Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters

Iron Deficiency in Menstruating Adult Women: Much More than Anemia

Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy

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