A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes

Pereira, Fabiana dos Santos Carolino Firmo; Guimarães, Raphael Mendonça; Lucidi, Alexandre Ramos; Brum, Doralina Guimarães; Paiva, Cláudia N.; Alvarenga, Regina Maria Papais

doi:10.1038/s41598-019-45081-7

Cited by 20 publications

(28 citation statements)

References 54 publications

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“…The highly heterogenous population of Brazil may be relatively more susceptible to some diseases than other populations, and the results of the present study further reinforce the need for the identification of the EUR, AFR and AMR ancestries in a given population in order to best predict the health risks of each individual [ 29 ]. Norris et al .…”

Section: Discussionsupporting

confidence: 60%

Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population

et al. 2020

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In recent years, the incidence of tuberculosis (TB) has declined worldwide, although this disease still occurs at relatively high rates in Amerindian populations. This suggests that the genetic ancestry of Amerindians may be an important factor in the development of infections, and may account for at least some of the variation in infection rates in the different populations. The present study investigated the potential influence of Amerindian genetic ancestry on susceptibility to tuberculosis in an Amazon population. The study included 280 patients diagnosed with tuberculosis and 138 asymptomatic hospital employees with no history of TB, but who were in contact with bacterially active TB patients. Ancestry analysis was run on a set of 61 Ancestry-Informative Markers to estimate European, African, and Amerindian genetic ancestry using STRUCTURE v2.2. The TB group had significantly higher Amerindian ancestry in comparison with the control group, and significantly lower European ancestry. Amerindian ancestry in the 20-60% range was found to be the principal risk factor for increased susceptibility to TB. The results of the study indicate that Amerindian ancestry is an important risk factor for susceptibility to TB in the admixed population of the Brazilian Amazon region.

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Section: Discussionsupporting

confidence: 60%

Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population

et al. 2020

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“…Hispanic Americans represent a heterogenous group with respect to ancestry, with notable differences in cultural/ lifestyle factors and disease prevalence based on country of origin. In particular, Hispanics identifying with the higher Amerind (AI)-ancestry origin have demonstrated enhanced urine albumin excretion 9 , heart failure 10 , lupus erythematosus risk 11 , and prevalence of NAFLD compared to other Hispanic populations 12 , supporting the critical need to conduct studies in these large, rapidly growing populations.…”

Section: Introductionmentioning

confidence: 99%

Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

et al. 2021

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Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk.

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“…It is known the importance of anthropological, historical, linguistic and social impact of this colonization process that occurred in the country. Together with the Europeans and Amerindians, the Africans represent the basis of formation of the Brazilian people [1] [2] [3] [4] [5].…”

Section: Introductionmentioning

confidence: 99%

Population Structure of a Remnant Quilombo Community: An Analysis of the Inbreeding and Ethnic Admixture

Cruz¹,

Lima²,

Sousa³

2020

OALib

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The histories and oral traditions identify rural communities them as quilombos and that are currently denominated quilombo remnants in Brazil. The formation of these communities was usually carried out by a small number of individuals who remained isolated for generations. This study is an analysis of the effects of inbreeding and ethnic admixture in the remaining quilombo community Tucum in the South-Center region of the State of Bahia, in Brazil. The inbreeding values were obtained through inbreeding coefficients and genealogical database. The admixture analysis was conducted by phenotypic and cultural index. Other demographic genetic parameters were evaluated in the search for the better understanding of the population structure. A total of 489 individuals were analyzed for effective population size (N ef), inbreeding coefficient expected (Ø), inbreeding coefficient (F) and mean inbreeding coefficient (F) resulting in 384, 0, 0.144, 0.0086, respectively. The community presents 20.64% of consanguineous marriages and an inbreeding coefficient (r) of 0.288. These data are larger than those found in the total Brazilian population and to other traditional communities analyzed in the country. The admixture analysis revealed a Negroid Phenotypic Index (NPI) of 0.60 and the Negroid Cultural Index (NCI) of 0.33, lower than that found in other remnants. The isolation index (i) helps to understand this pattern of population structure, and the community studied was not a genetic isolate (i = 22.4) demonstrating a large migratory flow. Based on the data presented, it is possible to conclude that the community is not a genetic isolate, transcending the initial implications of the founding effect. However, the high migration does not prevent inbreeding and high rates of consanguineous marriages, influenced by cultural ethnic characters, which may change evolutionary mechanisms, as genetic drift, alleles fixation, natural selection (for preferential selection) and an increase in genetic diseases.

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A systematic literature review on the European, African and Amerindian genetic ancestry components on Brazilian health outcomes

Cited by 20 publications

References 54 publications

Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population

Amerindian genetic ancestry as a risk factor for tuberculosis in an amazonian population

Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations

Population Structure of a Remnant Quilombo Community: An Analysis of the Inbreeding and Ethnic Admixture

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