A Systematic Literature Review on Clinical Research in Human Utilized Electroacupuncture in Korea

Lee, Hyung Geol; Jung, Da Jung; Choi, Yoo Min; Yook, Tae-Han; Song, Beom Yong; Jeong, Seong Gook; Hong, Seung Won; Kim, Jong Uk

doi:10.13045/acupunct.2013053

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…The primary outcome was the ISI score, a validated, selfrating 7-item questionnaire assessing the severity of insomnia and associated daily life disturbances. 32 Total ISI scores ranged from 0 to 28, and were interpreted as follows: no clinically significant insomnia (0-7), subthreshold insomnia (8)(9)(10)(11)(12)(13)(14), moderate insomnia (15)(16)(17)(18)(19)(20)(21), and severe insomnia (22)(23)(24)(25)(26)(27)(28) (follow-up after the final intervention). 33 Secondary outcome measures included the following: (1) the Pittsburgh Sleep Quality Index (PSQI) score, (2) sleep diary-derived variables, (3) HADS score, (4) EuroQoL five dimension (EQ-5D) score, (5) Patient Global Impression of Change (PGIC) score, and (6) salivary melatonin and cortisol levels.…”

Section: Discussionmentioning

confidence: 99%

“…17 Electroacupuncture, a modified form of conventional acupuncture, stimulates acupoints by electrical stimulation via inserted acupuncture needles. 18 Because the body tissue is a type of an electrical conductor, it is believed that electrical impulses can strengthen stimulation through the needles at acupoints. A recent network meta-analysis comparing the effectiveness of different forms of acupuncture in the treatment of insomnia showed that electroacupuncture alleviated insomnia more significantly compared with the conventional acupuncture.…”

Section: Introductionmentioning

confidence: 99%

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<p>Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial</p>

Lee¹,

Kim²,

Jung³

et al. 2020

NSS

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial</p>

Lee¹,

Kim²,

Jung³

et al. 2020

NSS

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“…Acupuncture and electroacupuncture (EA), a combination of acupuncture and electric stimulation [ 13 ], are widely used to the improve quality of life of people with cancer and provide support during conventional treatment such as chemoradiotherapy [ 14 ]. About a third of people with cancer in European countries and 1 in 10 people with cancer in the United States have used acupuncture, with the acupuncture use rate among people with cancer being higher than that in people without cancer [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture for treating cancer-related insomnia: a multicenter, assessor-blinded, randomized controlled, pilot clinical trial

Lee

Kim

et al. 2022

BMC Complement Med Ther

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Background Insomnia is one of the most frequent symptoms in people with cancer. Electroacupuncture has been widely used in people with cancer or insomnia. We explored the feasibility and preliminary effectiveness of electroacupuncture for cancer-related insomnia. Methods People with cancer and insomnia disorder were randomly allocated to electroacupuncture, sham-electroacupuncture, or usual care groups. Participants received either 10 sessions of electroacupuncture at real acupoints, sham-electroacupuncture at non-acupoints, or usual care in each group for 4 weeks. We calculated the recruitment, adherence, and completion rates of participants. The Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), sleep diary and actigraphy-derived sleep parameters, Functional Assessment of Cancer Therapy-Fatigue (FACT-F), Montreal Cognitive Assessment (MoCA), and salivary levels of cortisol and melatonin were evaluated as outcome measures. Results Twenty-two participants were enrolled (8, 6, and 8 respectively in the electroacupuncture, sham-electroacupuncture, and usual care groups) and 20 participants completed the trials (8, 4, and 8 respectively). The recruitment, adherence, and completion rates were 78.57% (22/28), 95.45% (21/22), and 90.91% (20/22), respectively. Most of the participants had previously received conventional treatment for insomnia, but few had received Korean medicine treatment, without any demographic or clinical differences between groups. In the electroacupuncture group, there was a statistically significant reduction of 10.13 (mean) ± 8.15 (standard deviation) and 5 ± 3.70 points in mean ISI and PSQI scores at 4 weeks post-treatment (P = .0098 and .0066), compared with sham-electroacupuncture (2.06 ± 7.15 and 1.61 ± 4.34; P = .4796 and .3632) and usual care (3.25 ± 2.60 and 1.38 ± 2.13; P = .0096 and .1112). Although there was no significant difference in ISI score between groups at 4 weeks post-treatment, the electroacupuncture group continued to improve significantly at 4 weeks’ follow-up, showing borderline and significant differences compared to the sham-electroacupuncture and usual care (P = .0614 and .0015). The FACT-F scores in electroacupuncture group showed a significant improvement compared with the sham-electroacupuncture group (P = .0305). No electroacupuncture-related adverse events were reported. Conclusions Electroacupuncture might be feasible for cancer-related insomnia, despite slow participant recruitment. Additional trials with adequately powered sample sizes and a substantial change to the recruitment procedure are needed. Trial registration Clinical Research Information Service, KCT0002162. Submitted 27 October 2016, Registered 2 December 2016 - Retrospectively registered (The first participant enrolment: 28 November 2016),

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“…12 Moreover, recent studies have also reported the effectiveness of acupuncture in CRCI. [13][14][15][16] Similarly, several studies of electroacupuncture, which stimulate acupoints by electrical stimulation via inserted acupuncture needles, 17 have shown its efficacy in various neurological diseases, including MCI, 18,19 dementia, 20 and Parkinson's disease. 21 Compared with acupuncture, electroacupuncture has reported to produce a higher intensity of stimulation on acupoints and is progressively being widely used for its adjustable strength, frequency and easy quantification in the clinic.…”

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confidence: 99%

Electroacupuncture for Cancer-Related Cognitive Impairment: A Clinical Feasibility Study

et al. 2022

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Background: Cancer-related cognitive impairment (CRCI) is a significant problem for cancer patients, as the number of cancer survivors experiencing cognitive impairments is increasing in the absence of standard treatment. There have been attempts to improve the cognitive function of patients with cancer using acupuncture; however, no studies have been conducted using electroacupuncture. Thus, we designed a preliminary study to investigate the feasibility of a clinical trial using electroacupuncture in CRCI patients. Methods: We conducted a single-arm, pilot, clinical trial to investigate the feasibility of a study protocol for further large-scale clinical trials of electroacupuncture in CRCI patients. All participants were treated with electroacupuncture twice a week for 30 minutes at a time, for 8 weeks on acupoints GV20, GV24, EX-HN1, and GB20, HT7, PC6, and KI3. Both subjective and objective outcomes of cognitive function, quality of life (QoL), and psychological factors were measured in all participants at baseline, week 4, 8, and 12. For safety assessment, vital signs, laboratory examinations, and adverse events (AEs) were observed throughout the trial. Results: A total of 12 participants were enrolled at Daejeon and Dunsan Korean Medicine Hospital of Daejeon University from 21 April 2017 to 31 January 2018. After 8 weeks of treatment, electroacupuncture significantly improved both subjective and objective cognitive outcomes, including the perceived cognitive impairments scale of the Functional Assessment of Cancer Therapy-Cognitive Function, QoL scale of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire-C30, Korean version of Montreal Cognitive Assessment, Boston Naming Test, Seoul Verbal Learning Test, and Rey Complex Figure Test. During the entire trial period, 19 AEs were observed, with no serious AEs. Additionally, it was found that all feasibility outcomes, including recruitment, completion, and adherence rates, achieved successful results as the ratio exceeded 0.8. Conclusion: Our study results revealed that electroacupuncture improved cognitive complaints in cancer patients, and we expect electroacupuncture to be a safe and effective management therapy for CRCI patients. These feasibility trial results will be used as preliminary data for future randomized controlled clinical trials. Trial registration number: Korean Clinical Trial Registry (KCT0002168).

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A Systematic Literature Review on Clinical Research in Human Utilized Electroacupuncture in Korea

Cited by 8 publications

References 12 publications

<p>Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial</p>

<p>Efficacy and Safety of Electroacupuncture for Insomnia Disorder: A Multicenter, Randomized, Assessor-Blinded, Controlled Trial</p>

Electroacupuncture for treating cancer-related insomnia: a multicenter, assessor-blinded, randomized controlled, pilot clinical trial

Electroacupuncture for Cancer-Related Cognitive Impairment: A Clinical Feasibility Study

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