A systematic review and meta-analysis on serum and salivary levels of total antioxidant capacity and C-reactive protein in oral lichen planus patients

Hatami, Masoud; Rezaei, Mahya; Sadeghi, Masoud; Tadakamadla, Jyothi; Pekiner, Filiz Namdar

doi:10.1016/j.archoralbio.2022.105445

Cited by 3 publications

(4 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings here reported revealed among the medwakh smoker group an increased level of metabolites linked with inflammatory mechanism, such as pyroglutamic acid 23 , 24 , deoxyguanosine 25 and anserine 26 . In order to investigate futher an eventual association of metwakh smoking and inflammation, we decided to measure CRP, a widely known clinical indicator of inflammatory conditions 27 , 28 . The levels of salivary CRP were first examined among 10 participants as a pilot study from each group of smokers and compared with non-smokers.…”

Section: Resultsmentioning

confidence: 99%

“…Tobacco smoke induced salivary oxidant generation causes morphological changes in the parenchyma of the salivary glands, decreased salivary secretion that contributes to biochemical alterations in the saliva 33 increased inflammation 35 , changed protein carbonyls, and reduced enzyme activities 36 . The increased salivary CRP at levels reported in previous studies 28 , 37 may serve as a plausible indicator of the inflammatory status of the medwakh smokers since we have excluded the effects of reported periodontal diseases among the study subjects as described in the exclusion criteria. Elevated levels of salivary CRP, a powerful biomarker of oral inflammation, may be a consequence of an oxidative burst caused by medwakh smoking.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth

Rani

Soares

Rahman

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The use of alternative tobacco products, particularly medwakh, has expanded among youth in the Middle East and around the world. The present study is conducted to investigate the biochemical and pathophysiological changes caused by medwakh smoking, and to examine the salivary metabolomics profile of medwakh smokers. Saliva samples were collected from 30 non-smokers and 30 medwakh smokers and subjected to metabolomic analysis by UHPLC-ESI-QTOF-MS. The CRP and Glutathione Peroxidase 1 activity levels in the study samples were quantified by ELISA and the total antioxidant capacity (TAC) by TAC assay kits. Statistical measurements and thorough validation of data obtained from untargeted metabolomics identified 37 uniquely and differentially abundant metabolites in saliva of medwakh smokers. The levels of phthalate, L-sorbose, cytosine, uridine, alpha-hydroxy hippurate, and L-nicotine were noticeably high in medwakh smokers. Likewise, 20 metabolic pathways were differentially altered in medwakh smokers. This study identified a distinctive saliva metabolomics profile in medwakh smokers associated with altered redox homeostasis, metabolic pathways, antioxidant system, and CRP levels. The impact of the altered metabolites in medwakh smokers and their diagnostic utility require further research in large cohorts.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth

Rani

Soares

Rahman

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Given its role in many different clinical conditions, it is emerging as a new diagnostic and prognostic marker [ [29] , [30] , [31] ]. In recent studies, serum and salivary galectin levels were measured using ELISA [ 31 , 32 ], and a significant correlation between the serum and saliva in terms of various biomarker levels was reported [ 33 ]. Similarly, there was no significant difference between the saliva and GCF for different galectin levels or the various inflammation markers investigated [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

The role of salivary galectin-3 and galectin-9 levels in plaque-induced gingivitis and periodontitis

Barut,

Nalbantoğlu,

Korkmaz

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…Other researchers have also used saliva samples to identify fibrinogen fragment D, complement component C3c, and cystatin SA as putative biomarkers for the screening and diagnosis of OLP (73). In the recent literature, researchers (74,75) first concluded that there is an association between serum/saliva levels of multiple pro-inflammatory cytokines and OLP pathogenesis, and then suggested the use of saliva and serum C-Reactive Protein (CRP) and total antioxidant capacity (TAC) in the assessment of OLP development.…”

Section: Other Indexes and Methods For Further Diagnosis Of Olpmentioning

confidence: 99%

Differential genotypes of TNF-α and IL-10 for immunological diagnosis in discoid lupus erythematosus and oral lichen planus: A narrative review

2022

View full text Add to dashboard Cite

Discoid lupus erythematosus and oral lichen planus are chronic systemic immune system-mediated diseases with unclear etiology and pathogenesis. The oral mucosa is the common primary site of pathogenesis in both, whereby innate and adaptive immunity and inflammation play crucial roles. The clinical manifestations of discoid lupus erythematosus on the oral mucosa are very similar to those of oral lichen planus; therefore, its oral lesion is classified under oral lichenoid lesions. In practice, the differential diagnosis of discoid lupus erythematosus and oral lichen planus has always relied on the clinical manifestations, with histopathological examination as an auxiliary diagnostic tool. However, the close resemblance of the clinical manifestations and histopathology proves challenging for accurate differential diagnosis and further treatment. In most cases, dentists and pathologists fail to distinguish between the conditions during the early stages of the lesions. It should be noted that both are considered to be precancerous conditions, highlighting the significance of early diagnosis and treatment. In the context of unknown etiology and pathogenesis, we suggest a serological and genetic diagnostic method based on TNF-α and IL-10. These are the two most common cytokines produced by the innate and adaptive immune systems and they play a fundamental role in maintaining immune homeostasis and modulating inflammation. The prominent variability in their expression levels and gene polymorphism typing in different lesions compensates for the low specificity of current conventional diagnostic protocols. This new diagnostic scheme, starting from the immunity and inflammation of the oral mucosa, enables simultaneous comparison of discoid lupus erythematosus and oral lichen planus. With relevant supportive evidence, this information can enhance physicians’ understanding of the two diseases, contribute to precision medicine, and aid in prevention of precancerous conditions.

show abstract

A systematic review and meta-analysis on serum and salivary levels of total antioxidant capacity and C-reactive protein in oral lichen planus patients

Cited by 3 publications

References 63 publications

Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth

Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth

The role of salivary galectin-3 and galectin-9 levels in plaque-induced gingivitis and periodontitis

Differential genotypes of TNF-α and IL-10 for immunological diagnosis in discoid lupus erythematosus and oral lichen planus: A narrative review

Contact Info

Product

Resources

About