A systematic review and meta-analysis of observational studies on the association between animal protein sources and risk of rheumatoid arthritis

Asoudeh, Farzaneh; Jayedi, Ahmad; Kavian, Zahra; Ebrahimi-Mousavi, Sara; Nielsen, Sabrina Mai; Mohammadi, Hamed

doi:10.1016/j.clnu.2021.05.026

Cited by 17 publications

(9 citation statements)

References 67 publications

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“…Nevertheless, there were also lots of studies suggesting no effect red meat consumption laid on the risk of RA (29,30). A recent meta-analysis analyzed 7 cohorts and 6 casecontrol studies also found no significant association between red meat consumption and the risk of RA (31).…”

Section: Red Meatmentioning

confidence: 99%

Nutrients and rheumatoid arthritis: From the perspective of neutrophils

Shao

Lin

2023

Front. Immunol.

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Neutrophils are considered as core immune cells involve in the early stage of rheumatoid arthritis (RA) and participate in the disease progression. The underlining mechanisms include the elevated chemotaxis and infiltration of neutrophils, the increase in the reactive oxygen species and the promotion of neutrophil extracellular traps formation. Accumulating studies demonstrated the important role of nutrients intake played in the initiation and progression of RA. This study summarized the effects of several macronutrients and micronutrients on regulating RA through the modulation of activated neutrophils and appealed for a healthy diet in RA-risk individuals as well as RA patients.

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Section: Red Meatmentioning

confidence: 99%

Nutrients and rheumatoid arthritis: From the perspective of neutrophils

Shao

Lin

2023

Front. Immunol.

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“…Numerous efforts have been made to improve the cardiovascular risk assessment in rheumatic patients: the EULAR guidelines, which recommend a modified SCORE (mSCORE) in RA patients with a duration of disease of more than 10 years; the QRISK2 and QRISK3 algorithms, which use RA as a CVD risk predictor; and various risk prediction models that include markers such as disease activity, duration, and disability index have predicted the risk of composite CVD events such as MI, stroke, and death during the follow-up period of 3 years. All of these calculators have demonstrated controversial results [ 15 , 22 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk Prediction Parameters for Better Management in Rheumatic Diseases

et al. 2022

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The early detection of cardiovascular disease (CVD) serves as a key element in preventive cardiology. The risk of developing CVD in patients with rheumatic disease is higher than that of the general population. Thus, the objective of this narrative review was to assess and describe updated risk-prediction parameters for CVD in patients suffering from rheumatic diseases, and, additionally, to evaluate therapeutic and risk management possibilities. The processes of recognizing CVD risk factors in rheumatic diseases, establishing diagnoses, and discovering CV risk assessments are currently displeasing in clinical practice; they have a limited clinical impact. A large number of references were found while screening PUBMED, Scopus, and Google scholar databases; the 47 most relevant references were utilized to build up this study. The selection was limited to English language full text articles, RCTs, and reviews published between 2011 and 2021. Multiple imaging techniques, such as ECG, ultrasound, and cIMT, as well as biomarkers like osteoprotegerin cytokine receptor and angiopoietin-2, can be beneficial in both CV risk prediction and in early subclinical diagnosis. Physical exercise is an essential non-pharmacological intervention that can maintain the health of the cardiovascular system and, additionally, influence the underlying disease. Lipid-lowering drugs (methotrexate from the non-biologic DMARDs family as well as biologic DMARDs such as anti-TNF) were all associated with a lower CV risk; however, anti-TNF medication can decrease cardiac compliance and promote heart failure in patients with previously diagnosed chronic HF. Although they achieved success rates in reducing inflammation, glucocorticoids, NSAIDs, and COX-2 inhibitors were correlated with an increased risk of CVD. When taking all of the aforementioned points into consideration, there appears to be a dire need to establish and implement CVD risk stratification models in rheumatic patients.

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“…The narrative data synthesis revealed an association between RA indices and the combinations of adequate physical activity or exercise participation and increased protein intake [21,30]. While some investigators did not confirm an association of protein consumption with RA [48,49], a recent systematic review also showed that products containing high quality proteins (i.e., meat) did not associate with RA [50]. It is therefore likely that the association found in our systematic review may be attributed solely to the favorable effect of physical activity.…”

Section: Completeness and Applicability Of Evidencementioning

confidence: 99%

Combined Effects of Diet and Physical Activity on Inflammatory Joint Disease: A Systematic Review and Meta-Analysis

et al. 2023

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Research evidence suggests that, individually, diet and physical activity are effective interventions for reducing levels of inflammation in inflammatory joint diseases (IJD), however little is known about their combined use. This systematic review and meta-analysis aimed to examine the effects and/or associations of combined diet and physical activity interventions in IJD, specifically rheumatoid arthritis (RA) and the spondyloarthropathies (SpA) (PROSPERO registration number: CRD42022370993). Ten out of 11 eligible studies examined RA patients. We found that a combination of diet/nutrition and physical activity/exercise improved Health Assessment Questionnaire score (standardized mean difference = −1.36, confidence interval (CI) = (−2.43)−(−0.30), I2 = 90%, Z = 2.5, p = 0.01), while surprisingly they increased erythrocyte sedimentation rate (mean difference = 0.20, CI = 0.09–0.31, I2 = 0%, Z = 3.45, p < 0.01). No effects were found on C-reactive protein or weight (p > 0.05) of RA patients. We did not find studies in other IJDs that provided sufficient data for a meta-analysis. The narrative data synthesis provided limited evidence to address our research question. No firm conclusions can be made as to whether the combination of diet/nutrition and physical activity/exercise affects inflammatory load in IJDs. The results of this study can only be used as a means of highlighting the low-quality evidence in this field of investigation and the need for further and better-quality research.

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A systematic review and meta-analysis of observational studies on the association between animal protein sources and risk of rheumatoid arthritis

Cited by 17 publications

References 67 publications

Nutrients and rheumatoid arthritis: From the perspective of neutrophils

Nutrients and rheumatoid arthritis: From the perspective of neutrophils

Cardiovascular Risk Prediction Parameters for Better Management in Rheumatic Diseases

Combined Effects of Diet and Physical Activity on Inflammatory Joint Disease: A Systematic Review and Meta-Analysis

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