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Diabetes, a leading cause of death globally, has different types, with Type 2 Diabetes Mellitus (T2DM) being the most prevalent one. It has been established that variations in the SLC11A1 gene impact risk of developing infectious, inflammatory, and endocrine disorders. This study is aimed to investigate the association between the SLC11A1 gene polymorphisms (rs3731864 G/A, rs3731865 C/G, and rs17235416 + TGTG/− TGTG) and anthropometric and biochemical parameters describing T2DM. Eight hundred participants (400 in each case and control group) were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) and amplification-refractory mutation system-PCR (ARMS-PCR) methods. Lipid profile, fasting blood sugar (FBS), hemoglobin A1c level, and anthropometric indices were also recorded for each subject. Findings revealed that SLC11A1–rs3731864 G/A, –rs17235416 (+ TGTG/− TGTG) were associated with T2DM susceptibility, providing protection against the disease. In contrast, SLC11A1–rs3731865 G/C conferred an increased risk of T2DM. We also noticed a significant association between SLC11A1–rs3731864 G/A and triglyceride levels in patients with T2DM. In silico evaluations demonstrated that the SLC11A2 and ATP7A proteins also interact directly with the SLC11A1 protein in Homo sapiens. In addition, allelic substitutions for both intronic variants disrupt or create binding sites for splicing factors and serve a functional effect. Overall, our findings highlighted the role of SLC11A1 gene variations might have positive (rs3731865 G/C) or negative (rs3731864 G/A and rs17235416 + TGTG/− TGTG) associations with a predisposition to T2DM.

Background: Depression, as the second leading cause of dysfunction, is one of the most common mental health disorders. Given that micronutrients have always played a significant role in all physical and psychological aspects of individuals. This study was conducted to investigate the relationship of dietary intake of Selenium, Magnesium, Zinc, and anthropometric profiles with depression in female students at Zahedan University of Medical Science, Zahedan, Iran. Methods: In this cross-sectional study, 200 female medical students of Zahedan University of Medical Sciences participated. The amount of dietary intake of Selenium, Magnesium, and Zinc were measured by Food Frequency Questionnaire (FFQ). For determining the depression score, Beck anxiety questionnaire was administered. To analyze the data, SPSS 22 software was used. Results: The mean of age, body mass index, waist-to hip ratio and waist-to-height ratio were 23.41 ± 2.26 years, 23.54 ± 4.49 kg/m2, 0.85 ± 0.08, and 0.59±0.10, respectively. The mean daily intake of Magnesium, Zinc, and Selenium were 196.37 ± 42.08 mg, 7.38 ± 3.41 mg, and 106.52 ± 31.69 mg, respectively. The mean of depression score was 31.21±10.58. Zinc and Magnesium intake had a significantly strong inverse relationship with depression score and anthropometric indices. Conclusions: The findings showed that Zinc and Magnesium intake as well as anthropometric indices had a significant inverse relationship with depression score. However, the association between Selenium intake and depression score was not significant.