A systematic review and meta-analysis of the correlation between Helicobacter pylori infection and chronic urticaria

Abstract

Background: A meta-analysis was conducted to examine the correlation between Helicobacter pylori infection and chronic urticaria.Methods: We searched Chinese and English databases, including CNKI, Wanfang, and Weipu, using search terms such as Helicobacter pylori infection, and chronic urticaria for articles published from the establishment of the databases to February 2021 examining the correlation between Helicobacter pylori infection and chronic urticaria. The retrieved articles contained data on Helicobacter pylori infection rates in chronic urticaria cases in different regions of the north and south in China. The retrieved articles underwent strict screenings according to inclusion and exclusion criteria. Revman5.3 software was used to perform a meta-analysis on the data of the included articles.Results: A total of 39 documents were retrieved following the searches. According to the inclusion and exclusion criteria, a total of 6 articles on 6 studies, comprising a total of 1,320 patients, were finally included in the meta-analysis. The results showed that the heterogeneity was high (I 2 =58%). A random-effects model was performed. An analysis of the correlation between Helicobacter pylori infection and chronic urticaria revealed significant differences between the study group and the control group [odds ratio (OR) =3.00; 95% confidence interval (CI): 1.98-4.55; P<0.00001]. The infection rate of Helicobacter pylori among chronic urticaria cases in the northern population was 16.1% (95% CI: 15.6-16.6%); of these patients 12.2% were male and 21.4% were female. The infection rate of Helicobacter pylori among chronic urticaria cases in the southern population was 18.0% (95% CI: 17.5-18.5%); of these patients, 12.3% were male and 23.1% were female. There was no significant difference in the prevalence between the male population, the female population, and the general population in the north and the south (P>0.05).Discussion: Helicobacter pylori infection is correlated with the occurrence of chronic urticaria. There is no significant difference in the infection rate of Helicobacter pylori in chronic urticaria cases in different regions of the north and south. This study had some limitations. First, the number of patients included in each study was low, which may affect the accuracy of the results. Second, the detection methods were not uniform; thus, further research is required to support the conclusions drawn.

Clinical Features of Urticaria: Results From a Hospital-Based Multicenter Study in China

“…A representative sample of 57,779 adults aged 20 years or older were recruited for the study by the national cross-sectional China Pulmonary Health (CPH), which showed that the overall prevalence of allergic rhinitis was 3.06% ( 20 ), which was much lower than our study. In respect of eczema and asthma, our results are similar to those reported by other studies ( 21 ).…”

Helicobacter Pylori and Autoimmune Diseases: Involving Multiple Systems

“…Another meta-analysis in which 965 CU patients and 1235 controls were involved in 16 clinical trials indicated that, though weakly, the infection of H. pylori is of an obvious effect on the increased risk of CU ( 151 ). A meta-analysis of 1320 patients enrolled by Magen et al showed that the infection of H. pylori was related to the development of CU ( 152 ). Meanwhile, relevant researches have found that the elimination of H. pylori can do help to evaluate the prognosis of CU and may reduce the recurrence rate of chronic urticaria ( 153 , 154 ).…”

Reappraisal of the role of Helicobacter pylori in chronic spontaneous urticaria

“…1, 7 Multiple studies have found a positive link between the presence of HP and the development of CU, and the commencement of HP eradication therapy has been shown to be beneficial in reducing symptoms in certain patients. [8][9][10][11][12][13] On the other hand, a number of additional studies have been unable to establish a statistically significant correlation between HP infection and CSU, and the complete eradication of HP has not consistently resulted in the resolution of CSU in all individuals. [14][15][16] Also, a recent meta-analysis reported that CSU patients who received antibiotic therapy for the eradication of HP demonstrated a notably higher rate of CSU remission, regardless of whether HP eradication was achieved or not.…”