High-quality systematic literature reviews provide a systematic process for identifying, synthesizing, and critiquing multiple studies and, in turn, inform theory, research, practice, and policy. With a focus on special education systematic reviews, we propose four core principles (i.e., coherence, contextualization, generativity, and transparency) to guide scholars in conducting meta-analyses, systematic narrative reviews, and qualitative meta-syntheses. Specifically, we articulate how scholars can promote each of these principles at each stage of the review process to enhance the rigor, relevance, and credibility of their systematic review: (a) framing the problem and research questions; (b) planning procedures to identify, analyze, and synthesize studies; and (c) presenting and interpreting results. Last, we discuss future directions in light of issues of equity and approaches to bridge synthesis findings and practice and policy.