A systematic review and meta-analysis on Staphylococcus aureus carriage in psoriasis, acne and rosacea

Totté, J.E.E.; Feltz, W.T. van der; Bode, L.; Belkum, Alex van; Zuuren, Esther J van; Pasmans, Suzanne G.M.A.

doi:10.1007/s10096-016-2647-3

Cited by 39 publications

(40 citation statements)

References 66 publications

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“…Although more than 30% of healthy individuals are colonized asymptomatically by S. aureus 75,76 , it can cause a wide spectrum of infections: some are limited to a single hair follicle (furuncle), others involve subcutaneous tissues (cellulitis), and the most serious feature potentially fatal penetration into any organ in the body, including bone (osteomyelitis), bloodstream (bacterial sepsis), and heart valves (bacterial endocarditis). S. aureus has also been implicated in the pathogenesis of chronic diseases such as atopic dermatitis 22,77–79 , and more recently in systemic lupus erythematosus with renal and skin involvement 80 .…”

Section: Host–pathogen Interactionsmentioning

confidence: 99%

Skin microbiota–host interactions

Chen

Fischbach

Belkaid

2018

Nature

539

396

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The skin is a complex and dynamic ecosystem that is inhabited by bacteria, archaea, fungi and viruses. These microbes—collectively referred to as the skin microbiota—are fundamental to skin physiology and immunity. Interactions between skin microbes and the host can fall anywhere along the continuum between mutualism and pathogenicity. In this Review, we highlight how host–microbe interactions depend heavily on context, including the state of immune activation, host genetic predisposition, barrier status, microbe localization, and microbe–microbe interactions. We focus on how context shapes the complex dialogue between skin microbes and the host, and the consequences of this dialogue for health and disease.

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Section: Host–pathogen Interactionsmentioning

confidence: 99%

Skin microbiota–host interactions

Chen

Fischbach

Belkaid

2018

Nature

539

396

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“…Few studies which investigated this subject revealed increased skin colonization with S. aureus (Tomi et al 2005; Totté et al 2016b)—in more than 50% of psoriatics (reaching 100% of those with erythroderma) vs. 12% of healthy controls. Moreover, disease activity was significantly correlated with toxogenic strains (Balci et al 2009; Tomi et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis

Wawrzycki

Pietrzak

Grywalska

et al. 2018

Arch. Immunol. Ther. Exp.

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Psoriasis is a chronic debilitating skin disease with an estimated prevalence reaching 2% of the worldwide population. Psoriatic disease is driven by a network of complicated reciprocal interactions among innate and adaptive mechanisms of immune system with structural components of the skin. Interleukin (IL)-22 mediates keratinocyte proliferation and epidermal hyperplasia, inhibits terminal differentiation of keratinocytes, and induces the production of antimicrobial proteins. The aim of this study was the assessment of IL-22 levels and its correlation with disease activity in plaque psoriasis. The study group included 64 patients with mild, moderate and severe psoriasis. Control group was composed of 24 sex- and age-matched healthy volunteers. IL-22 concentration was assessed in supernatants of T-cell cultures as well as in the plasma of study and control group with the use of ELISA method. Statistical analysis showed that concentration of IL-22 in cultures exposed to staphylococcal enterotoxin B was significantly higher than in control samples (p = 0.005) and cultures treated with IL-12 (p = 0.005). Patients with psoriasis presented significantly higher concentrations of IL-22 than healthy individuals (p = 0.0000001). In conclusion, IL-22 may collaborate with other soluble factors and cells together forming inflammatory circuits that otherwise exist as constitutive or inducible pathways in normal skin and become pathologically amplificated in psoriasis. Targeting IL-22 may be promising as a potential therapeutic for plaque psoriasis.

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“…Increased colonization of S . aureus in psoriatic skin has been reported previously in several small studies, but only a few of these examined unaffected skin from psoriasis patients [ 44 ]. Our data revealed a significant increase of colonization in both psoriatic lesional and non-lesional sites compared to the baseline levels of S .…”

Section: Discussionmentioning

confidence: 99%

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization

et al. 2018

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BackgroundPsoriasis impacts 1–3% of the world’s population and is characterized by hyper-proliferation of keratinocytes and increased inflammation. At the molecular level, psoriasis is commonly driven by a Th17 response, which serves as a major therapeutic target. Microbiome perturbations have been associated with several immune-mediated diseases such as atopic dermatitis, asthma, and multiple sclerosis. Although a few studies have investigated the association between the skin microbiome and psoriasis, conflicting results have been reported plausibly due to the lack of standardized sampling and profiling protocols, or to inherent microbial variability across human subjects and underpowered studies. To better understand the link between the cutaneous microbiota and psoriasis, we conducted an analysis of skin bacterial communities of 28 psoriasis patients and 26 healthy subjects, sampled at six body sites using a standardized protocol and higher sequencing depth compared to previous studies. Mouse studies were employed to examine dermal microbial-immune interactions of bacterial species identified from our study.ResultsSkin microbiome profiling based on sequencing the 16S rRNA V1–V3 variable region revealed significant differences between the psoriasis-associated and healthy skin microbiota. Comparing the overall community structures, psoriasis-associated microbiota displayed higher diversity and more heterogeneity compared to healthy skin bacterial communities. Specific microbial signatures were associated with psoriatic lesional, psoriatic non-lesional, and healthy skin. Specifically, relative enrichment of Staphylococcus aureus was strongly associated with both lesional and non-lesional psoriatic skin. In contrast, Staphylococcus epidermidis and Propionibacterium acnes were underrepresented in psoriatic lesions compared to healthy skin, especially on the arm, gluteal fold, and trunk. Employing a mouse model to further study the impact of cutaneous Staphylcoccus species on the skin T cell differentiation, we found that newborn mice colonized with Staphylococcus aureus demonstrated strong Th17 polarization, whereas mice colonized with Staphylococcus epidermidis or un-colonized controls showed no such response.ConclusionOur results suggest that microbial communities on psoriatic skin is substantially different from those on healthy skin. The psoriatic skin microbiome has increased diversity and reduced stability compared to the healthy skin microbiome. The loss of community stability and decrease in immunoregulatory bacteria such as Staphylococcus epidermidis and Propionibacterium acnes may lead to higher colonization with pathogens such as Staphylococcus aureus, which could exacerbate cutaneous inflammation along the Th17 axis.Electronic supplementary materialThe online version of this article (10.1186/s40168-018-0533-1) contains supplementary material, which is available to authorized users.

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A systematic review and meta-analysis on Staphylococcus aureus carriage in psoriasis, acne and rosacea

Cited by 39 publications

References 66 publications

Skin microbiota–host interactions

Skin microbiota–host interactions

Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis

Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization

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