A Systematic Review and Meta-Analysis on the Epidemiology of Hepatitis B and Hepatitis C Virus among Beta-Thalassemia Major Patients in Pakistan

Waheed, Usman; Saba, Noore; Wazeer, Akhlaaq; Ahmed, Salman

doi:10.1055/s-0041-1731110

Cited by 8 publications

(7 citation statements)

References 29 publications

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“…Most patients (85.5%) had no comorbidities besides beta-thalassemia. Among the comorbidities found, the high prevalence of HCV (7.3%) among these patients was consistent with previous studies in Pakistan [ 27 , 28 ]. The second most prevalent comorbidity was autoimmune hemolytic anemia (AIHA) at 3.6%.…”

Section: Discussionsupporting

confidence: 91%

Correlation Between Serum Ferritin and Degree of Hepatic Fibrosis on Fibroscan in Thalassemic Patients

Ali¹,

Borhany²,

Butt³

et al. 2023

Cureus

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Aim and objective This study aimed to examine the relationship between serum ferritin levels and the degree of hepatic fibrosis as detected on Fibroscan in thalassemia patients. Materials and methods This was a single-center and cross-sectional study conducted from April 2021 to December 2022. The sample population comprised 55 beta-thalassemia patients receiving treatment at the National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan. The data was compiled through a series of patient interviews, an examination of medical records and was analyzed to obtain the results. Descriptive statistics were used for several variables, including diagnosis, Fibroscan score, blood group, comorbidity, visceromegaly, consanguinity, serum glutamate pyruvate transaminase (SGPT), viral markers, and C reactive protein (CRP). The correlation analysis was done using Spearman’s correlation test. Results There were 55 participants in the study, 40 of whom were male and 15 of whom were female. The mean age of the patients was eight years, while the average age at diagnosis was nine months with a transfusion frequency of every 20 days. Spearman's rho (r = 0.287), and the significant value of (p = 0.033) confirmed a statistically significant positive correlation between serum ferritin levels and hepatic fibrosis. On Fibroscan, 74.5% of patients had F0-F1 stage fibrosis followed by 14.5% of the patients having F2 stage fibrosis. HCV seropositivity was the most prevalent comorbidity among the patients. 80% of patients had serum ferritin levels greater than 1000 ug/mL. Hepatosplenomegaly was present in 43.6% of the patients. 78.2% of patients were born out of consanguineous marriages. Conclusion In conclusion, this study found a statistically significant positive correlation between serum ferritin levels and hepatic fibrosis in beta-thalassemia patients. The study emphasizes the significance of monitoring serum ferritin levels in thalassemia patients to prevent hepatic fibrosis.

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Section: Discussionsupporting

confidence: 91%

Correlation Between Serum Ferritin and Degree of Hepatic Fibrosis on Fibroscan in Thalassemic Patients

Ali¹,

Borhany²,

Butt³

et al. 2023

Cureus

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“…and Akhtar et al2 Also study done by Waheed et al9 showed prevalence of 29.79% which in accordance with our results. Study done in Peshawar by Al-Moshary et al11 showed prevalence of HCV at 23.66%, HBV 4.87% and HIV 1.39% and these figures are in conformity with our results.…”

supporting

confidence: 92%

Prevalence of Hepatitis B and C in Patients of Thalassemia in Sargodha, Pakistan

Aiman¹,

Liaqat²,

Bushra³

et al. 2022

PJMHS

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Background: Thalassemia is one of the commonest genetic hematological disorders and a health issue of global concern. Because of repeated blood transfusions, ratio of hepatitis B and C positivity is escalating in these patients day by day who have further complicated the situation in the form of poor treatment outcomes and costs to individuals Aim: To measure the prevalence of hepatitis B and C among patients of thalassemia major in Sargodha, Pakistan. Study design: Cross-sectional study Place and duration of study: Rai Hospital & Hilal-e-Ahmar Hospital, Sargodha from 01-01-20221 to 31-12- 2021. Methodology: Three hundred and sixty thalassemia major patients, both beta and alpha, confirmed on hemoglobin electrophoresis admitted in the hospital were enrolled. Results: The mean age of the participants was 10.24±2.5 years, and 50% were male and 50% females. About 34% of the patients had hepatitis in which 30% had hepatitis C and 1.1% hepatitis B. 2.2% had both. Conclusion: Hepatitis b and C are highly prevalent among patients of thalassemia major. This also calls physicians, hematologists, pediatricians and policy makers to focus on counseling and support of thalassemia patients by providing them safe blood. Keywords: Prevalence, Hepatitis B and C, Thalassemia major, Blood transfusion

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“…This is an encouraging finding from a low-income country like Afghanistan. This percentage of voluntary blood donations, although still far from WHO’s goal of 100% VNRBD, 14 is better than regional countries including Pakistan, 15 and Bangladesh. 16 …”

Section: Discussionmentioning

confidence: 76%

First Report from Afghanistan on the Prevalence of Blood-Borne Infections: A Retrospective Cross-Sectional Multicentre Study for an Epidemiological Assessment

Hashemi¹,

Waheed²,

Saba³

et al. 2022

JBM

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Background The transfusion of blood and blood components has a significant role in healthcare services. However, it remains a possible risk factor for blood-borne infections. The present study was conducted to assess the prevalence of serological markers of common blood-borne infections among the blood donor population of Afghanistan. Methodology This was a cross-sectional study based on retrospectively collected data over a period of six years from 284 blood centres across 34 provinces of Afghanistan. Every blood donor’s sample was tested by rapid immunoassays for the serological markers of blood-borne infections namely hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (anti-HCV), anti-human immunodeficiency virus 1/2 (anti-HIV1/2), and anti-Treponema pallidum (anti-TP). Results All blood donors during the study period were males. The majority of blood donations were from the family replacement category 56.93% (n = 544,568). The overall pooled prevalence of blood-borne infections was 4.36% with a comparatively higher percentage in family replacement donors 4.88%. The seropositivity for HBsAg, anti-HCV, anti-HIV1/2, and anti-TP was 2.95%, 0.81%, 0.04%, and 0.54%, respectively. Conclusion Complete reliance on voluntary blood donors and screening with quality assured highly sensitive assay is recommended to ensure blood safety in the country.

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A Systematic Review and Meta-Analysis on the Epidemiology of Hepatitis B and Hepatitis C Virus among Beta-Thalassemia Major Patients in Pakistan

Cited by 8 publications

References 29 publications

Correlation Between Serum Ferritin and Degree of Hepatic Fibrosis on Fibroscan in Thalassemic Patients

Correlation Between Serum Ferritin and Degree of Hepatic Fibrosis on Fibroscan in Thalassemic Patients

Prevalence of Hepatitis B and C in Patients of Thalassemia in Sargodha, Pakistan

First Report from Afghanistan on the Prevalence of Blood-Borne Infections: A Retrospective Cross-Sectional Multicentre Study for an Epidemiological Assessment

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