A systematic review of electrocardiographic changes in healthy high-altitude populations

Parodi, Josefina; Ramchandani, Rashi; Zhou, Zier; Azanza, Diego Xavier Chango; Acunzo, Rafael S.; Liblik, Kiera; Farina, Juan; Zaidel, Ezequiel; Mori, Enrique Ruiz; Carreón, José M Arce; Liprandi, Álvaro Sosa; Baranchuk, Adrián

doi:10.1016/j.tcm.2022.01.013

Cited by 10 publications

(2 citation statements)

References 31 publications

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“…High altitudes can induce alterations in cardiac electrophysiology parameters (Parodi et al, 2022). Therefore, we applied ECG to detect the changes in cardiac electrical conduction function in different groups.…”

Section: Resultsmentioning

confidence: 99%

Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats

Zhao

Jia

Shen

et al. 2023

Phytotherapy Research

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High‐altitude cardiac injury (HACI) is one of the common tissue injuries caused by high‐altitude hypoxia that may be life threatening. Notoginsenoside R1 (NG‐R1), a major saponin of Panax notoginseng, exerts anti‐oxidative, anti‐inflammatory, and anti‐apoptosis effects, protecting the myocardium from hypoxic injury. This study aimed to investigate the protective effect and molecular mechanism of NG‐R1 against HACI. We simulated a 6000 m environment for 48 h in a hypobaric chamber to create a HACI rat model. Rats were pretreated with NG‐R1 (50, 100 mg/kg) or dexamethasone (4 mg/kg) for 3 days and then placed in the chamber for 48 h. The effect of NG‐R1 was evaluated by changes in Electrocardiogram parameters, histopathology, cardiac biomarkers, oxidative stress and inflammatory indicators, key protein expression, and immunofluorescence. U0126 was used to verify whether the anti‐apoptotic effect of NG‐R1 was related to the activation of ERK pathway. Pretreatment with NG‐R1 can improve abnormal cardiac electrical conduction and alleviate high‐altitude‐induced tachycardia. Similar to dexamethasone, NG‐R1 can improve pathological damage, reduce the levels of cardiac injury biomarkers, oxidative stress, and inflammatory indicators, and down‐regulate the expression of hypoxia‐related proteins HIF‐1α and VEGF. In addition, NG‐R1 reduced cardiomyocyte apoptosis by down‐regulating the expression of apoptotic proteins Bax, cleaved caspase 3, cleaved caspase 9, and cleaved PARP1 and up‐regulating the expression of anti‐apoptotic protein Bcl‐2 through activating the ERK1/2‐P90RSK‐Bad pathway. In conclusion, NG‐R1 prevented HACI and suppressed apoptosis via activation of the ERK1/2‐P90RSK‐Bad pathway, indicating that NG‐R1 has therapeutic potential to treat HACI.

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Section: Resultsmentioning

confidence: 99%

Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats

Zhao

Jia

Shen

et al. 2023

Phytotherapy Research

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“…The increased STR may be due to the decreased velocity of myocardial fiber shortening during the ejection period 33 . Notably, the QTc interval was also significantly prolonged by half of expeditioners (over 440 ms), indicating increased cardiovascular morbidity risk 34 .…”

Section: Discussionmentioning

confidence: 99%

Association of attenuated leptin signaling pathways with impaired cardiac function under prolonged high-altitude hypoxia

Wang,

Liu,

Sun

et al. 2024

Sci Rep

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Cardiovascular function and adipose metabolism were markedly influenced under high altitudes. However, the interplay between adipokines and heart under hypoxia remains to be elucidated. We aim to explore alterations of adipokines and underlying mechanisms in regulating cardiac function under high altitudes. We investigated the cardiopulmonary function and five adipokines in Antarctic expeditioners at Kunlun Station (4,087 m) for 20 days and established rats exposed to hypobaric hypoxia (5,000 m), simulating Kunlun Station. Antarctic expeditioners exhibited elevated heart rate, blood pressure, systemic vascular resistance, and decreased cardiac pumping function. Plasma creatine phosphokinase-MB (CK-MB) and platelet-endothelial cell adhesion molecule-1 (sPecam-1) increased, and leptin, resistin, and lipocalin-2 decreased. Plasma leptin significantly correlated with altered cardiac function indicators. Additionally, hypoxic rats manifested impaired left ventricular systolic and diastolic function, elevated plasma CK-MB and sPecam-1, and decreased plasma leptin. Chronic hypoxia for 14 days led to increased myocyte hypertrophy, fibrosis, apoptosis, and mitochondrial dysfunction, coupled with reduced protein levels of leptin signaling pathways in myocardial tissues. Cardiac transcriptome analysis revealed leptin was associated with downregulated genes involved in rhythm, Na+/K+ transport, and cell skeleton. In conclusion, chronic hypoxia significantly reduced leptin signaling pathways in cardiac tissues along with significant pathological changes, thus highlighting the pivotal role of leptin in regulation of cardiac function under high altitudes.

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A Systematic Review of Electrocardiographic Changes in Populations Temporarily Ascending to High Altitudes

Ramchandani

Zhou

Parodi

et al. 2023

Current Problems in Cardiology

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A systematic review of electrocardiographic changes in healthy high-altitude populations

Cited by 10 publications

References 31 publications

Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats

Pretreatment with Notoginsenoside R1 attenuates high‐altitude hypoxia‐induced cardiac injury via activation of the ERK1/2‐P90RSK‐Bad signaling pathway in rats

Association of attenuated leptin signaling pathways with impaired cardiac function under prolonged high-altitude hypoxia

A Systematic Review of Electrocardiographic Changes in Populations Temporarily Ascending to High Altitudes

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