A systematic review of intravenous immunoglobulin for treatment of unexplained recurrent miscarriage

Ata, Barış; Tan, Seang Lin; Shehata, Fady; Holzer, Hananel; Buckett, William

doi:10.1016/j.fertnstert.2010.12.021

Cited by 83 publications

(59 citation statements)

References 28 publications

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“…A recent randomized, multi-centred, double-blinded, placebo-controlled trial and meta-analysis [137] did not report any treatment benefit for intravenous immunoglobulin (IVIG) in patients with idiopathic unexplained RSM. Further, another systematic review [138] reported no beneficial effect of IVIG in the treatment of unexplained RSM. However, in a previous study by Christiansen et al [139], the authors had demonstrated an enhanced pregnancy outcome for patients with secondary RSM who were treated with IVIG (58% successful pregnancy rate in treated patients vs. 24% pregnancy in placebo-treated patients; p < 0.02), and a meta-analysis of 8 randomized controlled studies [140] also confirmed a positive benefit for the use of IVIG in idiopathic RSM.…”

Section: The Role Of Other Forms Of Therapy Using Immunologically Relmentioning

confidence: 99%

Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire

Diejomaoh¹

2014

Med Princ Pract

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Recurrent spontaneous miscarriage (RSM), affecting 1-2% of women of reproductive age seeking pregnancy, has been a clinical quagmire and a formidable challenge for the treating physician. There are many areas of controversy in the definition, aetiology, investigations and treatment of RSM. This review will address the many factors involved in the aetiology of RSM which is multifactorial in many patients, with antiphospholipid syndrome (APS) being the most recognized aetiological factor. There is no identifiable cause in about 40-60% of these patients, in which case the condition is classified as idiopathic or unexplained RSM. The RSM investigations are extensive and should be undertaken in dedicated, specialized, well-equipped clinics/centres where services are provided by trained specialists. The challenges faced by the treating physician are even more overwhelming regarding the decision of what should be the most appropriate therapy offered to patients with RSM. Our review will cover the diverse modalities of therapy available including the role of preimplantation genetic testing using recent microarray technology, such as single nucleotide polymorphism and comparative genomic hybridization, as well as preimplantation genetic diagnosis; the greatest emphasis will be on the treatment of APS, and there will be important comments on the management of patients presenting with idiopathic RSM. The controversial areas of the role of natural killer cells in RSM, the varied modalities in the management of idiopathic RSM and the need for better-planned studies will be covered as well.

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Section: The Role Of Other Forms Of Therapy Using Immunologically Relmentioning

confidence: 99%

Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire

Diejomaoh¹

2014

Med Princ Pract

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“…A meta-analysis showed that the use of IVIG improved the live birth rates in women with secondary RM compared to placebo, but the effect was not significant [22] . The use of unfractionated or LMWH in mice prevent complement activation, and pregnancy complications caused by IgG from women with APS [23] .…”

Section: [Evidence 1++]mentioning

confidence: 99%

Miscarriage Definitions, Causes and Management: Review of Literature

2017

ARC Journal of Gynecology and Obstetrics

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“…(GRADE A1) 305,306 Agradecimientos Esta guía fue desarrollada gracias al apoyo irrestricto de Shire Colombia.…”

Section: Misceláneosunclassified

Guía colombiana de práctica clínica para el uso de inmonuglobulinas en el tratamiento de reemplazo e inmunomodulación

Olivares

Olmos²,

Álvarez

et al. 2017

RAM

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Immunoglobulins are heterodimeric proteins composed of 2 heavy chains and 2 light chains. Human immunoglobulin G (IgG) is a plasma derivative and contains more than 95% of IgG. The composition of IgG subclasses is similar to that of normal human plasma. Immunoglobulin therapy was first introduced more than 50 years ago, and its use has been described in numerous diseases. In Colombia, the importance of this immunomodulatory resource prompted the need for clinical practice guidelines to be available for its use. For this reason, a multidisciplinary group of experts was brought together and distributed in working groups, by specialties, in order to develop an initial manuscript. Systematic literature searches were undertaken; identified evidences were evaluated and classified to support a preliminary draft that was discussed, analyzed and amended. Recommendations were issued on the use of intravenous immunoglobulin in pathologies that include primary and secondary immunodeficiencies, autoimmune diseases, neurological disorders, infections, transplants and miscellaneous conditions; grades were assigned to each one of them according to the GRADE system. The final result translated into recommendations that are put forth with the purpose to inform, guide and support on optimal use of this immunomodulatory resource.

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A systematic review of intravenous immunoglobulin for treatment of unexplained recurrent miscarriage

Cited by 83 publications

References 28 publications

Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire

Recurrent Spontaneous Miscarriage Is Still a Challenging Diagnostic and Therapeutic Quagmire

Miscarriage Definitions, Causes and Management: Review of Literature

Guía colombiana de práctica clínica para el uso de inmonuglobulinas en el tratamiento de reemplazo e inmunomodulación

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