A Systematic Review of Management of Oral Lichen Planus

Jena, Ashok Kumar; Das, Sharmistha

doi:10.14260/jemds/2016/415

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Keratinosit bersama dengan sel T menjadi perantara kematian sel basal yang memicu apoptosis. 13,14,15,16 Etiopatogenesis OLP dipengaruhi oleh beberapa faktor seperti genetik, obat-obatan, alergi makanan, bahan gigi, imunodefisiensi, autoimunitas, stres, neoplasma ganas dan beberapa kondisi sistemik seperti diabetes dan hipertensi, dan penyakit usus. 17,18 Ada enam bentuk klinis OLP diantaranya reticular, erosive, papula, bula, plak, atropi.…”

Section: Diskusiunclassified

“…Salep ini terbukti efektif dalam mengurangi eritema dan ulserasi pada mukosa mulut. 16 Namun pada kasus ini, perbaikan belum terlihat signifikan saat kontrol di bulan kelima. Kondisi ini dapat disebabkan berbagai faktor seperti degradasi enzimatik, lokasi yang sulit dijangkau, penetrasi obat ke jaringan yang tidak adekuat dan terbilasnya obat oleh saliva.…”

Section: Diskusiunclassified

“…Cmc berfungsi sebagai orabase, sehingga merekat erat pada permukaan mukosa mulut. 16 Pasta adhesif yang merupakan bahan bioadhesif diketahui dapat meningkatkan retensi obat pada mukosa mulut. 12 Pullulan merupakan exopolysaccharide fleksibel, non-imunogenik struktural dengan sifat perekat basah-lengket dan telah banyak digunakan untuk pengiriman obat (drug delivery) pada permukaan basah rongga bukal.…”

Section: Diskusiunclassified

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Tantangan Farmakologi Penggunaan Steroid Topikal Pada Pasien Oral Lichen Planus

Nelonda

Nur’aeny

Sufiawati

2019

ODONTO : Dental Journal

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Background: Oral lichen planus (OLP) is a chronic autoimmune disease sprinkled by T cells on the oral mucosal surface. The goal of OLP treatment is to eliminate erythema, ulceration and relieve symptoms. Corticosteroids are the first line in the treatment of OLP, either systemically or topically. The problem arises when using topical steroids, namely the time of topical steroid attachment to the oral mucosa, especially in cases of OLP with clinical desquamative gingivitis. Some studies suggest that the use of individual gingival tray can overcome this problem. Objective: To provide information on topical steroid use in OLP cases with desquamative gingivitis clinical signs.Case Management: Women, age 31, complain that pain with burning on the lips and mouth is aggravated by spicy food. Intraoral examination shows irregular white plaques on the buccal, labial and dorsal mucosa of the tongue accompanied by diffuse erythema in the anterior gingiva of the upper and lower jaws. Patients diagnosed with OLP. Lesions improve 3 months after topical steroid administration, except lesions on the gingiva. Gingival individual tray is then used to obtain adequate attachment of topical steroids on the gingiva surface. The gingiva showed significant improvement after a month later.Conclusion: The use of topical steroid concoctions applied to the gingival individual tray is effective in treating OLP lesions especially with clinical signs of desquamative gingivitis.

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Tantangan Farmakologi Penggunaan Steroid Topikal Pada Pasien Oral Lichen Planus

Nelonda

Nur’aeny

Sufiawati

2019

ODONTO : Dental Journal

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Emerging potential of phototherapy in management of symptomatic oral lichen planus: A systematic review of randomised controlled clinical trials

Hanna

Dalvi²,

Tomov

et al. 2023

Journal of Biophotonics

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Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial

Bakhshi

Gholami

Mahboubi

et al. 2020

Dermatology Research and Practice

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Objectives. This study aimed to evaluate the efficacy of a combination of 1% nanocurcumin gel with 0.1% triamcinolone acetonide mouth rinse for oral lichen planus (OLP). Materials and Methods. This double-blind randomized clinical trial was conducted on 31 patients with erosive or ulcerative OLP. All patients received 0.1% triamcinolone mouth rinse and were then randomly divided into two groups for combination therapy with (I) %1 nanocurcumin gel or (II) placebo gel. The reticular-erosive-ulcerative (REU) score was calculated at baseline and at two and four weeks after the intervention. The changes in the mean REU score and the efficacy index were calculated to determine the level of improvement after two and four weeks. Data were analyzed using independent t-test, repeated measures ANCOVA, Mann–Whitney test, and chi-square test. P<0.05 was considered statistically significant. Results. There were 14 patients in the nanocurcumin and 17 patients in the placebo group. A significantly higher decrease in the mean REU score was observed in the nanocurcumin compared with the placebo group (P<0.001). The efficacy index was significantly higher in the nanocurcumin group (P<0.001). Conclusion. Application of 1% nanocurcumin in combination with 0.1% triamcinolone acetonide can serve as an effective treatment strategy to enhance the level of improvement of lesions compared with the use of triamcinolone acetonide alone.

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A Systematic Review of Management of Oral Lichen Planus

Cited by 3 publications

References 36 publications

Tantangan Farmakologi Penggunaan Steroid Topikal Pada Pasien Oral Lichen Planus

Tantangan Farmakologi Penggunaan Steroid Topikal Pada Pasien Oral Lichen Planus

Emerging potential of phototherapy in management of symptomatic oral lichen planus: A systematic review of randomised controlled clinical trials

Combination Therapy with 1% Nanocurcumin Gel and 0.1% Triamcinolone Acetonide Mouth Rinse for Oral Lichen Planus: A Randomized Double-Blind Placebo Controlled Clinical Trial

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