A Systematic Review of Pharmacoeconomic Studies for Pregabalin

Abstract

Neuropathic pain and FM are associated with high healthcare resource use and costs. Economic studies of pregabalin in neuropathic pain and FM indicate some results favorable to other forms of care, but heterogeneity among study designs and populations hinder comparisons. Future economic analyses should aim to address data gaps regarding effects of pregabalin on productivity and resource use.

Cost-Utility of Group Acceptance and Commitment Therapy for Fibromyalgia Versus Recommended Drugs: An Economic Analysis Alongside a 6-Month Randomized Controlled Trial Conducted in Spain (EFFIGACT Study)

“…16,27 A recent network meta-analysis and cost-effectiveness analysis of new generation antidepressants indicated that duloxetine was the least well tolerated drug analysed,16 while Parker and colleagues27 concluded that more studies with favourable results are needed before pregabalin can be considered a cost-effective treatment option. Only 39 patients (25% of our sample) presented comorbid major depression, so we were underpowered to perform a cost-effectiveness analysis considering this subgroup of patients.…”

Comparative studies on novel combinations of pregabalin plus venlafaxine with standard diazepam and marketed combination of alprazolam plus sertraline for anxiety disorders

“…The present study assessed anxiolytic activity of different combinations of PGL & VLF using two classical animal models of anxiety, the EPM model, based on the natural aversion of rodents for height and open spaces and the L&D test, which uses the aversion of rodents for brightly lit spaces [13][14][15] dose adjustment in renal impairment and rapidly crosses BB [9][10] .…”

“…Copyright © 2018 Rahul P. Pol et al doi: 10.24294/as.v1i3.977 EnPress Publisher LLC.This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). http://creativecommons.org/licenses/ by/4.0/ pharmacodynamic profile and its clinical effectiveness in not only limited to anxiety but other disorders also, while Venlafaxine gives the advantage of its serotonin plus noradrenaline reuptake inhibiting property [5][6][7][8][9][10][11] . Hence taking these encouraging facts into considerations the present study was designed for evaluation of beneficial effects of co administration of these two drugs Pregabalin and Venlafaxine.…”

“…The evolving science and our understanding of utility of Pregabalin and Venlafaxine might represent a path forward to such a goal [8][9][10][11] . Because Pregabalin proven to have early onset of action in clinical studies and acts via novel receptor, while Venlafaxine has unique dose dependent blockade of serotonin, Norepinephrine & Dopamine which is effective in comorbid generalized anxiety disorder with depression [11] .…”

Dosing Time-Dependent Changes in the Analgesic Effect of Pregabalin on Diabetic Neuropathy in Mice

“…The mainstay treatment of diabetes-induced neuropathic pain is pharmacotherapy. Pregabalin [PGN; (S)-3-(aminomethyl)-5-methylhexanoic acid] is now widely used to alleviate diabetic peripheral neuropathy and fibromyalgia (Parker et al, 2015). The analgesic effects of PGN have been associated with the modulation of neurotransmitter release or neuronal excitability due to alterations in Ca 21 currents Kavoussi, 2006).…”