“…Furthermore, there is evidence to suggest beneficial effects on a number of possible mechanisms of action implicated in the aetiology and pathophysiology of depression, including reducing stress ( Yao et al, 2021 ), inflammation ( Stier-Jarmer et al, 2021 ) and obesity ( Schalkwijk et al, 2018 ), improving wellbeing ( Martin et al, 2020 ; Pritchard et al, 2020 ; Pirchio et al, 2021 ) and improved sleep ( Shin et al, 2020 ). Coupled with the emerging literature that provides promising evidence suggesting a benefit for depression ( Hossain et al, 2020 ; Olafsdottir et al, 2020 ; Williams et al, 2020 ; Antonelli et al, 2021 ; Rosa et al, 2021 ; Stier-Jarmer et al, 2021 ), NBIs appear to be a viable strategy to pursue in mitigating the personal, social and societal burden of depression. We first outline the problem of depression and identify important issues that should inform the development of future interventions.…”