Trusted evidence. Informed decisions. Better health. Cochrane Database of Systematic Reviews Analysis 5.1. Comparison Comparison 5: benzodiazepines versus placebo, Outcome 1 Clinical Global Impressions -Improvement (CGI-I) or similar scale (acute phase

The efficacy and acceptability hierarchies generated by our study were robust against many sources of bias. The differences between drugs and placebo were small, with the only exception of phenelzine. Considering the small amount of available data, these results are probably not robust enough to suggest phenelzine as a drug of choice. However, findings from this review reinforce the idea that phenelzine should be prioritised in future trials in PTSD.

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