Comparative efficacy and acceptability of pharmacological treatments for post-traumatic stress disorder in adults: a network meta-analysis

Abstract

The efficacy and acceptability hierarchies generated by our study were robust against many sources of bias. The differences between drugs and placebo were small, with the only exception of phenelzine. Considering the small amount of available data, these results are probably not robust enough to suggest phenelzine as a drug of choice. However, findings from this review reinforce the idea that phenelzine should be prioritised in future trials in PTSD.

Comparative Efficacy and Acceptability of Pharmacological, Psychotherapeutic, and Combination Treatments in Adults With Posttraumatic Stress Disorder

“…This approach was chosen because previous network meta-analyses Research Original Investigation Pharmacological, Psychotherapeutic, and Combination Treatments in Adults With PTSD reported only nonsignificant differences between the included psychotherapeutic treatment approaches (ie, cognitive behavioral therapy, prolonged exposure, seeking safety, and eye movement desensitization and reprocessing), 14 as well as between the 3 selective serotonin reuptake inhibitors that were used as monotherapies in our included studies (ie, paroxetine hydrochloride, fluoxetine hydrochloride, and sertraline hydrochloride). 13 Nevertheless, the combined nodes may have contributed to heterogeneity and inconsistency. However, at the end of treatment, indicators of heterogeneity and inconsistency were small, and only in the long-term data did we find significant heterogeneity and inconsistency.…”

Veterans suffering from post-traumatic stress disorder – literature analyzing: symptoms, statistics and therapies

“…It is similar with one of the methods of psychotherapy -stress inoculation training (SIT) [15]. Antidepressants whose effect on PTSD did not differ from the placebo effect were primarily bupropion, citalopram, divalproex, mirtazapine, tiagabine and topiramata [14,15,17].…”

Mirtazapine and Depressions

“…Mirtazapine has been used to treat post-traumatic stress disorders (PTSD). However, mirtazapine is less effective than SSRIs as a drug class and venlafaxine for PTSD (Cipriani et al 2018b).…”