A systematic review of repetitive transcranial magnetic stimulation in aphasia rehabilitation: Leads for future studies

Arheix-Parras, Sophie; Barrios, Charline; Python, Grégoire; Cogné, Michel; Sibon, Igor; Engelhardt, Mélanie; Dehail, Patrick; Cassoudesalle, Hélène; Moucheboeuf, Geoffroy; Glize, Bertrand

doi:10.1016/j.neubiorev.2021.04.008

Cited by 24 publications

(9 citation statements)

References 92 publications

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“…These increased FC areas belong to the domain-general cognitive network, which implies that the domain-general cognitive network may be associated with recovery from aphasia ( Brownsett et al, 2014 ). Cognitive deficits in aphasic patients are difficult to measure because of challenges with verbal communication ( Arheix-Parras et al, 2021 ). The anterior paracingulate gyrus participates in speech processing through its connection to the prefrontal cortex, as confirmed by a previous fMRI study using word generation tasks ( Crosson et al, 1999 ).…”

Section: Discussionmentioning

confidence: 99%

Continuous theta burst stimulation-induced suppression of the right fronto-thalamic-cerebellar circuit accompanies improvement in language performance in poststroke aphasia: A resting-state fMRI study

Zheng

et al. 2023

Front. Aging Neurosci.

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BackgroundContinuous theta burst stimulation (cTBS) is a specific paradigm of repetitive transcranial magnetic stimulation (rTMS) with an inhibitory effect on cortical excitability for up to 60 min after less than 1 min of stimulation. The right posterior superior temporal gyrus (pSTG), homotopic to Wernicke’s area in the left hemisphere, may be a potential stimulation target based on its critical role in semantic processing. The objective of this study was to explore whether cTBS over the right pSTG can promote language improvements in aphasic patients and the underlying mechanism.MethodsA total of 34 subjects with aphasia were randomly assigned to undergo 15 sessions of either 40-s inhibitory cTBS over the right pSTG (the cTBS group) or sham stimulation (the sham group), followed by 30 min of speech and language therapy. Subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI), and the aphasia quotient (AQ) of the Chinese version of the Western Aphasia Battery (WAB) was calculated before and after the intervention. This randomized controlled trial was registered in the Chinese Clinical Trial Registry (No. ChiCTR210052962).ResultsAfter treatment, the language performance of the cTBS group was higher than that of the sham group in terms of the WAB-AQ score (p = 0.010) and the WAB scores for auditory comprehension (p = 0.022) and repetition (p = 0.035). The fractional amplitude of low-frequency fluctuations (fALFF) was significantly decreased in the pars triangularis of the inferior frontal gyrus (IFG), right middle frontal gyrus, right thalamus, and left cerebellar crus I. Clusters in the left orbitofrontal cortex exhibited increased fALFF. The change in WAB comprehension scores were significantly correlated with the change in the fALFF of the right IFG pars triangularis in both groups. Greatly increased functional connectivity was observed between the right pars triangularis and left paracingulate gyrus and between the right pSTG and right angular gyrus and the posterior cingulate gyrus with pre-and post-treatment between the two groups.ConclusionOur findings indicate that cTBS of the right pSTG may improve language production by suppressing intrinsic activity of the right fronto-thalamic-cerebellar circuit and enhancing the involvement of the right temporoparietal region.

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Section: Discussionmentioning

confidence: 99%

Continuous theta burst stimulation-induced suppression of the right fronto-thalamic-cerebellar circuit accompanies improvement in language performance in poststroke aphasia: A resting-state fMRI study

Zheng

et al. 2023

Front. Aging Neurosci.

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“…Studies have confirmed that there are many nutritional factors in the brain to promote the recovery and improvement of brain function in patients. After rTMS treatment, it may promote the release of some nutritional factors in the brain and promote the repair or improvement of damaged brain function ( Arheix-Parras et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…A large number of research results affirm its efficacy in the treatment of aphasia ( Rossetti et al, 2019 ), but the specific mechanism of action is still unclear. Some scholars use the method of functional magnetic resonance to explore the specific mechanism of the rTMS by the specific activated/inhibited brain regions, but the conclusions are very different ( Szaflarski et al, 2018 ; Arheix-Parras et al, 2021 ; Fahmy and Elshebawy, 2021 ; Neri et al, 2021 ). In addition, studies have also found that: after rTMS treatment, the levels of brain-derived neurotrophic factor in peripheral blood of patients with depression was higher than before, which may be one of the mechanisms of rTMS ( Zhao et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Study on Low-Frequency Repetitive Transcranial Magnetic Stimulation Improves Speech Function and Mechanism in Patients With Non-fluent Aphasia After Stroke

Bai

Jiang

Huan

et al. 2022

Front. Aging Neurosci.

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ObjectiveTo explore the therapeutic effect and mechanism of low-frequency repetitive transcranial magnetic stimulation on the speech function of patients with non-fluent aphasia after stroke.MethodsAccording to the inclusion and exclusion criteria, 60 patients with post-stroke non-fluent aphasia were included and randomly divided into treatment group (rTMS group) and sham stimulation group (S-rTMS group). Patients in rTMS group were given low-frequency rTMS + ST training. Patients in the S-rTMS group were given sham low-frequency rTMS + ST training. Once a day, 5 days a week, for a total of 4 weeks. The Western Aphasia Battery and the short-form Token test were used to evaluate the language function of the patients in the two groups before and after treatment. Part of the enrolled patients were subjected to functional magnetic resonance imaging examination, and the morning fasting venous blood of the enrolled patients was drawn before and after treatment to determine the content of BDNF and TNF-α.ResultsIn the comparison before and after treatment within the group, all dimensions of the WAB scale of the patients in the rTMS group increased significantly. Only two dimensions of the WAB scale of the patients in the S-rTMS group improved significantly after treatment. The results of the short-form Token test showed that patients in the rTMS group improved significantly before and after treatment. The resting state functional magnetic resonance imaging of the two groups of patients before and after treatment showed: the activation of multiple brain regions in the left hemisphere of the rTMS group increased compared with the control group. The serum BDNF content of the patients in the rTMS group was significantly higher than that of the patients in the S-rTMS group after treatment.ConclusionLow-frequency rTMS combined with conventional speech training can significantly improve the speech function of patients with non-fluent aphasia after stroke.

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“…Since late 1990s, applications of TMS on neurological rehabilitation and treatment of different neurological diseases have been the focus of researches. TMS on motor rehabilitation and dysphasia is gaining more and more support from evidences in literature [7][8][9][10]. With advancement in technology, introduction of navigated TMS provides more precise application of TMS in mapping and treatment.…”

Section: Historymentioning

confidence: 99%

Transcranial Magnetic Stimulation, Connectome and Its Clinical Applications

Yuen¹

2023

Advances in Electroencephalography and Brain Connectome

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Transcranial magnetic stimulation is an non-invasive method of neuromodulation. It uses magnetic field to induce generation of current for cortical stimulation. It can modulate the altered equilibrium in cortical excitability by magnetic field. Though it is famous for its application in treating psychiatric diseases, it has many other applications. Since its introduction in 1985, it has been used to check the integrity of motor pathway. With more understanding of the technique, it has been started to be used to check the integrity of other brain connections like speech and vision. Due to its ability of neuromodulation, it has also been used in cortical mapping in neurosurgery and neurological function rehabilitation.

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A systematic review of repetitive transcranial magnetic stimulation in aphasia rehabilitation: Leads for future studies

Cited by 24 publications

References 92 publications

Continuous theta burst stimulation-induced suppression of the right fronto-thalamic-cerebellar circuit accompanies improvement in language performance in poststroke aphasia: A resting-state fMRI study

Continuous theta burst stimulation-induced suppression of the right fronto-thalamic-cerebellar circuit accompanies improvement in language performance in poststroke aphasia: A resting-state fMRI study

Study on Low-Frequency Repetitive Transcranial Magnetic Stimulation Improves Speech Function and Mechanism in Patients With Non-fluent Aphasia After Stroke

Transcranial Magnetic Stimulation, Connectome and Its Clinical Applications

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