Objective: To assess the extent, pattern and determinants of non-prescription medicine use in an urban area of eastern India. Methods: A descriptive cross-sectional survey with total 392 subjects was carried out for 3 months by a structured questionnaire to assess the extent, pattern and determinants of non-prescription medicine use amongst the patients at a community retail medicine shop and a pharmacy running in Public-Private Partnership (PPP) model in a government hospital. Results: Our study found that 61.4% of the consumers indulged in the practice of self-medication. The commonest reason for self medication was a prevailing tendency in the community followed by cost-saving and convenience. The most commonly used medicines were antacids (43.4%) followed by analgesics-antipyretics (42.6%). It was found that only 12.5% completed an ongoing course of antibiotics. Consumption of ORS was commoner in diarrhoea than vomiting and only a few (13%) of the patients dissolved the ORS powder as directed. Only 9.7% of the subjects thought non-prescription medicine use is safe. Regarding the various types of medicine preparations used by them from the two types of pharmacy, a significant difference was noted only for eye drops (p = 0.003). This result might have been obtained due to prevailing ocular infections in the selected study population and underreporting at the Ophthalmology OPD of the nearest hospital. Conclusion: The current study has documented the extent of, factors associated with, and the pattern of non-prescription medicine use resulting in a surge of self-medication practice in urban area.Key words: Non-prescription medicine use, Self-medication, PPP model, Retail pharmacy, Survey. Key message: Given the increasing emphasis on self-care and empowering the public to manage their health with non-prescription medicines, the findings highlight the need for improved pharmacovigilance of these medicines to maximize benefits with minimal risk. Healthcare providers need to be aware of the potential for misuse, abuse and dependence, particularly in patients with long-term illness. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.