A systematic review of social functioning outcome measures in schizophrenia with a focus on suitability for intervention research

Long, Maria; Stansfeld, Jacki; Davies, Nathan; Crellin, Nadia

doi:10.1016/j.schres.2022.02.011

Cited by 16 publications

(7 citation statements)

References 99 publications

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“…Impairments of both social functioning (i.e. the ability to fulfil expected roles at work, social activities, and social relations with partners and family) (Long, Stansfeld, Davies, Crellin, & Moncrieff, 2022 ) and social cognition (i.e. the ability to decode the intentions and behaviours of others) (Green, 2016 ) are core features of PD and are thought to underlie severe functional disabilities (de Winter et al, 2021 ; Vita et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

et al. 2023

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Childhood maltreatment (CM) has been related to social functioning and social cognition impairment in people with psychotic disorders (PD); however, evidence across different CM subtypes and social domains remains less clear. We conducted a systematic review and meta-analysis to quantify associations between CM, overall and its different subtypes (physical/emotional/sexual abuse, physical/emotional neglect), and domains of social functioning and social cognition in adults with PD. We also examined moderators and mediators of these associations. A PRISMA-compliant systematic search was performed on 24 November 2022 (PROSPERO CRD42020175244). Fifty-three studies (N = 13 635 individuals with PD) were included in qualitative synthesis, of which 51 studies (N = 13 260) with 125 effects sizes were pooled in meta-analyses. We found that CM was negatively associated with global social functioning and interpersonal relations, and positively associated with aggressive behaviour, but unrelated to independent living or occupational functioning. There was no meta-analytic evidence of associations between CM and social cognition. Meta-regression analyses did not identify any consistent moderation pattern. Narrative synthesis identified sex and timing of CM as potential moderators, and depressive symptoms and maladaptive personality traits as possible mediators between CM and social outcomes. Associations were of small magnitude and limited number of studies assessing CM subtypes and social cognition are available. Nevertheless, adults with PD are at risk of social functioning problems after CM exposure, an effect observed across multiple CM subtypes, social domains, diagnoses and illness stages. Maltreated adults with PD may thus benefit from trauma-related and psychosocial interventions targeting social relationships and functioning.

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Section: Introductionmentioning

confidence: 99%

Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

et al. 2023

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“…It has been found that there is a positive link between the Big Five personality dimensions and sexual function, risky sexual behavior, sexual disorders, sexual satisfaction, emotional experiences in sex, attitude toward sex, and sexual unfaithfulness (Kurpisz et al, 2016). Lower levels of sexual performance and physical and emotional satisfaction are shown in schizophrenia patients (Long et al, 2022;Ludwig et al, 2022). Research on finding the association between affecting SNPs on the development of pathobiology of psychiatric disorders such as schizophrenia, depression, and bipolar disorder and formation and maintenance of couple romantic relationships could be helpful to pave the way to reveal the role of these variants in the sexual and emotional life of the population.…”

Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review

et al. 2023

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Introduction: Couples’ relationships defined by a complex interaction between the two partners and their intrapersonal traits. Romantic; relationships and love are associated with marital satisfaction and stability, as well as couples’ happiness and health. Personality traits influence romantic relationships and, personality influenced by genetical and non-genetically factors. The roles of non-genetically factors such as socioeconomic position and external appearance have revealed in determining the quality of romantic relationships.Methods: We; performed a scoping systematic review to assess the association between genetics and epigenetic factors and romantic relationship. Relevant articles were identified by PubMed, EMBASE, Web of Science, Scopus, and the APA PsycInfo searching between inception and 4 June 2022.Results: Different studies evaluated the associated polymorphisms in 15 different genes or chromosomal regions. In the first step; we classified them into four groups: (1) Oxytocin-related signaling pathway (OXTR, CD38, and AVPR1A); (2) Serotonin-related signaling pathway (SLC6A4, HTR1A, and HTR2A); (3) Dopamine and catecholamine-related signaling pathway (DRD1, DRD2, DRD4, ANKK1, and COMT); and (4) other genes (HLA, GABRA2, OPRM1, and Y-DNA haplogroup D-M55). Then, we evaluated and extracted significant polymorphisms that affect couple adjustment and romantic relationships.Discussion: Overall, the findings suggest that genetic and epigenetics variants play a key role in marital adjustment and romantic relationships over time.

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“…We included studies that addressed social functioning (SF) through questionnaire assessment or observer ratings of relationship functioning (e.g., number of close friends, psychosexual relationships); social behaviour in the milieu through observed behaviours in a specific social context (e.g., social behaviour on the ward); social problem solving , (e.g., ability to generate solutions in social situations); and social skills ( SS), (e.g., interaction abilities including conversation skills). Typically, social functioning and social behaviour in the milieu are based on ratings of real-world social behaviour, whereas social problem solving, and social skill are measures of social functional capacity that rely on task-based performance [ 6 , 42 ].…”

Section: Methodsmentioning

confidence: 99%

The social cognitive and neural mechanisms that underlie social functioning in individuals with schizophrenia – a review

Lemmers-Jansen,

Velthorst,

Fett

2023

Transl Psychiatry

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In many individuals with a diagnosis of schizophrenia social functioning is impaired across the lifespan. Social cognition has emerged as one of the possible factors that may contribute to these challenges. Neuroimaging research can give further insights into the underlying mechanisms of social (cognitive) difficulties. This review summarises the evidence on the associations between social cognition in the domains of theory of mind and emotion perception and processing, and individuals’ social functioning and social skills, as well as associated neural mechanisms. Eighteen behavioural studies were conducted since the last major review and meta-analysis in the field (inclusion between 7/2017 and 1/2022). No major review has investigated the link between the neural mechanisms of social cognition and their association with social functioning in schizophrenia. Fourteen relevant studies were included (from 1/2000 to 1/2022). The findings of the behavioural studies showed that associations with social outcomes were slightly stronger for theory of mind than for emotion perception and processing. Moreover, performance in both social cognitive domains was more strongly associated with performance on social skill measures than questionnaire-based assessment of social functioning in the community. Studies on the underlying neural substrate of these associations presented mixed findings. In general, higher activation in various regions of the social brain was associated with better social functioning. The available evidence suggests some shared regions that might underlie the social cognition-social outcome link between different domains. However, due to the heterogeneity in approaches and findings, the current knowledge base will need to be expanded before firm conclusions can be drawn.

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A systematic review of social functioning outcome measures in schizophrenia with a focus on suitability for intervention research

Cited by 16 publications

References 99 publications

Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

Genetic and epigenetic effects on couple adjustment in context of romantic relationship: A scoping systematic review

The social cognitive and neural mechanisms that underlie social functioning in individuals with schizophrenia – a review

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