A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

Abstract

Background: Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers.Methods: Studies were identified through systematic searches of Science Direct, PubMed, and Scopus as well as eligibility checks according to predefined selection criteria.Results: Eighty-seven studies were included in this systematic review. There was strong evidence for the association between treatment with naringin alone, or combined with other drugs and antitumor activity. Additionally, studies showed that naringin-metal complexes have greater anticancer effects compared to free naringin. It has been demonstrated that naringin employs multitargeted mechanisms to hamper cancer initiation, promotion, and progression through modulation of several dysregulated signaling cascades implicated in cell proliferation, autophagy, apoptosis, inflammation, angiogenesis, metastasis, and invasion.Conclusion: The results of our work show that naringin is a promising candidate for cancer prevention and treatment, and might offer substantial support for the clinical application of this phytocompound in the future. Nevertheless, further preclinical and clinical studies as well as drug delivery approaches are needed for designing novel formulations of naringin to realize the full potential of this flavonoid in cancer prevention and intervention.

Protective, Antioxidant and Antiproliferative Activity of Grapefruit IntegroPectin on SH-SY5Y Cells

“…Due to its anti-cancer, anti-apoptotic, anti-atherogenic, anti-inflammatory and antioxidant properties, naringin, adsorbed at the grapefruit IntegroPectin surface at a nearly 74 mg/g load [20], is currently intensively researched in light of utilization for cancer prevention and treatment [36]. One of the main limitations to its use as a therapeutic agent is the poor solubility in water (0.5 g/L [37]), which leads to poor pharmacokinetics [36]. It is likely that its dispersion on the highly soluble fibers of grapefruit IntegroPectin obtained upon freeze drying enhances its bioavailability.…”

Potential Mechanisms of Plant-Derived Natural Products in the Treatment of Cervical Cancer

“…Naringin, a flavonoid glycoside, can be isolated from citrus fruits, such as orange, tangerine, lemon and lime, and has several pharmacological activities [42]. Naringin can significantly reduce cancer cell viability and proliferation without toxicity to normal tissue cells [43]. The IC 50 values of naringin for HeLa, SiHa and C33A cells after 24-h treatment were 793, 764 and 745 µmol/L, respectively, and showed a dose-dependent relationship.…”

Neuroprotective, antioxidant and antiproliferative activity of grapefruit IntegroPectin on SH-SY5Y cells

“…For comparison, the highest yield values reported for naringin extracted from fresh grapefruit albedo is 10.5 mg/g [34]. Due to its anti-cancer, anti-apoptotic, anti-atherogenic, anti-inflammatory and antioxidant properties, naringin is currently intensively researched in light of utilization for cancer prevention and treatment [35]. One of the main limitations to its use as therapeutic agent is the poor solubility in water (0.5 g/L [36]) which leads to poor pharmacokinetics [35].…”

“…Due to its anti-cancer, anti-apoptotic, anti-atherogenic, anti-inflammatory and antioxidant properties, naringin is currently intensively researched in light of utilization for cancer prevention and treatment [35]. One of the main limitations to its use as therapeutic agent is the poor solubility in water (0.5 g/L [36]) which leads to poor pharmacokinetics [35]. It is likely that its dispersion on the highly soluble fibers of grapefruit IntegroPectin obtained upon freeze drying enhances its bioavailability.…”