A Systematic Review of the Risk of Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome

Shahbaz, Mahrukh; Almatooq, Halah; Foucambert, Paul; Esbrand, Faith D; Zafar, Sana; Panthangi, Venkatesh; Kurupp, Adrienne R Cyril; Raju, Anjumol; Luthra, Gaurav; Khan, Safeera

doi:10.7759/cureus.29928

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…This association was further affirmed by Harsha et al, who identified a 38.3% prevalence rate of NAHSD among women with polycystic ovaries, linking it to elevated levels of cholesterol, insulin, and liver enzymes, with hyperandrogenism identified as a significant predictor (12)(13)(14)(15). Sarkar et al also reinforced the connection between PCOS and NAHSD, advocating for routine screening for hepatic steatosis in patients diagnosed with PCOS (16)(17)(18). In our cohort, 46.5% of the women with PCOS were diagnosed with hepatic steatosis, indicating a substantial overlap between these two conditions.…”

Section: Discussionmentioning

confidence: 91%

Sonographic Association between Hepatic Steatosis Disease and Polycystic Ovarian Syndrome in Swabi Women

Khan,

Zubair,

Rehman

et al. 2024

JHRR

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Background: Polycystic Ovarian Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age, with significant implications for their fertility and metabolic health. Non-Alcoholic Hepatic Steatosis Disease (NAHSD), or fatty liver disease, has been increasingly recognized as a comorbidity in women with PCOS, suggesting a possible interrelation between these conditions that warrants further investigation. Objective: This study aimed to explore the association between NAHSD and PCOS among women in the Swabi district of Khyber Pakhtunkhwa, Pakistan, with an emphasis on understanding the prevalence and sonographic characteristics of these conditions in the affected population. Methods: A cross-sectional study was conducted at the Department of Radiology, Mahaban Medical and Research Hospital, Swabi, KP, Pakistan. The study included 86 women with a history of irregular menstrual cycles or amenorrhea. Sonographic examinations were performed using a Toshiba prime ultrasound machine with convex (3.0—5.0 MHz) and linear (7.0—14.0 MHz) transducers. Clinical and sonographic data pertaining to PCOS and NAHSD were collected, including ovarian volume and liver echogenicity grading. Statistical analysis was conducted using SPSS version 25. Results: The mean age of participants was 27.5 ± 4.8 years. The mean ovarian volumes were 11.52 ml (right ovary) and 10.80 ml (left ovary). The prevalence of NAHSD in our study cohort was 46.5%. Furthermore, hirsutism was observed in 22.1% of the patients. A significant association between the presence of NAHSD and PCOS was identified, with higher rates of hepatic steatosis observed among the PCOS patients compared to those without PCOS. Conclusion: The findings from this study underscore a significant association between NAHSD and PCOS among women in the Swabi district, suggesting that women with PCOS are at an increased risk of developing fatty liver disease. This association highlights the need for comprehensive screening and management strategies to address these comorbid conditions effectively.

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Section: Discussionmentioning

confidence: 91%

Sonographic Association between Hepatic Steatosis Disease and Polycystic Ovarian Syndrome in Swabi Women

Khan,

Zubair,

Rehman

et al. 2024

JHRR

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“…В исследованиях, в которых использовался многофакторный анализ, было отмечено, что сывороточные андрогены являются независимыми предикторами развития НАЖБП у этой категории пациенток [43]. Несмотря на значимость таких факторов риска, как ожирение и инсулинорезистентность, в развитии НАЖБП гиперандрогения, по-видимому, является наиболее существенным фактором у пациенток с СПКЯ [44]. Согласно метаанализу [45] у пациенток в пременопаузе с СПКЯ риск развития НАЖБП повышается в 2,5 раза.…”

Section: влияние женских половых гормонов на риск развития и прогресс...unclassified

Non-alcoholic fatty liver disease and women's health

Livzan¹,

Syrovenko²,

Кролевец³

2023

Russian Medical Inquiry

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This article is aimed to summarize data on the incidence and patterns of the non-alcoholic fatty liver disease (NAFLD) course among women of different age. The prevalence of NAFLD is growing worldwide. In general, the incidence of this liver disease in men is higher than in women. However, a detailed examination of various age groups revealed that in women of reproductive age, the NAFLD incidence was lower than in men; at the same time, after menopause, the disease incidence in women became equal to the incidence in men, even exceeded it according to some data. Ongoing epidemiological, clinical and experimental studies indicate a higher risk of NAFLD and liver fibrosis in women with postmenopause versus woman with premenopause, as well as that older women with NAFLD have a higher mortality rate than men. One of the key roles in metabolic changes that contribute, in particular, to the NAFLD development is assigned to estrogens. The relevance of the NAFLD detection and treatment in women is due to a significantly higher prevalence of age-adjusted cardiovascular diseases, 5-year mortality from all causes and 5-year cardiovascular mortality versus women without NAFLD. KEYWORDS: non-alcoholic fatty liver disease, fibrosis, steatosis, menopause, premenopause, pregnancy, estrogens, ursodeoxycholic acid. FOR CITATION: Livzan M.A., Syrovenko M.I., Krolevets T.S. Non-alcoholic fatty liver disease and women's health. Russian Medical Inquiry. 2023;7(5):310–317 (in Russ.). DOI: 10.32364/2587-6821-2023-7-5-9.

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“…Although the association between NAFLD and PCOS has been widely studied in adults, liver manifestations in adolescents with PCOS are largely unaddressed in the current literature. There are only seven original studies examining hepatic steatosis exclusively in adolescent patients [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Hepatic fibrosis has been assessed only in one study of PCOS patients, which included an adolescent sample [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Burden of Non-Alcoholic Fatty Liver Disease in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study

Giannouli

Efthymiou

Konidari

et al. 2023

JCM

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The aim of this case–control study was to assess the burden of non-alcoholic fatty liver disease (NAFLD) in adolescents with polycystic ovary syndrome (PCOS) and its associations with insulin resistance, hyperandrogenism, and other metabolic characteristics of the syndrome. A total of 87 Caucasian adolescent girls (47 with PCOS and 40 controls), aged 12.3–20.4 years, underwent blood sampling for glucose metabolism, hormonal and lipid profile, gynecological and liver ultrasound, and liver elastography. Indices of insulin resistance, liver steatosis, and liver fibrosis were calculated. NAFLD diagnosed by ultrasound was more prevalent in adolescents with PCOS than controls (22.7% vs. 6.1%, p = 0.046), and was also verified by liver steatosis indices. The latter was not apparent for hepatic fibrosis, as assessed by Fibroscan® and calculated indices. The homeostatic model assessment for insulin resistance (HOMA-IR) was found to predict NAFLD diagnosis by the liver fat score (LFS) index (β = 0.709, p = 0.002). Adolescents with PCOS and high free androgen index (FAI) presented worse NAFLD than those adolescents with PCOS and lower FAI. In addition, adolescents with PCOS and concurrent NAFLD had worse insulin sensitivity indices (HOMA-IR, QUICKI, and glucose to insulin ratio) than adolescents with PCOS alone. Adolescent insulin resistance could be considered a confounder of the association between PCOS and NAFLD.

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A Systematic Review of the Risk of Non-alcoholic Fatty Liver Disease in Women With Polycystic Ovary Syndrome

Cited by 6 publications

References 25 publications

Sonographic Association between Hepatic Steatosis Disease and Polycystic Ovarian Syndrome in Swabi Women

Sonographic Association between Hepatic Steatosis Disease and Polycystic Ovarian Syndrome in Swabi Women

Non-alcoholic fatty liver disease and women's health

The Burden of Non-Alcoholic Fatty Liver Disease in Adolescents with Polycystic Ovary Syndrome: A Case–Control Study

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