A Systematic Review of the Factors Affecting Accuracy of SUV Measurements

Adams, Michael C. C.; Turkington, T.G.; Wilson, Joshua M.; Wong, Terence Z.

doi:10.2214/ajr.10.4923

Cited by 522 publications

(407 citation statements)

References 40 publications

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“…Furthermore, a number of biological and technological factors influence the measurement of SUV max (21). Therefore, the exploration of other metabolic parameters is required.…”

Section: Discussionmentioning

confidence: 99%

18F-fluorodeoxyglucose positron emission computed tomography for monitoring tumor response in esophageal carcinoma treated with concurrent chemoradiotherapy

Zhang¹,

Wang

et al. 2017

Oncol Lett

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Abstract. The aim of the present study was to explore the value of 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) in monitoring the early tumor response of esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). A total of 48 patients with pathologically proven ESCC were retrospectively analyzed. All patients underwent two serial 18 F-FDG PET scans at baseline (pre-CRT) and 40 Gy/4 weeks of starting radiation therapy (inter-CRT). All patients received intensity-modulated radiotherapy (with a total radiation dose of 59.6 Gy) concurrently with cisplatin-based chemotherapy. The maximum standardized uptake value (SUV max ) and metabolic tumor volume (MTV) were measured using 18 F-FDG PET. The percentage changes (Δ) in SUV max and MTV between two serial scans were calculated and were revealed to be associated with the objective tumor response (oTR), according to the Response Evaluation Criteria in Solid Tumors 1.1. Among the 48 patients, 20.8% achieved a complete response, 68.8% exhibited a partial response and the oTR rate was 89.6%. On the pre-CRT PET scans, the mean SUV max and MTV were 14.1±5.8 and 58.2±25.4 cm . Univariate analysis revealed that ΔSUV max and ΔMTV were significantly associated with oTR (P= 0.010 and P= 0.001, respectively). ΔMTV was used as a predictor and a cut-off value of 54% discriminated responders from non-responders with a sensitivity of 69.8% and a specificity of 100% (P=0.001). The area under the receiver operating characteristic curve was 0.837 (95% confidence interval, 0.702-0.928). The results of the present study indicated that interim 18 F-FDG PET scans may provide early prognostic value for determining oTR in patients with ESCC undergoing treatment with CRT.

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“…Furthermore, a number of biological and technological factors influence the measurement of SUV max (21). Therefore, the exploration of other metabolic parameters is required.…”

Section: Discussionmentioning

confidence: 99%

18F-fluorodeoxyglucose positron emission computed tomography for monitoring tumor response in esophageal carcinoma treated with concurrent chemoradiotherapy

Zhang¹,

Wang

et al. 2017

Oncol Lett

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“…However, we noted that in Case 2, biopsied to be benign lupus lymphadenitis, the SUVmax was 13.2. Importantly, PET scanner and reconstruction methods are factors that intimately affect SUV measurements and stringent quality control measures are necessary when comparing studies [11].…”

Section: Discussionmentioning

confidence: 99%

Hypermetabolic Lymphadenopathy on PET CT in Systemic Lupus Erythematosus: A CaseReport

Timlin¹

2017

JRAD

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Background: New onset and active Systemic Lupus Erythematosus (SLE) may be infrequently associated with diffuse lymphadenopathy. This is often worrisome for malignancy in which F18/FDG PET scanning is typically obtained as part of a neoplastic workup. Results are often difficult to interpret and resemble lymphoma in many instances. There is sparse literature describing systematic differences in inflammation versus neoplasm pertaining to SLE in this context.

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“…The SUV max cutoff value in our study was thus lower than previously reported. The reason for this descrepancy may be that a large number of factors affect SUV measurements; these factors principally consist of biological factors such as body size, blood glucose levels, and patient breathing, as well as technological factors including interscanner variability, image reconstruction parameters, injected radioactivity, and the use of CT contrast material (13). Our study has some limitations: 1) we enrolled a small number of patients from a single center and performed retrospective analysis, which could lead to selection bias.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Diffusion-Weighted MRI and FDG PET/CT for Detecting the Local Recurrence of Head and Neck Squamous Cell Carcinoma

Öz¹,

Şerifoğlu²,

Salihoğlu³

et al. 2016

Istanbul Med J

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IntroductionFor patients with head and neck squamous cell carcinoma (HNSCC), multidisciplinary treatment involving surgery, radiotherapy, and/or chemotherapy improves survival and quality of life (1, 2). Despite aggressive combined management, locoregional recurrence is observed in approximately 40% of patients (3). Physical examination after treatment can be compromised by post-treatment changes, as surgical intervention can change the normal anatomy and radiotherapy can cause edema, inflammation, fibrosis, and necrosis (4). Particularly in the early stages of treatment, posttreatment follow-up imaging is also a challenge. Differentiation of post-treatment changes from a recurrence of HNSCC is generally not possible on computed tomography (CT) or magnetic resonance imaging (MRI); recurrent tumors and post-treatment changes may show similar appearances on routine MRI. After contrast administration, mass-like enhancement of post-treatment changes may mimic recurrence (1). Conversely, some recurrent tumors do not show enhancements, and thus, they cannot be distinguished from post-treatment changes (5).Diffusion-weighted MRI (DW-MRI) is sensitive to the randomized (Brownian) motion of water molecules. This imaging technique uses two opposite gradients of similar strength along a particular diffusion direction. The first gradient stimulates dephasing, and the second gradient will completely rephase all stationary molecules. Consequently, the movement of protons in living tissues results in incomplete rephrasing and is then converted into a decrease in the signal intensity on the resulting image (6, 7). The apparent diffusion coefficient ( Bulgular: Nüks saptanan hastalarda ADC ortalama değerleri saptanmayan hastalarla karşılaştırıldığında istatistiksel olarak anlamlı derecede düşük bulunmuştur (0,773'e karşı 1,588 x10-3/mm 2 sırasıyla, p<0,001). Nüks saptanan hastalarda SUV max değerleri saptanmaya hastalara göre istatistiksel olarak anlamlı derecede yüksek bulundu (15,642' karşı 4,508 sırasıyla; p<0,001). Nüks saptanan hastalarda ADC ortalama ve SUV max değerleri arasında anlamlı bir korelasyon izlenmedi (p=0,278, r=0,341). Nüks saptanmayan hastalarda ADC ortalama ve SUV max değerleri arasında negatif korelasyon saptandı (p=0,019, r=-0,691).Sonuç: PET/BT ve DAG-MRG baş-boyun SCC hastalarında tedavi sonrası nüksü saptamada etkin yöntemlerdir. Baş-Boyun SCC hastaları tedavi sonrası DAG-MRG ile takip edilebilir ve nüks şüphesi olan hastalarda PET-BT takip protokolüne eklenebilir.Anahtar Kelimeler: Baş ve boyun kanseri; difüzyon ağırlıklı görüntüleme, görünür difüzyon katsayısı, pozitron emisyon tomografisi/bilgisayarlı tomografi, standardize tutulum değeri Objective: To compare the efficacy between diffusion-weighted magnetic resonance imaging (DW-MRI) and positron emission tomography/computed tomography (PET/CT) in detecting the local recurrence of head and neck squamous cell carcinoma (HNSCC) following treatment in the same patient group. Methods: Twenty-three patients who had biopsy-proven HNSCC were enrolled. All ...

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A Systematic Review of the Factors Affecting Accuracy of SUV Measurements

Cited by 522 publications

References 40 publications

18F-fluorodeoxyglucose positron emission computed tomography for monitoring tumor response in esophageal carcinoma treated with concurrent chemoradiotherapy

18F-fluorodeoxyglucose positron emission computed tomography for monitoring tumor response in esophageal carcinoma treated with concurrent chemoradiotherapy

Hypermetabolic Lymphadenopathy on PET CT in Systemic Lupus Erythematosus: A CaseReport

Diagnostic Performance of Diffusion-Weighted MRI and FDG PET/CT for Detecting the Local Recurrence of Head and Neck Squamous Cell Carcinoma

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