2019
DOI: 10.1097/01.aoa.0000603664.92673.b5
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A Systematic Review of the Cost-effectiveness of Uterotonic Agents for the Prevention of Postpartum Hemorrhage

Abstract: Background: Several uterotonic options exist for prevention of postpartum hemorrhage (PPH); hence, cost-effectiveness is an important decision-making criterion affecting uterotonic choice.Objective: To conduct a systematic review of cost-effectiveness of uterotonics for PPH prevention to support a WHO guideline update.

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Cited by 10 publications
(13 citation statements)
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“…Two reviewers (JV and AW) independently assessed the eligibility of recovered citations using the Covidence platform, with disagreements resolved through discussion or consultation with a third reviewer 13 . A data extraction form was adapted from a 2019 systematic review of cost‐effectiveness of uterotonics by Lawrie et al, 14 which was adapted from NHS EED guidance 15 . For each eligible study, two reviewers independently extracted data relating to study design (aim, design, setting, year, sources of costs and effectiveness data, analytical perspective, time horizon) and relevant outcomes (costs of treatment options considered, main findings).…”
Section: Methodsmentioning
confidence: 99%
“…Two reviewers (JV and AW) independently assessed the eligibility of recovered citations using the Covidence platform, with disagreements resolved through discussion or consultation with a third reviewer 13 . A data extraction form was adapted from a 2019 systematic review of cost‐effectiveness of uterotonics by Lawrie et al, 14 which was adapted from NHS EED guidance 15 . For each eligible study, two reviewers independently extracted data relating to study design (aim, design, setting, year, sources of costs and effectiveness data, analytical perspective, time horizon) and relevant outcomes (costs of treatment options considered, main findings).…”
Section: Methodsmentioning
confidence: 99%
“…The updated review includes 196 trials involving 135 559 women 70. In parallel, WHO commissioned new systematic reviews on the views and experiences of women and healthcare providers, PPH prevention interventions and relevant uterotonic cost-effectiveness studies to inform relevant domains of evidence-to-decision frameworks for priority questions 71 72. WHO convened the PPH guideline panel for two virtual meetings (11-12 September and 3-4 October 2018) to review and update the relevant recommendations, which were published on 18 December 2018 40 73…”
Section: Step 5: Developing Recommendations With a ‘Living’ Guidelinementioning
confidence: 99%
“…2 Misoprostol has proven to be an effective uterotonic. 3 It is widely used for management of the third stage of labor. 4 It is also used for intractable postpartum hemorrhage when other medical interventions failed.…”
Section: Introductionmentioning
confidence: 99%