A systematic review on antioxidant and antiinflammatory activity of Sesame (Sesamum indicum L.) oil and further confirmation of antiinflammatory activity by chemical profiling and molecular docking

Abstract

Traditionally, sesame oil (SO) has been used as a popular food and medicine. The review aims to summarize the antioxidant and antiinflammatory effects of SO and its identified compounds as well as further fatty acid profiling and molecular docking study to correlate the interaction of its identified constituents with cyclooxygenase-2 (COX-2). For this, a literature study was made using Google Scholar, Pubmed, and SciFinder databases. Literature study demonstrated that SO has potential antioxidant and antiinflammatory effects in various test systems, including humans, animals, and cultured cells through various pathways such as inhibition of COX, nonenzymatic defense mechanism, inhibition of proinflammatory cytokines, NF-kB or mitogenactivated protein kinase signaling, and prostaglandin synthesis pathway. Fatty acid analysis of SO using gas chromatography identified known nine fatty acids. In silico study revealed that sesamin, sesaminol, sesamolin, stigmasterol, Δ5-avenasterol, and Δ7-avenasterol (−9.6 to −10.7 kcal/mol) were the most efficient ligand for interaction and binding with COX-2. The known fatty acid also showed binding efficiency with COX-2 to some extent (−6.0 to −8.4 kcal/mol). In summary, it is evident that SO may be one of promising traditional medicines that we could use in the prevention and management of diseases associated with oxidative stress and inflammation.

Effect of Zinc Deficiency on Blood Glucose, Lipid Profile, and Antioxidant Status in Streptozotocin Diabetic Rats and the Potential Role of Sesame Oil

“…Sesame as a traditional healthy food has a great nutritional value due to its high fatty acid content (oleic acid, linoleic acid, palmitic acid, stearic acid) and bioactive compounds including phytosterols, lignans (sesamin, sesamol, episesamin, sesamolin, sesaminol), and vitamin E [13]. It shows numerous biological properties such as antioxidant [14], anti-inflammatory [15], antihypertensive [16], and hypocholesterolemic [17]. Moreover, sesame has a protective effect in managing diseases associated to oxidative stress such as diabetes mellitus [18], obesity [19], chronic renal failure [20], and neurodegenerative diseases [21].…”

Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation

“…F. asafoetida is known to use for the treatment of respiratory problems, including bronchitis, asthma, and whooping coughs [ 39 ]. Additionally, these spice bioactives have exhibited several beneficial activities, including antifungal, antioxidant, hepatoprotective, anti-inflammatory, and have immune-boosting properties [ 16 , [38] , [39] , [40] , [41] , [42] ].…”

An Insight into Sesamolin: Physicochemical Properties, Pharmacological Activities, and Future Research Prospects

“…The health benefits of sesame seeds were largely contributed by its lignans content such as sesamin, sesamol, and sesamolin. Several recent reviews have presented the pharmacological activity of sesame oils in in vitro and in vivo experiments; some of them also prefer to focus on the pharmacological effect of sesame lignans compound like sesamol or sesamin [ 7 , 8 , 9 , 10 ]. Sesamolin, one of the major sesame lignan compounds, has been reported to possess antioxidant, neuroprotective, and anticancer activities.…”