A systematic review on the distribution of Mycobacterium bovis infection among wildlife in the Americas

Domingos, Susan Christina Braga; Júnior, Herzem R. Carioca; Lilenbaum, Walter; Rosa, Myrna Tielly Santa; Pereira, Cynthia Dias; Medeiros, Luciana S.

doi:10.1007/s11250-019-01954-7

Cited by 6 publications

(4 citation statements)

References 36 publications

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Section: Introductionmentioning

confidence: 99%

“…accounted for $20.9 billion of the United States Gross Domestic Product, with an additional $3.1 billion and $1.9 billion earned from federal and state tax revenues, respectively [21]. Importantly, cervids also serve as hosts for many pathogens originating in domestic animals, humans and wildlife reservoirs, including those that cause chronic wasting disease (CWD, [3]), bovine tuberculosis [22], brucellosis [23], and most recently, COVID-19 [24]. Not only do many of these diseases have substantial impacts on the health and persistence of cervid populations, but the relatively close evolutionary relationships between cervids and some domestic species (primarily Bovidae) suggests that the effects of outbreaks in these populations may have additional consequences via spillover or spillback to livestock (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Metagenomic sequencing sheds light on microbes putatively associated with pneumonia-related fatalities of white-tailed deer (Odocoileus virginianus)

Prentice,

Gilbertson,

Storm

et al. 2024

Microbial Genomics

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With emerging infectious disease outbreaks in human, domestic and wild animal populations on the rise, improvements in pathogen characterization and surveillance are paramount for the protection of human and animal health, as well as the conservation of ecologically and economically important wildlife. Genomics offers a range of suitable tools to meet these goals, with metagenomic sequencing facilitating the characterization of whole microbial communities associated with emerging and endemic disease outbreaks. Here, we use metagenomic sequencing in a case-control study to identify microbes in lung tissue associated with newly observed pneumonia-related fatalities in 34 white-tailed deer (Odocoileus virginianus) in Wisconsin, USA. We identified 20 bacterial species that occurred in more than a single individual. Of these, only Clostridium novyi was found to substantially differ (in number of detections) between case and control sample groups; however, this difference was not statistically significant. We also detected several bacterial species associated with pneumonia and/or other diseases in ruminants (Mycoplasma ovipneumoniae, Trueperella pyogenes, Pasteurella multocida, Anaplasma phagocytophilum, Fusobacterium necrophorum); however, these species did not substantially differ between case and control sample groups. On average, we detected a larger number of bacterial species in case samples than controls, supporting the potential role of polymicrobial infections in this system. Importantly, we did not detect DNA of viruses or fungi, suggesting that they are not significantly associated with pneumonia in this system. Together, these results highlight the utility of metagenomic sequencing for identifying disease-associated microbes. This preliminary list of microbes will help inform future research on pneumonia-associated fatalities of white-tailed deer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metagenomic sequencing sheds light on microbes putatively associated with pneumonia-related fatalities of white-tailed deer (Odocoileus virginianus)

Prentice,

Gilbertson,

Storm

et al. 2024

Microbial Genomics

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“…In the UK and Ireland, M. bovis in badgers complicates bTB control efforts and similarly in the US, New Zealand, and Spain where deer, possum, and wild boar, respectively, are also recognized M. bovis reservoirs (4,9). In the Americas, there are 15 wild species reported as infected with M. bovis (10). In South Africa, bTB is endemic in two major national parks, namely Kruger National and Hluhluwe-iMfolozi Parks (7).…”

Section: Introductionmentioning

confidence: 99%

“…For example, progress has been made in enhancing the detection of bTB infection in cattle by combining IGRAs with the simultaneous measurement of antigen-specific interleukin-1β (IL-1β) or IFN γ-induced protein 10 (IP-10) (29)(30)(31). A systematic review by Domingos et al (10) of M. bovis diagnostic methods in wildlife species also suggested the application of at least two tests to aid the detection of infection and potentially different disease stages.…”

Section: Introductionmentioning

confidence: 99%

Cell-Mediated Immunological Biomarkers and Their Diagnostic Application in Livestock and Wildlife Infected With Mycobacterium bovis

et al. 2021

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Mycobacterium bovis has the largest host range of the Mycobacterium tuberculosis complex and infects domestic animal species, wildlife, and humans. The presence of global wildlife maintenance hosts complicates bovine tuberculosis (bTB) control efforts and further threatens livestock and wildlife-related industries. Thus, it is imperative that early and accurate detection of M. bovis in all affected animal species is achieved. Further, an improved understanding of the complex species-specific host immune responses to M. bovis could enable the development of diagnostic tests that not only identify infected animals but distinguish between infection and active disease. The primary bTB screening standard worldwide remains the tuberculin skin test (TST) that presents several test performance and logistical limitations. Hence additional tests are used, most commonly an interferon-gamma (IFN-γ) release assay (IGRA) that, similar to the TST, measures a cell-mediated immune (CMI) response to M. bovis. There are various cytokines and chemokines, in addition to IFN-γ, involved in the CMI component of host adaptive immunity. Due to the dominance of CMI-based responses to mycobacterial infection, cytokine and chemokine biomarkers have become a focus for diagnostic tests in livestock and wildlife. Therefore, this review describes the current understanding of host immune responses to M. bovis as it pertains to the development of diagnostic tools using CMI-based biomarkers in both gene expression and protein release assays, and their limitations. Although the study of CMI biomarkers has advanced fundamental understanding of the complex host-M. bovis interplay and bTB progression, resulting in development of several promising diagnostic assays, most of this research remains limited to cattle. Considering differences in host susceptibility, transmission and immune responses, and the wide variety of M. bovis-affected animal species, knowledge gaps continue to pose some of the biggest challenges to the improvement of M. bovis and bTB diagnosis.

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A study of the incidence of bovine tuberculosis in the wild red deer herd of Exmoor

Collard¹

2023

Eur J Wildl Res

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A systematic review on the distribution of Mycobacterium bovis infection among wildlife in the Americas

Cited by 6 publications

References 36 publications

Metagenomic sequencing sheds light on microbes putatively associated with pneumonia-related fatalities of white-tailed deer (Odocoileus virginianus)

Metagenomic sequencing sheds light on microbes putatively associated with pneumonia-related fatalities of white-tailed deer (Odocoileus virginianus)

Cell-Mediated Immunological Biomarkers and Their Diagnostic Application in Livestock and Wildlife Infected With Mycobacterium bovis

A study of the incidence of bovine tuberculosis in the wild red deer herd of Exmoor

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